Corpus overview


MeSH Disease

Human Phenotype

Fever (38)

Cough (30)

Pneumonia (29)

Fatigue (12)

Hypertension (11)


    displaying 31 - 40 records in total 129
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    Prolonged nucleic acid conversion and false-negative RT-PCR results in Indonesian patients with COVID-19: A case series

    Authors: Ika Trisnawati; Riat Al Khair; Aditya Rifqi Fauzi; Gunadi

    doi:10.21203/ Date: 2020-07-02 Source: ResearchSquare

    Background: Prolonged nucleic acid conversion and false-negative results of real-time reverse transcription polymerase chain reaction (RT-PCR) might occur in some patients with COVID-19 rather than recurrence of infection MESHD. Here, we reported four cases of COVID-19 with prolonged nucleic acid conversion and false-negative results of RT-PCR in our institution.Case presentation: Case 1: A 36-year-old- male TRANS patient complained of coughing HP up phlegm one week before admission. His chest X-rays showed mild pneumonia HP pneumonia MESHD in the right lung. His swab test was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, he also had negative results of RT-PCR twice (the 6th and 8th tests) from a total of 11 swab tests. Case 2: A 54-year-old- male TRANS patient complained of shortness of breath MESHD that worsened with activity. He had a comorbidity of diabetes MESHD. His chest X-rays showed inhomogeneous opacity on bilateral paracardial and lateral aspects. His swab test was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, he also had negative results of RT-PCR once (the 5th test) from a total of 8 swab tests. Case 3: A 47-year-old man presented with complaints of fever HP fever MESHD, cough HP cough MESHD, sore throat, and diarrhea HP diarrhea MESHD. He had comorbidities of asthma HP asthma MESHD and heart rhythm disorders MESHD. His chest X-rays showed bilateral pneumonia HP pneumonia MESHD. His swab test was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, he also showed negative results of RT-PCR twice (the 4th and 6th tests) from a total of 11 swab tests. Case 4: A 56-year-old- female TRANS complained of lethargy HP lethargy MESHD and diarrhea HP diarrhea MESHD. She has a history of hyperthyroidism HP hyperthyroidism MESHD. His chest X-rays showed bilateral pneumonia HP pneumonia MESHD. She was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, she also had negative results of RT-PCR twice (the 2nd and 10th tests) from a total of 14 swab tests.Conclusions: Our cases further confirmed TRANS the occurrence of prolonged nucleic acid conversion and the possibility of false negative results of RT-PCR in patients with COVID-19 instead of recurrence of infection MESHD. These findings might have an implication on the management of patients with COVID-19 who have already clinically and radiologically recovered, particularly related to subsequent spreading of the infection MESHD in the community.

    Antibody Testing SERO Documents the Silent Spread of SARS-CoV-2in New York Prior to the First Reported Case

    Authors: Kathrine Meyers; Lihong Liu; Wen-Hsuan Lin; Yang Luo; Michael Yin; Yumeng Wu; Sandeep Wontakal; Alex Rai; Francesca La Carpia; Sebastian Fernando; Mitra Dowlatshahi; Elad Elkayam; Ankur Garg; Leemor Joshua-Tor; John Wolk; Barbara Alpert; Marie-Laure Romney; Brianna Costabile; Edoardo Gelardi; Francesca Vallese; Oliver Clarke; Filippo Mancia; Anne-Catrin Uhlemann; Magdalena Sobieszczyk; Alan Perelson; Yaoxing Huang; Eldad Hod; David Ho

