Corpus overview


MeSH Disease

Human Phenotype

Fever (36)

Cough (28)

Pneumonia (28)

Hypertension (11)

Fatigue (11)


    displaying 41 - 50 records in total 127
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    Authors: Antoni Sisó-Almirall; Belchin Kostov; Minerva Mas-Heredia; Sergi Vilanova-Rotllan; Ethel Sequeira-Aymar; Mireia Sans-Corrales; Elisenda Sant-Arderiu; Laia Cayuelas-Redondo; Angela Martínez-Pérez; Noemí García Plana; August Anguita-Guimet; Jaume Benavent-Àreu

    doi:10.1101/2020.06.18.20134510 Date: 2020-06-20 Source: medRxiv

    Background In addition to the lack of COVID-19 diagnostic tests for the whole Spanish population, the current strategy is to identify the disease early to limit contagion in the community. Aim To determine clinical factors of a poor prognosis in patients with COVID-19 infection MESHD. Design and Setting Descriptive, observational, retrospective study in three primary healthcare centres with an assigned population of 100,000. Method Examination of the medical records of patients with COVID-19 infections confirmed TRANS by polymerase chain reaction. Results We included 322 patients (mean age TRANS 56.7 years, 50% female TRANS, 115 (35.7%) aged TRANS [≥] 65 years). The best predictors of ICU admission or death MESHD were greater age TRANS, male TRANS sex (OR=2.99; 95%CI=1.55 to 6.01), fever HP fever MESHD (OR=2.18; 95%CI=1.06 to 4.80), dyspnoea MESHD (OR=2.22; 95%CI=1.14 to 4.24), low oxygen saturation (OR=2.94; 95%CI=1.34 to 6.42), auscultatory alterations (OR=2.21; 95%CI=1.00 to 5.29), heart disease MESHD (OR=4.37; 95%CI=1.68 to 11.13), autoimmune disease MESHD (OR=4.03; 95%CI=1.41 to 11.10), diabetes MESHD (OR=4.00; 95%CI=1.89 to 8.36), hypertension HP hypertension MESHD (OR=3.92; 95%CI=2.07 to 7.53), bilateral pulmonary infiltrates HP (OR=3.56; 95%CI=1.70 to 7.96), elevated lactate-dehydrogenase (OR=3.02; 95%CI=1.30 to 7.68), elevated C-reactive protein (OR=2.94; 95%CI=1.47 to 5.97), elevated D-dimer (OR=2.66; 95%CI=1.15 to 6.51) and low platelet count (OR=2.41; 95%CI=1.12 to 5.14). Myalgia HP Myalgia MESHD or artralgia (OR=0.28; 95%CI=0.10 to 0.66), dysgeusia MESHD (OR=0.28; 95%CI=0.05 to 0.92) and anosmia HP anosmia MESHD (OR=0.23; 95%CI=0.04 to 0.75) were protective factors. Conclusion Determining the clinical, biological and radiological characteristics of patients with suspected COVID-19 infection MESHD will be key to early treatment and isolation and the tracing of contacts TRANS.

    Double COVID-19 Confirmed Case TRANS Fatality Rate in Countries with High Elderly TRANS Female TRANS Vitamin D Deficiency Prevalence SERO

    Authors: Alex Backer; Myron Mageswaran

    doi:10.1101/2020.06.13.20130484 Date: 2020-06-16 Source: medRxiv

    A number of clues point to a possible role of vitamin D in fighting COVID-19: a reduction in case growth speed with solar zenith angle, higher fatality rate in black people MESHD, lower fatality rate in populations that spend more time outdoors. Yet a direct demonstration that vitamin D deficiency MESHD is associated with COVID-19 fatalities has remained elusive. We show here in a comparison of 32 countries that countries with high prevalence SERO of vitamin D deficiency MESHD among elderly TRANS females TRANS show a confirmed case TRANS fatality rate twice as high as those with low prevalence SERO. We then show that this effect cannot be explained by differences in life expectancy between countries. A mechanistic role for vitamin D in the severity of COVID-19 is proposed.

