Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
    displaying 1 - 5 records in total 5
    records per page




    Epidemiological and clinical characteristics of COVID-19 in Indian children TRANS in the initial phase of the pandemic: A cross-sectional study

    Authors: Bhakti Sarangi; Venkat Sandeep Reddy; Jitendra S. Oswal; Nandini Malshe; Ajinkya Patil; Manojit Chakraborty; Sanjay Lalwani

    doi:10.21203/rs.3.rs-36303/v1 Date: 2020-06-17 Source: ResearchSquare

    Background: India saw the largest and the most stringent lockdown in the world when the number of COVID-19 cases reached around 550. With some early benefits in containing the surge and restricting the R0 TRANS of the virus, the current relaxation of lockdown norms has witnessed an exponential rise in positive cases. With scarcity of Pediatric data from the Indian subcontinent, early observations in the pandemic are pivotal in improving the understanding of physiologic behaviors, identifying risks, and guiding clinicians in assessing time-tested interventions and augmenting the awareness in the masses about the manifold clinical profiles of an evolving disease.Objective: To assess the epidemiological and clinical characteristics of children TRANS admitted with COVID-19 infection MESHD early in the pandemic.Study Design: A cross-sectional studyParticipants: Fifty children TRANS between one month and 18 years of age TRANS whose nasopharyngeal swab tested positive for SARS-CoV-2 by RT- PCR. Results: 28 (56%) children TRANS were male TRANS. 41 (82%) came from government declared containment zones with only one child TRANS having history of travel TRANS to affected area. Home overcrowding was observed in 33 (66%). Of the 50 children TRANS, 29 (58%) were asymptomatic TRANS while 20 (40%) and one (2%) had mild and moderate symptoms respectively. Fever HP Fever MESHD, cough HP cough MESHD, and sore throat were the most common symptoms. 49 (98%) children TRANS had BCG scar HP. Leucopenia was seen in three (6%) only. Mean (SD) Neutrophil-Lymphocyte-Ratio (NLR) was 0.78 (0.48) while mean (SD) CRP was 10.98 (23.90). All 50 (100%) were cured. Conclusion: Our study reasserts the increasing pediatric burden of COVID-19 with all age groups TRANS affected and overcrowding as a risk factor for continued community transmission TRANS, thus beckoning that public health policies be directed to ensuring further preventive measures. It also re-iterates the milder disease pattern in children TRANS with COVID-19 in the initial phase of the pandemic with a high proportion of asymptomatic TRANS and mild illness. Though abnormal CRP values are synonymous with the illness in children TRANS; leucopenia may not be a consistent finding.  

    Epidemiologic, Clinical, and Laboratory Findings of the COVID-19 in the current pandemic: Systematic Review and Meta-analysis

    Authors: Yewei Xie; Zaisheng Wang; Huipeng Liao; Gifty Marley; Dan Wu; Weiming Tang

    doi:10.21203/rs.3.rs-28367/v2 Date: 2020-05-11 Source: ResearchSquare

    Background: The COVID-19 pandemic has affected the world deeply, with more than 3,000,000 people infected and nearly 200,000 deaths. This review aimed to summarize the epidemiologic traits, clinical spectrum, CT results and laboratory findings of the COVID-19 pandemic.Methods: We scoped for relevant literatures published during 1st Dec 2019 to 23rd Apr 2020 based on four databases using English and Chinese languages. We reviewed and analyzed the relevant clinic outcomes of COVID-19.Results: The COVID-19 pandemic was found to have a higher transmission TRANS rate compared to SARS and MERS MESHD and involved 4 stages of evolution. The basic reproduction number TRANS ( R0 TRANS) is 3.32 (95% CI:3.24-3.39), the incubation period TRANS was 5.24 days (95% CI:3.97-6.50, 5 studies) on average, and the average time for symptoms onset TRANS varied by countries. Common clinical spectrums identified included fever HP fever MESHD (38.1-39.0℃), cough HP cough MESHD and fatigue HP fatigue MESHD, with Acute Respiratory Distress Syndrome MESHD Respiratory Distress HP Syndrome ( ARDS MESHD) being the most common complication reported. Body temperatures above 39.0 ℃, dyspnea HP dyspnea MESHD, and anorexia HP anorexia MESHD were more common symptoms in severe patients. Aged TRANS over 60 years old, having co-morbidities, and developing complications were the commonest high-risk factors associated with severe conditions. Leucopenia and lymphopenia HP lymphopenia MESHD were the most common signs of infection MESHD while liver and kidney damage MESHD were rare but may cause bad outcomes for patients. The bilateral, multifocal Ground-Glass Opacification (GGO) on peripheral, and the consolidative pulmonary opacity HP were the most frequent CT results and the tendency of mortality rates differed by region.Conclusions: We provided a bird’s-eye view of the COVID-19 during the current pandemic, which will help better understanding the key traits of the disease. The findings could be used for disease’s future research, control and prevention.