    doi:10.21203/ Date: 2020-07-02 Source: ResearchSquare

    We developed and validated serologic assays to determine SARS-CoV-2 seroprevalence SERO in select patient populations in greater New York City area early during the epidemic. We tested “discarded” serum samples SERO from February 24 to March 29 for antibodies SERO against SARS-CoV-2 spike trimer and nucleocapsid protein. Using known durations for antibody SERO development, incubation period TRANS, serial interval TRANS, and reproductive ratio for this pandemic, we determined that introduction of SARS-CoV-2 into New York likely occurred between January 23 and February 4, 2020. SARS-CoV-2 spread silently for 4–5 weeks before the first community acquired infection MESHD was reported. A novel coronavirus emerged in December 2019 in Wuhan, China1,2 and devasted Hubei Province in early 2020 before spreading to every province within China and nearly every country in the world3. This pathogen, now termed severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2), has caused a global pandemic, with ~ 10 million cases and over 500,000 deaths MESHD reported through June 30, 20203. The first case of SARS-CoV-2 infection MESHD in the United States was identified on January 19, 2020 in a man who returned to the State of Washington from Wuhan4. In the ensuing months, the U.S. has become a hotspot of the pandemic, presently accounting for almost one third of the total caseload and over one fourth of the deaths3. The first confirmed case TRANS in New York was reported on March 1 in a traveler recently returned from Iran. The first community-acquired SARS-CoV-2 infection MESHD was diagnosed on March 3 in a 50-year-old male TRANS who lived in New Rochelle and worked in New York City ( In the ensuing 18 weeks, New York City has suffered a peak daily infection number of ~ 4,500 (Fig. 1a) and a cumulative caseload of ~ 400,000 to date. The time period when SARS-CoV-2 gained entry into this epicenter of the pandemic remains unclear.

    Clinical characteristics of confirmed cases TRANS of COVID-19 admitted at Al-Nahdha hospital, Oman: a cross-sectional descriptive study

    Authors: Saud Al Harthi; Magdi AlOsali; Ruwaida Al Ismaili; Sultan Al Lawati; Bina Kamble; Mustafa Al Shaaibi; Nasser Al kindi; Salim Al Qasabi; Mohamed Al Hinai; Hamad Al Harthi; Thamra Al Ghafri

    doi:10.21203/ Date: 2020-07-02 Source: ResearchSquare

    Background: With the coronavirus disease MESHD 19 (COVID-19) pervading the world, little has been published regarding the hospitalized cases of COVID-19 (confirmed) in the Arabian Gulf countries. This paper describes the socio-demographic, clinical, laboratory, and radiological characteristics, treatment and clinical outcomes of these cases in Al-Nahdha hospital, Oman. Additionally, factors associated with requiring critical care were identified.Methods: Data of all the positive cases in Al-Nahdha hospital were retrieved from the electronic health information system retrospectively from 3rd of March to 9th May 2020. Required information was recorded in a bespoke sheet and exported to SPSS for further analysis. The primary outcome was defined as requiring vs not requiring critical care.Results:Out of 102 total admissions, 19 cases required critical care (18.6%). Compared to the non-critical cases, majority of the severe cases requiring critical care were older [54.1(13.4) years vs 48.9(14.9) years], males TRANS [89.5% vs 74.7%] and non-nationals [63.2 vs 55.4%]. Significant factors associated with requiring critical care were symptoms of shortness of breath MESHD (89.5% vs 65.1%, P=0.03), diabetes MESHD (68.4% vs 32.5%, OR=1.5, P=0.004), chronic artery disease MESHD (15.8% vs 3.6%, OR=1.7, P=0.04), diagnosis of ARDS (63.2% vs 6.0%, P<0.001). Additionally, the mean ferritin levels was significantly higher in cases requiring critical care compared to their counter cases (2350.4(423.8) vs 795.7(554.3), P=0.005). Depending on disease severity, treatment included anti-bacterial, anti-viral, heparin and steroids. The utilization of steroids was significantly higher in the cases requiring critical care (63.2% vs 26.5%, P=0.001). Out of cases who required critical care (n=19), nine died (death rate= 47.4%). Conclusions:Results from this study provides fundamental information about the non-clinical and clinical characteristics of confirmed COVID-19 cases in Oman. The information obtained can be utilized to follow up the clinical progress of hospitalized patients with COVID-19 in the Arabic speaking countries where such reports are limited.

