Corpus overview


Overview

MeSH Disease

Human Phenotype

Dementia (1)

Delirium (1)


Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Frailty and mortality in hospitalized older adults TRANS with COVID-19: retrospective observational study

    Authors: Robert De Smet; Bea Mellaerts; Hannelore Vandewinckele; Peter Lybeert; Eric Frans; Sara Ombelet; Wim Lemahieu; Rolf Symons; Erwin Ho; Johan Frans; Annick Smismans; Michael R Laurent

    doi:10.1101/2020.05.26.20113480 Date: 2020-05-27 Source: medRxiv

    Background: Older adults TRANS with coronavirus disease MESHD 2019 (COVID-19) face an increased risk of adverse health outcomes including mortality. Ethical guidelines consider allocation of limited resources based on likelihood of survival, frailty, co-morbidities and age TRANS. However, the association of frailty with clinical outcomes in older COVID-19 patients remains unclear. Objectives: To determine the association between frailty and short-term mortality in older adults TRANS hospitalized for COVID-19. Design: Retrospective single-center observational study. Setting and participants: N = 81 patients with COVID-19 confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR), at the Geriatrics department of Imelda general hospital, Belgium. Measurements: Frailty was graded according to the Rockwood Clinical Frailty Scale (CFS). Demographic, biochemical and radiological variables, co-morbidities, symptoms and treatment were extracted from electronic medical records. Results: Participants (N = 48 women, 59%) had a median age TRANS of 85 years (range 65 - 97 years), median CFS score of 7 (range 2 - 9), and 42 (52%) were long-term care residents. Within six weeks, eighteen patients died. Mortality was significantly but weakly associated with age TRANS (Spearman r = 0.241, P = 0.03) and CFS score (r = 0.282, P = 0.011), baseline lactate dehydrogenase (LDH) (r = 0.301, P = 0.009), lymphocyte count (r = -0.262, P = 0.02) and RT-PCR Ct value (r TRANS = -0.285, P = 0.015). Mortality was not associated with long-term care residence, dementia HP dementia MESHD, delirium HP delirium MESHD or polypharmacy. In multivariable logistic regression analyses, CFS, LDH and RT-PCR Ct values (but not age TRANS) remained independently associated with mortality. Both age TRANS and frailty had poor specificity to predict survival. A multivariable model combining age TRANS, CFS, LDH and viral load significantly predicted survival. Conclusions and implications: Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID-19, if sufficient resources are available.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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