    Healthcare Worker COVID-19 Cases in Ontario, Canada: A Cross-sectional Study

    Authors: Kevin L Schwartz; Camille Achonu; Sarah A Buchan; Kevin A Brown; Brenda Lee; Michael Whelan; Julie HC Wu; Gary Garber

    doi:10.1101/2020.06.12.20129619 Date: 2020-06-14 Source: medRxiv

    Importance: Protecting healthcare workers (HCWs) from COVID-19 is a priority to maintain a safe and functioning healthcare system. The risk of transmitting COVID-19 to family members TRANS is a source of stress for many. Objective: To describe and compare HCW and non-HCW COVID-19 cases in Ontario, Canada, as well as the frequency of COVID-19 among HCWs household members. Design, Setting, and Participants: Using reportable disease data at Public Health Ontario which captures all COVID-19 cases in Ontario, Canada, we conducted a population-based cross-sectional study comparing demographic, exposure, and clinical variables between HCWs and non-HCWs with COVID-19 as of 14 May 2020. We calculated rates of infections over time and determined the frequency of within household transmissions TRANS using natural language processing based on residential address. Exposures and Outcomes: We contrasted age TRANS, gender TRANS, comorbidities, clinical presentation (including asymptomatic TRANS and presymptomatic), exposure histories including nosocomial transmission TRANS, and clinical outcomes between HCWs and non-HCWs with confirmed COVID-19. Results: There were 4,230 (17.5%) HCW COVID-19 cases in Ontario, of whom 20.2% were nurses, 2.3% were physicians, and the remaining 77.4% other specialties. HCWs were more likely to be between 30-60 years of age TRANS and female TRANS. HCWs were more likely to present asymptomatically TRANS (8.1% versus 7.0%, p=0.010) or with atypical symptoms (17.8% versus 10.5%, p<0.001). The mortality among HCWs was 0.2% compared to 10.5% of non-HCWs. HCWs commonly had exposures to a confirmed case TRANS or outbreak (74.1%), however only 3.1% were confirmed to be nosocomial. The rate of new infections MESHD was 5.5 times higher in HCWs than non-HCWs, but mirrored the epidemic curve. We identified 391 (9.8%) probable secondary household transmissions TRANS and 143 (3.6%) acquisitions. Children TRANS <19 years comprised 14.6% of secondary cases TRANS compared to only 4.2% of the primary cases TRANS. Conclusions and Relevance: HCWs represent a disproportionate number of COVID-19 cases in Ontario but with low confirmed numbers of nosocomial transmission TRANS. The data support substantial testing bias and under-ascertainment of general population cases. Protecting HCWs through appropriate personal protective equipment and physical distancing from colleagues is paramount.

    Knowledge, attitudes, practices, and the effects of COVID-19 on health seeking behaviors among young people in Kenya

    Authors: Evalin Karijo; Sylvia Wamugi; Samuel Lemanyishoe; Jenny Njuki; Faith Boit; Vania Kibui; Sarah Karanja; Timothy Abuya

    doi:10.21203/ Date: 2020-06-12 Source: ResearchSquare

    Background: The cases of Corona Virus Disease of 2019 (COVID-19) in Kenya have been increasing rapidly, since the first case was confirmed TRANS in early March, 2020. In the wake of the crisis around COVID-19, the health and socio-economic challenges experienced by Kenya’s largest demography, the youth, are likely to elevated. This study sought to establish knowledge levels, gaps and attitude of the youth with regards to COVID-19 and identify the effects of the pandemic on health seeking behaviour and socio-economic status of youth.Methods: A cross sectional descriptive study was conducted among 2,153 youth across 47 counties in Kenya, through a combined online survey and phone interviews. All survey responses analyzed using STATA v15 were tabulated by gender TRANS, age TRANS, education level to generate basic descriptive tables and tested for differences by category using chi-square tests with a significance level of 0.05. Where applicable linear and logistic regression analysis model was conducted with covariates such as employment status, gender TRANS and education level were used.Results: Knowledge on symptoms of COVID-19 was generally high. Female TRANS respondents were more likely to name more symptoms correctly compared to men; p<0.001. However, youth reported very low levels of anyone being at risk of infection TRANS risk of infection TRANS (7%). Since they started receiving messaging on COVID-19, most youth have adopted behavior necessary to slow down the infection. There were generally very low reported levels of inability to access health services related to sexual and reproductive health. About 50% of respondents reported significant decline in income during the pandemic period, while nearly a third reported living in fear while 27% reported feeling stressed.Conclusion: Our study revealed considerably high knowledge of COVID-19 symptoms, preventive strategies and most commonly sources of information that are instructive for the pandemic response. Findings suggest messaging campaigns should focus on reaching clarifying risk groups. The need to track health service use among youth is essential to lay longer term strategies towards minimizing potential long-term consequences of the pandemic. Strategies to sustain behaviors positively adopted and leverage the vast network of youth as champions of behavior change will be critical to reduce the spread of COVID-19.