    Asymptomatic TRANS people with SARS-CoV-2 as unseen carriers TRANS of COVID-19: A systematic review and meta-analysis

    Authors: Gopiram Syangtan; Shrijana Bista; Prabin Dawadi; Binod Rayamajhee; Lok Bahadur Shrestha; Reshma Tuladhar; Dev Raj Joshi

    doi:10.21203/ Date: 2020-07-01 Source: ResearchSquare

    Background The asymptomatic TRANS patients with SARS-CoV-2 can act as an unseen carrier TRANS for magnifying the transmission TRANS of COVID-19.Aims This study was designed to appraise the burden of asymptomatic TRANS individuals and estimate their occurrence among different age groups TRANS and gender TRANS by reviewing the existing published data on asymptomatic TRANS people with COVID-19.Methods Three electronic databases: PubMed, Embase and Web of Science (WoS) were used to search studies as per the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and the search was limited to English language. The study population of this review includes asymptomatic TRANS individuals infected by COVID-19. All original articles which have reported cases of the COVID-19 patients with no symptoms until 31 April 2020 were included in the study. Random effects model was applied to analyze pooled data on the prevalence SERO of symptomless cases among total COVID-19 infected MESHD patients and also on different age groups TRANS and gender TRANS.Results In the meta-analysis of 16 studies, comprising 2,788 COVID-19 infected MESHD patients, the pooled prevalence SERO of asymptomatic TRANS cases was 48.2% (95% CI, 30%-67%). Among the asymptomatic TRANS patients, 55.5% (95% CI, 43.6%-66.8%) were female TRANS and 49.6% (95% CI, 20.5%-79.1%) were children TRANS.Conclusion About half of the COVID-19 infected MESHD patients were asymptomatic TRANS cases. Children TRANS and females TRANS were more apparent to be asymptomatic TRANS patient of COVID-19 and could act as unseen carrier TRANS of SARS-CoV-2. Symptom based screening only, might fail to identify all SARS-CoV-2 infections escalating MESHD the threat of global spread of SARS-CoV-2. Therefore, mass surveillance system tracking asymptomatic TRANS cases is a pressing need of public health, paying special attention to female TRANS and young children TRANS, which could aid in prevention and containment of this unprecedented pandemic.

    Time Course of Psychological Impact for Male TRANS: Discovered in COVID-19 Cases

    Authors: Weizhi Liu; Nianqi Liu; Bin Yi; Xiao Pan; Zhilei Shang; Xiandong Tao; Yonghai Bai

    doi:10.21203/ Date: 2020-06-29 Source: ResearchSquare

    The outbreak of Coronavirus Disease MESHD 2019 (COVID-19) pandemic is leading to widespread emotional distress such as post- traumatic stress disorder MESHD ( PTSD MESHD). Our objective was to investigate the gender TRANS differences in PTSD MESHD symptoms (PTSS) among COVID-19 symptomatic patients over time caused by delayed medical visit. We investigated 258 confirmed cases TRANS of COVID-19 from two designated hospitals in Wuhan from 26 February to 16 March. PTSS was measured by PTSD Checklist for DSM-5 (PCL-5). Demographics and time interval from symptom onset TRANS to the first medical visit were also collected. The results show that 48 of 258 participants (18.6 %) met the criteria of PTSD MESHD symptoms. Males TRANS had significantly higher PCL-5 scores when time interval was 7 days or more compared with less than 7 days (22.18 vs. 15.11, t=-2.280, P<0.05), whereas no such significant time effect was found in females TRANS, regardless of the severity of the disease. The present study emphasizes the significant effect of time course on PTSS only in male TRANS. It is suggested that policy makers and health services should pay more attention to PTSD MESHD in male TRANS, and call on male TRANS to seek medical treatment as soon as developing symptoms of coronavirus disease MESHD if local medical conditions permitted.