    Epidemiologic, Clinical, and Laboratory Findings of the COVID-19 in the current pandemic: Systematic Review and Meta-analysis

    Authors: Yewei Xie; Zaisheng Wang; Huipeng Liao; Gifty Marley; Dan Wu; Weiming Tang

    doi:10.21203/rs.3.rs-28367/v3 Date: 2020-05-11 Source: ResearchSquare

    Background: The COVID-19 pandemic has affected the world deeply, with more than 3,000,000 people infected and nearly 200,000 deaths. This review aimed to summarize the epidemiologic traits, clinical spectrum, CT results and laboratory findings of the COVID-19 pandemic. Methods: We scoped for relevant literatures published during 1 st Dec 2019 to 23 rd Apr 2020 based on four databases using English and Chinese languages. We reviewed and analyzed the relevant clinic outcomes of COVID-19. Results: The COVID-19 pandemic was found to have a higher transmission TRANS rate compared to SARS and MERS MESHD and involved 4 stages of evolution. The basic reproduction number TRANS (R 0 ) is 3.32 (95% CI:3.24-3.39), the incubation period TRANS was 5.24 days (95% CI:3.97-6.50, 5 studies) on average, and the average time for symptoms onset TRANS varied by countries. Common clinical spectrums identified included fever HP fever MESHD (38.1-39.0℃), cough HP cough MESHD and fatigue HP fatigue MESHD, with Acute Respiratory Distress Syndrome MESHD Respiratory Distress HP Syndrome ( ARDS MESHD) being the most common complication reported. Body temperatures above 39.0 ℃, dyspnea HP dyspnea MESHD, and anorexia HP anorexia MESHD were more common symptoms in severe patients. Aged TRANS over 60 years old, having co-morbidities, and developing complications were the commonest high-risk factors associated with severe conditions. Leucopenia and lymphopenia HP lymphopenia MESHD were the most common signs of infection MESHD while liver and kidney damage MESHD were rare but may cause bad outcomes for patients. The bilateral, multifocal Ground-Glass Opacification (GGO) on peripheral, and the consolidative pulmonary opacity HP were the most frequent CT results and the tendency of mortality rates differed by region. Conclusions: We provided a bird’s-eye view of the COVID-19 during the current pandemic, which will help better understanding the key traits of the disease. The findings could be used for disease’s future research, control and prevention.