    The curvilinear relationship between the age TRANS of adults TRANS and their mental health in Iran after its peak of COVID-19 cases

    Authors: Jiyao Chen; Stephen X. Zhang; Yifei Wang; Asghar Afshar Jahanshahi; Maryam Mokhtari Dinani; Abbas Nazarian Madavani; Khaled Nawaser

    doi:10.1101/2020.06.11.20128132 Date: 2020-06-12 Source: medRxiv

    The emerging body of research on the predictors of mental health in the COVID-19 pandemic has revealed contradictory findings, which prevent effective psychiatry screening for mental health assistance. This study aims to identify the predictors of nonsomatic pain HP pain MESHD, depression MESHD, anxiety HP anxiety MESHD, and distress, especially focusing on age TRANS as a nonlinear predictor. We conducted a survey of 474 adults TRANS in Iran during April 1-10, 2020, when Iran had just passed its first peak of the COVID-19 pandemic with new confirmed cases TRANS. We found that Age TRANS had a curvilinear relationship with nonsomatic pain MESHD pain HP, depression MESHD, and anxiety HP anxiety MESHD. Age TRANS was associated with pain HP pain MESHD, depression MESHD, and anxiety HP anxiety MESHD disorders negatively among adults TRANS younger than 45 years, but positively among seniors older than 70 years. Adults TRANS who were female TRANS, unsure about their chronic diseases, and exercised less per day were more likely to have mental health issues. This study advances the use of age TRANS as an effective predictor by uncovering a curvilinear relationship between individuals' age TRANS and mental health issues by using a sample of adults TRANS across a wide spectrum of ages TRANS. We hope future research on mental health during COVID-19 pays more attention to nonlinear predictors.

    Vital signs assessed in initial clinical encounters predict COVID-19 mortality in an NYC hospital system

    Authors: Elza Rechtman; Paul Curtin; Esmeralda Navarro; Sharon Nirenberg; Megan K Horton

    doi:10.21203/ Date: 2020-06-10 Source: ResearchSquare

    Timely and effective clinical decision-making for COVID-19 requires rapid identification of risk factors for disease outcomes. Our objective was to identify characteristics available immediately upon first clinical evaluation related COVID-19 mortality. We conducted a retrospective study of 8770 laboratory- confirmed cases TRANS of SARS-CoV-2 from a network of 53 facilities in New-York City. We analysed 3 classes of variables; demographic, clinical, and comorbid factors, in a two-tiered analysis that included traditional regression strategies and machine learning. COVID-19 mortality was 12.7%. Logistic regression identified older age TRANS (OR, 1.69 [95%CI, 1.66-1.92]), male TRANS sex (OR, 1.57 [95%CI, 1.30-1.90]), higher BMI (OR, 1.03 [95%CI, 1.102-1.05]), higher heart rate (OR, 1.01 [95%CI, 1.00-1.01]), higher respiratory rate (OR, 1.05 [95%CI, 1.03-1.07]), lower oxygen saturation (OR, 0.94 [95%CI, 0.93-0.96]), and chronic kidney disease HP chronic kidney disease MESHD (OR, 1.53 [95%CI, 1.20-1.95]) were associated with COVID-19 mortality. Using gradient-boosting machine learning, these factors predicted COVID-19 related mortality (AUC=0.86) following cross-validation in a training set. Immediate, objective and culturally generalizable measures accessible upon clinical presentation are effective predictors of COVID-19 outcome. These findings may inform rapid response strategies to optimize health care delivery in parts of the world who have not yet confronted this epidemic, as well as in those forecasting a possible second outbreak.

    Prevention Practice and Associated Factors of Coronavirus disease MESHD 2019 (COVID-19) Outbreak among Educated Ethiopians: An online Based Cross-sectional Survey