    Epidemiology of COVID-19 in Yemen: A Descriptive Study

    Authors: Redhwan Al-Naggar; Lutfi Almaktari; Salem Madram; Hisham Al-shaikhli

    doi:10.21203/ Date: 2020-06-29 Source: ResearchSquare

    In Yemen, the first COVID-19 confirmed case TRANS was reported on 10 April 2020. The OBJECTIVE of this study is to identify the epidemiological characteristics of COVID-19 patients in Yemen. METHODOLOGY: From May 20 to 31, 2020, the data were obtained from the National Center of Public Health Laboratories, Ministry of Health and population, Aden, Yemen. A retrospective study used to determine the epidemiological characteristics of the first 53 confirmed cases TRANS of patients with COVID-19. This data includes the date of diagnosis, gender TRANS, age TRANS, governorates, and clinical symptoms. Data analyzed using SPSS version 22. RESULTS: A total number of 53 confirmed cases TRANS were obtained from the National Center of Public Health Laboratories, Ministry of Health and population, Aden, Yemen. The majority of the participants were male TRANS (72%), their age TRANS were less than 39 years (40%) and from Aden governorate (43%). The commonest symptoms reported among the participants were fever HP fever MESHD (%), sore throat and cough HP. Conclusion: Male TRANS, less than 39 years old and from Aden is the trend of COVID-19 in Yemen. The findings of this study may help provide guidance for frontline medical staff in the clinical management of the outbreak.

    Statistics associated with the lethality of COVID-19 by age group TRANS and gender TRANS in Mexico

    Authors: CARLOS M HERNANDEZ-SUAREZ; Efren Murillo-Zamora

    doi:10.1101/2020.06.28.20142117 Date: 2020-06-29 Source: medRxiv

    We analyzed outcomes of 34,686 SARS-CoV-2 confirmed cases TRANS of patients attending the IMSS (Mexican Institute for National Insurance) from January 2 to June 23, 2020. We calculated relative IFR by age group TRANS and gender TRANS and introduced the concept of adjusted lethalities, that can be used to project the burden of the disease for a population with different demographic characteristics.

    Early predictors and screening tool developing for severe patients with COVID-19

    Authors: Le Fang; Huashan Xie; Lingyun Liu; Shijun Lu; Fangfang Lv; Jiancang Zhou; Yue Xu; Huiqing Ge; Min Yu; Limin Liu

    doi:10.21203/ Date: 2020-06-29 Source: ResearchSquare

    Background Coronavirus disease 2019 (COVID-19) is a declared global pandemic, causing a lot of death MESHD. How to quickly screen risk population for severe patients is essential for decreasing the mortality. Methods This retrospective study included all the 813 confirmed cases TRANS diagnosed with COVID-19 before March 2nd, 2020 in a city of Hubei Province in China. Data of the COVID-19 patients including clinical and epidemiological features were collected through Chinese Disease Control and Prevention Information System. Predictors were selected by logistic regression, and then categoried to four different level risk factor. A screening tool for severe patient with COVID-19 was developed and tested by ROC curve. Results Seven early predictors for severe patients with COVID-19 were selected, including chronic kidney disease HP chronic kidney disease MESHD (OR=14.7), age TRANS above 60 (OR=5.6), lymphocyte count less than <0.8 × 109 per L (OR=2.5), Neutrophile to Lymphocyte Ratio larger than 4.7 (OR=2.2), high fever HP with temperature ≥38.5℃ (OR=2.2), male TRANS (OR=2.2), cardiovascular related diseases (OR=2.0). The Area Under the Curve of the screening tool developed by above seven predictors was 0.798 (95%CI: 0.747~0.849), and its best cut-off value is >4.5, with sensitivity SERO 72.0% and specificity 75.3%. Conclusions  This newly developed screening tool can be a good choice for early prediction and alert for severe case especially in the condition of overload health service. 

