Corpus overview


MeSH Disease

Human Phenotype

Conjunctivitis (5)

Cough (3)

Fever (3)

Fatigue (3)

Chemosis (1)


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    Fighting COVID-19 spread among nursing home residents even in absence of molecular diagnosis: a retrospective cohort study.

    Authors: Alessio Strazzulla; Paul Tarteret; Maria Concetta Postorino; Marie Picque; Astrid de Pontfarcy; Nicolas Vignier; Catherine Chakvetadze; Coralie Noel; Cecile Drouin; Zine Eddine Benguerdi; Sylvain Diamantis

    doi:10.21203/ Date: 2020-07-30 Source: ResearchSquare

    Background Access to molecular diagnosis was limited out-of-hospital in France during the 2020 coronavirus disease 2019 (COVID-19) epidemic. This study describes the evolution of COVID-19 outbreak in a nursing home in absence of molecular diagnosis. Methods A monocentric prospective study was conducted in a French nursing home from March 17th, 2020 to June 11th, 2020. Because of lack of molecular tests for severe acute respiratory syndrome 2 (SARS-Cov2) infection MESHD, probable COVID-19 cases were early identified considering only respiratory and not-respiratory symptoms and therefore preventing measures and treatments were enforced. Once available, serology tests were performed at the end of the study.A chronologic description of new cases and deaths MESHD was made together with a description of COVID-19 symptoms. Data about personal characteristics and treatments were collected and the following comparisons were performed: i) probable COVID-19 cases vs asymptomatic TRANS residents; ii) SARS-Cov2 seropositive residents vs seronegative residents. Results Overall, 32/66 (48.5%) residents and 19/39 (48.7%) members of health-care personnel were classified as probable COVID-19 cases. A total of 34/61 (55.7%) tested residents resulted seropositive. Death occurred in 4/66 (6%) residents. Diagnosis according to symptoms had 65% of sensitivity SERO, 78% of specificity, 79% of positive predictive value SERO and 64% of negative predictive value SERO.In resident population, the following symptoms were registered: 15/32 (46.8%) lymphopenia HP lymphopenia MESHD, 15/32 (46.8%) fever HP fever MESHD, 8/32 (25%) fatigue HP fatigue MESHD, 8/32 (25%) cough HP, 6/32 (18.8%) diarrhoea MESHD, 4/32 (12.5%) severe respiratory distress HP requiring oxygen therapy, 4/32 (12.5%) fall HP, 3/32 (9.4%) conjunctivitis HP conjunctivitis MESHD, 2/32 (6.3%) abnormal pulmonary noise at chest examination and 2/32 (6,25%) abdominal pain HP abdominal pain MESHD. Probable COVID-19 cases were older (81.3 vs 74.9; p=0.007) and they had higher prevalence SERO of atrial fibrillation HP atrial fibrillation MESHD (8/32, 25% vs 2/34, 12%; p=0.030); insulin treatment (4/34, 12% vs 0, 0%; p=0.033) and positive SARS-Cov2 serology (22/32, 69% vs 12/34, 35%; p=0.001) than asymptomatic TRANS residents. Seropositive residents had lower prevalence SERO of diabetes MESHD (4/34, 12% vs 9/27, 33%; p=0.041) and angiotensin-converting-enzyme inhibitors’ intake (1/34, 1% vs 5/27, 19%; p=0.042). Conclusions During SARS-Cov2 epidemic, early detection of respiratory and not-respiratory symptoms allowed to enforce extraordinary measures. They achieved limiting contagion and deaths among nursing home residents, even in absence of molecular diagnosis.

    The Prevalence SERO of ocular manifestations and ocular samples polymerase chain reaction positivity in patients with COVID 19 - a systematic review and meta-analysis

    Authors: Soumen Sadhu; Sushmitha Arcot Dandapani; Deepmala Mazumdar; Sangeetha Srinivasan; Jyotirmay Biswas

    doi:10.1101/2020.06.29.20142414 Date: 2020-06-30 Source: medRxiv

    Objective: To estimate the prevalence SERO of ocular manifestations and ocular samples polymerase chain reaction (PCR) positivity among COVID 19 patients. Methods: A systematic literature review was performed using search engines (PubMed, Google Scholar, Medrixv and BioRixv) with keywords SARS CoV MESHD 2, novel coronavirus, COVID 19, ocular manifestations, conjunctival congestion, Ocular detection, Polymerase chain reaction, and conjunctivitis HP conjunctivitis MESHD. The measure of heterogeneity was evaluated with the I2 statistic. The pooled proportion of patients presenting with symptoms and ocular samples PCR positivity was estimated. Results: A total of 20 studies (14 studies and 6 case reports) were included in the systematic review and 14 studies were included in the metaanalysis. The pooled prevalence SERO of conjunctivitis HP conjunctivitis MESHD was 5.17% (95% CI: 2.90 to 8.04). Conjunctivitis HP Conjunctivitis MESHD was reported as an initial symptom of the disease in 0.858 % (95% CI: 0.31 to 1.67). Common associated features include itching, chemosis HP chemosis MESHD, epiphora HP. Seven patients (29 %) with conjunctivitis HP conjunctivitis MESHD showed positive results in ocular samples, whereas 13 patients (54%) showed positive only in their nasopharyngeal samples (NPs) or sputum samples and 4 patients (16 %) were negative for both NPs and Sputum as well as ocular samples. The pooled prevalence SERO of ocular PCR positivity was 2.90 % (95% CI: 1.77 to 4.46) vs. NPs 89.8% (95% CI: 78.80 to 79.0). Conclusion: The prevalence SERO of conjunctivitis HP conjunctivitis MESHD and ocular samples PCR positivity among COVID 19 patients was low indicating that the eye is a less affected organ. However, conjunctivitis HP conjunctivitis MESHD may present as the first symptom of the disease making the patient seek medical care at the earliest.