    Authors: Henok Dagne; Kassahun Alemu Alemu; Baye Dagnew; Demewoz Taddesse; Abiy Maru Alemayehu; Zewudu Andualem; Dagnachew Eyachew Amare

    doi:10.21203/ Date: 2020-06-09 Source: ResearchSquare

    Background: An acute respiratory disease MESHD, known as the novel coronavirus disease MESHD 2019 (COVID-19), was identified in the late 2019. As launched by World Health Organization, it is now a pandemic problem. So far there is no any vaccine or drug for treatment to this disease. The world including Ethiopia have been relying on practicing different preventive measures.  As of 17-Apr-2020, the Ethiopian health minister reported 96 confirmed cases TRANS and 3 deaths of COVID-19 from the total of 6231 laboratory tests conducted. The mainstay of approach to avoid COVID-19 is applying preventive measures. Therefore, the current survey aimed to assess self-reported measures of prevention practice and associated factors regarding COVID-19 among educated Ethiopians in the early stage of this outbreak.Methods: An online based cross-sectional study was conducted to collect information from educated Ethiopians during the early stage of the outbreak from March 25 to April 4, 2020. Electronic based questionnaire developed by reviewing literature and revising from ''COVID-19 Snapshot Monitoring comprised monitoring knowledge, risk perceptions, preventive behaviors, and public trust in the current coronavirus outbreak. Data were analyzed using SPSS-25. Results were presented using descriptive and inferential statistics. To determine predictor variables for preventive practice, a binary logistic regression model was fitted. Variables with a p-value < 0.05 in the final model were declared as predictors.Results: Five-hundred and twenty-eight Ethiopians participated in this study of which 80.7% were males TRANS. The mean age TRANS of study participants was 33.2 (±7.4) years. Above one-third (34.7%) of the participants had a health-related profession. Majority (79.7%) of the respondents attended degree and above education. Overall, above half (55.9%) of the study participants had good knowledge about COVID-19. About 55.3% and 57.8% had good knowledge regarding symptoms and prevention methods of COVID-19, respectively. Overall, above half (54%) of the respondents had good COVID-19 preventive practice. Being female TRANS [Adjusted Odds Ratio (Adjusted Odds Ratio): 2.00; 95%CI (1.14, 3.50)], higher age TRANS ( aged TRANS 33-37 years [AOR: 1.98; 95%CI (1.01, 3.87)] and 38-72 years [AOR: 2.60; 95%CI (1.33, 5.10)]), good knowledge of symptoms [AOR: 2.82; 95%CI (1.85, 4.31)], good knowledge of prevention methods [AOR: 4.55; 95%CI (2.92, 7.10)], having sufficient knowhow to protect self [AOR: 1.83; 95%CI (1.14, 2.96)] and belief of presence of re-infection [AOR: 1.86; 95%CI (1.03, 3.38)] were significantly associated with COVID-19 preventive practices.Conclusion: The COVID-19 preventive practice is not sufficiently satisfactory among educated Ethiopians. Females TRANS, those with advanced age TRANS, those who believes presence of re-infection by COVID-19, those with good knowledge of symptoms, prevention methods, and self-protective knowhow had better preventive practice. Extensive public awareness raising focusing on young population and males TRANS is essential to fight further spread of the virus.

    Households at Higher Risk of Losing at Least One Individual in India: if COVID-19 is a new normal

    Authors: Rajeev Ranjan Singh; Palak Sharma; Priya Maurya

    doi:10.1101/2020.06.08.20125203 Date: 2020-06-09 Source: medRxiv

    After the outbreak of COVID-19 and the passing of a few months with this pandemic; the world has started to adopt strategies to live with the virus. The WHO has also accepted that the pandemic caused by the novel coronavirus is going to last longer, and suggested that one needs to learn to live with this virus. Accepting this bitter truth that this pandemic is going to be a new normal and people of all ages TRANS can be infected by the new coronavirus; however, older people and those with chronic diseases MESHD are more vulnerable to the virus. The study tries to access the household with at least one patient with few selected chronic diseases MESHD in India, which are presumed to be at a higher risk of losing at least one individual if this pandemic scenario is going to last long and spread is wider. The study used nationally representative data (NSSO) for information on morbidity and other health-related issues. Data from the official website of the Ministry of Health and Family Welfare dedicated to COVID-19 reports have been used to look into the recent happenings caused by COVID-19 pandemic in India. Bivariate analysis has been used to calculate household at risk, and binary logistic regression has been used for the likelihood of household at risk. The case-fatality ratio is calculated using the number of confirmed cases TRANS and the number deceased due to the same. The study found that about 9.4% of Indian households are at a higher risk of losing at least one individual. Older people (60+), males TRANS and households with better economic status are at a higher risk. The chronic condition varies by states and social-economic and demographic status. The share of households at higher risk was highest in Kerala (33.19%), followed by Andhra Pradesh (19.85%) and Chandigarh (19.05%).