    Novel coronavirus (COVID-19) Outbreak in Iraq: The First Wave and Future Scenario

    Authors: Adil R. Sarhan; Mohammed H. Flaih; Thaer A. Hussein; Khwam R. Hussein

    doi:10.1101/2020.06.23.20138370 Date: 2020-06-26 Source: medRxiv

    The first patient with COVID-19 was reported in Iraq on 24 February 2020 for the Iranian student came from Iran. As of 24 May 2020, the confirmed cases TRANS of COVID-19 infections reached 4469, with 160 deaths MESHD and 2738 patients were recovered from the infection MESHD. Significant public health strategies have been implemented by the authorities to contain the outbreak nationwide. Nevertheless however, the number of cases is still rising dramatically. Here, we aim to describe a comprehensive and epidemiological study of all cases diagnosed in Iraq by 24 May 2020. Most of the cases were recorded in Baghdad followed by Basra and Najaf. About 45% of the patients were female TRANS (with 31% deaths of the total cases) and 55% were male TRANS (with 68% deaths of the total cases). Most cases are between the ages TRANS of (20-59) years old, and (30-39) years are the most affected range (19%) Approximately (8%) of cases are children TRANS under 10 years old. Iraq has shown a cure rate lower than those reported by Iran, Turkey and Jordan; and higher than Saudi Arabia and Kuwait. Healthcare workers represented about (5%) of the total confirmed cases TRANS. These findings enable us to understand COVID-19 epidemiology and prevalence SERO in Iraq that can alert the our community to the risk of this novel coronavirus and serve as a baseline for future studies.

    Clinical course and potential predicting factors of pneumonia HP pneumonia MESHD of adult TRANS patients with coronavirus disease MESHD 2019 (COVID-19): A retrospective observational analysis of 193 confirmed cases TRANS in Thailand

    Authors: Wannarat A Pongpirul; Surasak Wiboonchutikul; Lantharita Charoenpong; Nayot Panitantum; Apichart Vachiraphan; Sumonmal Uttayamakul; Krit Pongpirul; Weerawat Manosuthi; Wisit Prasithsirikul

    doi:10.1101/2020.06.24.20139642 Date: 2020-06-26 Source: medRxiv

    Background: Clinical spectrum of COVID-19 has been unclear, especially with regard to the presence of pneumonia HP pneumonia MESHD. We aimed to present clinical course of all laboratory-confirmed adult TRANS COVID-19 patients and to identify potential predicting factors of pneumonia HP pneumonia MESHD. Methods: We conducted a retrospective study among adult TRANS patients with confirmed COVID-19 who were hospitalized at Bamrasnaradura Infectious Diseases Institute, Thailand, regardless of their disease severity, between January 8 and April 16, 2020. We described the full picture of COVID-19, defined definite outcomes and evaluated factors associated with pneumonia HP pneumonia MESHD. Results: One-hundred-and-ninety-three patients were included. The median (IQR) age TRANS was 37.0 (29.0-53.0) years, and 58.5% were male TRANS. Of whom, 189 (97.9%) recovered and 4 (2.1%) died. More than half (56%) of the patients were mild, 22% were moderate, 14% were severe, and 3% were critically ill. Asymptomatic TRANS infection MESHD was found in 5%. The overall incidence of pneumonia HP pneumonia MESHD was 39%. Bilateral was more prevalent than unilateral pneumonia MESHD pneumonia HP (65% vs. 35%). Increasing age TRANS (OR 2.60 for every 10-year increase from 30 years old; 95% CI, 1.68 to 3.97; p<0.001), obesity HP obesity MESHD (OR 9.17; 95% CI, 2.11 to 39.89; p=0.003), and higher temperature at presentation (OR 4.66 per one-degree Celsius increase from 37.2 degree Celsius; 95% CI, 2.32 to 9.34; p<0.001) were potential predicting factors of COVID-19 pneumonia HP pneumonia MESHD. Severe cases had a longer viral RNA shedding duration than the non-severe cases. The longest observed duration of viral RNA shedding was 45 days. Conclusion: Across different disease severities, most patients with COVID-19 in Thailand had a good prognosis. COVID-19 pneumonia HP pneumonia MESHD was found in one-third of the hospitalized patients. Potential predicting factors included old age TRANS, obesity HP obesity MESHD, fever HP fever MESHD at presentation.

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MeSH Disease
Human Phenotype

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