    Epidemic Peak for COVID-19 in India, 2020

    Authors: Chaitanya S. Wagh; Parikshit N. Mahalle; Sanjeev J. Wagh

    id:10.20944/preprints202005.0176.v1 Date: 2020-05-10 Source: Preprints.org

    In India the first case of coronavirus disease MESHD 2019 (COVID-19) reported on 30 January 2020, and thereafter cases were increasing daily after the last week of Feb. 2020. COVID-19 identified as family member TRANS of coronaviridae where previously Middle East Respiratory Syndrome MERS and Severe Acute Respiratory Syndrome SARS belongs MESHD to same family. The COVID-19 attacks on respiratory system signing fever HP fever MESHD, cough HP cough MESHD and breath shortness MESHD, in severe cases may cause pneumonia HP pneumonia MESHD, SARS or some time death MESHD. The aim of this study work is to develop model which predicts the epidemic peak for COVID-19 in India by using the real-time data from 30 Jan to 10 May 2020. There are uncertainties while identifying the population information due to the incomplete and inaccurate data, we initiate the most popular model for epidemic prediction i.e Susceptible, Exposed, Infectious, & Recovered SEIR initially the compartmental model for the prediction. Based on the solution of the state estimation problem for polynomial system with Poisson noise, we estimate that the epidemic peak may reach the early-middle July 2020, initializing recovered R0 TRANS to 0 and Infected I0 to 1. The outcomes of the model will help epidemiologist to isolate the source of the disease geospatially and analyze the death. Also government authorities will be able to target their interventions for rapidly checking the spread of the epidemic.

    Exit strategies: optimising feasible surveillance for detection, elimination and ongoing prevention of COVID-19 community transmission TRANS

    Authors: Kamalini Lokuge; Emily Banks; Stephanie Davis; Leslee Roberts; Tatum Street; Grazia Caleo; Kathryn Glass

    doi:10.1101/2020.04.19.20071217 Date: 2020-04-23 Source: medRxiv

    Background Following successful implementation of strong containment measures by the community, Australia is now close to the point of eliminating detectable community transmission TRANS of COVID-19. We aimed to develop an efficient, rapid and scalable surveillance strategy for detecting all remaining COVID-19 community transmission TRANS through exhaustive identification of every active transmission chain TRANS. We also identified measures to enable early detection and effective management of any reintroduction of transmission TRANS once containment measures are lifted to ensure strong containment measures do not need to be reinstated. Methods We compared efficiency and sensitivity SERO to detect community transmission chains TRANS through testing of: hospital cases; primary TRANS care fever HP fever MESHD and cough HP cough MESHD patients; or asymptomatic TRANS community members, using surveillance evaluation methods and mathematical modelling, varying testing capacities and prevalence SERO of COVID-19 and non-COVID-19 fever HP fever MESHD and cough HP cough MESHD, and the reproduction number TRANS. System requirements for increasing testing to allow exhaustive identification of all transmission chains TRANS, and then enable complete follow-up of all cases and contacts within each chain, were assessed per million population. Findings Assuming 20% of cases are asymptomatic TRANS and all symptomatic COVID-19 cases present to primary care, with high transmission TRANS (R=2.2) there are a median of 13 unrecognised community cases (5 infectious) when a transmission chain TRANS is identified through hospital surveillance versus 3 unrecognised cases (1 infectious) through primary care surveillance. 3 unrecognised community upstream community cases themselves are estimated to generate a further 22-33 contacts requiring follow-up. The unrecognised community cases rise to 5 if only 50% of symptomatic cases present to primary care. Screening for asymptomatic TRANS disease in the community cannot exhaustively identify all transmission TRANS under any of the scenarios assessed. The additional capacity required to screen all fever HP fever MESHD and cough HP primary care patients would be approximately 2,000 tests/million population per week using 1/16 pooling of samples. Interpretation Screening all syndromic fever MESHD fever HP and cough HP primary care presentations, in combination with exhaustive and meticulous case and contact identification and management, enables appropriate early detection and elimination of community transmission TRANS of COVID-19. If testing capacity is limited, interventions such as pooling allow increased case detection, even given reduced test sensitivity SERO. Wider identification and testing of all upstream contacts, (i.e. potential sources of infection MESHD for identified cases, and their related transmission chains TRANS) is critical, and to be done exhaustively requires more resources than downstream contact tracing TRANS. The most important factor in determining the performance SERO of such a surveillance system is community participation in screening and follow up, and as such, appropriate community engagement, messaging and support to encourage presentation and compliance is essential. We provide operational guidance on implementing such a system.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
Human Phenotype
Transmission
Seroprevalence


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.