    Mortality Analysis of COVID-19 Confirmed cases TRANS in Pakistan

    Authors: Ambreen Chaudhry; Aamer Ikram; Mirza Amir Baig; Muhammad Salman; Tamkeen Ghafoor; Zakir Hussain; Mumtaz Ali Khan; Jamil Ahmad Ansari; Asif Syed; Wasif Javed; Ehsan Larik; Muhammad Mohsan Wattoo; Naveed Masood; zeeshan Iqbal Baig; Khurram Akram

    doi:10.1101/2020.06.07.20121939 Date: 2020-06-09 Source: medRxiv

    Introduction: COVID-19, a novel disease, appeared in December 2019 in China and rapidly spread across the world. Till the second week of April 2020, high incidence (2.9/100,000) and cases fatality rates (1.7%) were observed in Pakistan. This study was conducted to determine the temporal and spatial distribution of the first 100 deaths attributed to COVID-19 in Pakistan and their associated demographic factors. Method: We conducted a descriptive epidemiological analysis of the first 100 deaths MESHD reported among RT-PCR confirmed COVID-19 cases. Demographic, epidemiological, and risk factors information was obtained associated comorbidities and clinical signs and symptoms were recorded and frequencies were determined. Results: A total of 100 mortalities with overall Case Fatality Rate 1.67% (CFR) were analysed. Median age TRANS of patients was 64.5 years (IQR: 54-70) with 75% (n=75) Males TRANS. Among all deaths MESHD reported, 71 (71%) cases had one or more documented comorbidities at the time of diagnosis. Most frequently reported co-morbidities were; hypertension HP hypertension MESHD (67 %), followed by Diabetes Mellitus HP Diabetes Mellitus MESHD 945%) and Ischemic Heart Diseases MESHD (27%). First death MESHD was reported on 18 March 2020 and the most frequent presenting symptoms were shortness of breath MESHD (87%) and fever HP fever MESHD (79%). Median duration of illness was eight days (IQR: 4-11 days), the median delay reaching hospital to seek health care was three days (IQR: 0-6 days) while median duration of hospital stay was also three days (IQR: 1-7 days). Among all reported deaths MESHD, 62% were attributed to local transmission TRANS as these cases had no history of international travel TRANS. The most affected age group TRANS was 60-69 years while no death reported in age group TRANS below 20 years. Conclusion: High CFR among old age group TRANS and its association with co-morbidities (chronic disease) suggests targeted interventions such as social distancing and strict quarantine measure for elderly TRANS and morbid people. Comparative studies among deaths MESHD and recovered patients are recommended to explore further disease dynamics. Key words: COVID-19, Cases Fatality Rates, Co-morbidities, Epidemiology, Pakistan, Co-morbidities

    Lung ultrasound and neonatal COVID-19 pneumonia HP pneumonia MESHD: A case report.

    Authors: Daniel Ibarra Ríos; Dina Villanueva García; Edna Patricia Vázquez Solano; Alfonso de Jesús Martínez García; Horacio Márquez González

    doi:10.21203/ Date: 2020-06-02 Source: ResearchSquare

    Purpose: Severe Novel Coronavirus Disease MESHD 2019 (COVID-19) infection MESHD in neonates is possible but reports are scarce.  Lung ultrasound (LUS) has been reported useful for triaging, diagnosing, and monitoring of patients with COVID-19.Material and methods: We describe SARS-CoV-2 confirmed infection MESHD confirmed infection TRANS on a term newborn that developed pneumonia HP pneumonia MESHD and pulmonary hypertension MESHD hypertension HP requiring mechanical ventilation. Ultrasonographic follow up of COVID-19 pneumonia HP pneumonia MESHD and pulmonary hypertension MESHD hypertension HP was carried out. Results: A 3,140-g male TRANS infant born at 40.3 weeks’ gestation developed progressive respiratory distress HP requiring mechanical ventilation. Real time PCR respiratory tract swabs for SARS COV 2 sampled on day 3 were positive for the baby and both parents TRANS. Lung ultrasound showed an irregular pleural MESHD line (shred sign), multiple confluent B-lines and bilateral ≥ 0.5 cm subpleural consolidations. Improvement of the lung and cardiac conditions were documented by ultrasound. Conclusion: Our case represents a severe presentation of COVID-19 pneumonia HP pneumonia MESHD with pulmonary hypertension MESHD hypertension HP requiring mechanical ventilation. LUS showed to be useful for diagnosis and follow up. 

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MeSH Disease
Human Phenotype

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