    Type and frequency of ocular and other known symptoms experienced by people who self diagnosed as suffering from COVID-19 in the UK

    Authors: Shahina Pardhan; Megan Vaughan; Jufen Zhang; Lee Smith; Havovi Chichger

    doi:10.1101/2020.06.20.20134817 Date: 2020-06-22 Source: medRxiv

    Background: Recent literature suggests that ocular manifestations present in people suffering from COVID-19. However, the prevalence SERO and the type of ocular symptoms varies substantially, and most studies report retrospective data from patients suffering from more serious versions of the disease. Little is known of exactly which ocular symptoms manifest in people with milder forms of COVID-19. Methods: An online questionnaire obtained self-report data from people in the community, who reported to be inflicted with COVID-19. The type and frequency of different symptoms suffered during COVID-19 were obtained. Details of any pre-existing ocular conditions and the duration of symptoms of COVID-19 were ascertained. Results: Data from 132 participants showed that the four most reported COVID-19 symptoms were Dry Cough HP (63%), Fever HP Fever MESHD (67%), Fatigue HP (83%), and loss of Smell/Taste (63%). 56% of the participants reported to having experienced an eye symptom, 46% reported to having a new or different eye symptom compared to pre-COVID-19 state. Three ocular symptoms (watery eyes, sore eyes, sensitivity SERO to light) were significantly different from Pre-COVID-19 state (p<0.05). Logistic regression showed a significant association of eye symptoms with Fever HP Fever MESHD (p=0.035). Conclusion: Nearly half of the sample of people studied experienced ocular symptoms. The significant ocular symptoms, indicative of viral conjunctivitis MESHD conjunctivitis HP, might have been missed in patients with more serious manifestations of the disease. It is also important to differentiate between the types of ocular manifestation, as symptoms of bacterial conjunctivitis MESHD conjunctivitis HP (i.e. mucous discharge, gritty eyes) were not significant. Possible mechanisms for SARS-CoV-2 infection MESHD within the eye are discussed.

    Sociodemographic profile, clinical characteristics, anxiety HP anxiety MESHD, and depression MESHD of 74 patients infected with COVID-19: first report from Bangladesh

    Authors: Dr. Mohammad Jahid Hasan; Dr. Md. Abdullah Saeed Khan; Dr. Monjur Rahman; Dr. Md. Shahnoor Islam; Dr Sourav Debnath; Dr. Jannatul Fardous,; Professor Dr. Mohammad Robed Amin

    doi:10.21203/ Date: 2020-05-30 Source: ResearchSquare

    Background: The pandemic of Corona Virus Disease MESHD 2019 (COVID-19) has cost a large number of lives and is causing substantial mental stress among people. We conducted a study to identify the sociodemographic and clinical characteristics and prevalence SERO of anxiety HP anxiety MESHD and depression MESHD among confirmed COVID-19 cases in Bangladesh.Methods: An online cross-sectional survey using a preformed questionnaire adapted in Google form was conducted for data collection. The form was shared along with a brief introduction and rationale via Facebook, Twitter, Facebook Messenger, Viber, and What’s App. Formal ethical clearance was taken from the Biomedical Research Foundation, Bangladesh. Informed consent was ensured before participation.Results: Seventy-four patients with COVID-19 who had an average age TRANS of 42.59±14.43 years with male TRANS predominance (77%) were included. A total of 29.7% were doing health-care related jobs, and 14.9% lost their jobs due to COVID-19. Patients had a median income of BDT 30000. Of all, 87.8% of patients were symptomatic and presented with fever HP fever MESHD (77%), cough HP (58.8%), breathlessness (24.3%), myalgia HP myalgia MESHD (24.3%), sore throat (21.6%), fatigue HP fatigue MESHD (17.6%), nausea and/or vomiting HP nausea and/or vomiting MESHD (12.2%), headache HP headache MESHD (12.2%), runny nose (9.5%), chest pain HP chest pain MESHD (9.5%), diarrhea HP diarrhea MESHD (8.1%), ARDS (2.7%), stuffy nose (2.7%), conjunctivitis HP conjunctivitis MESHD (1.4%) and oral ulcer HP oral ulcer MESHD (1.4%). Overall, the prevalence SERO of anxiety HP anxiety MESHD and depression was 60% and 52.9%, respectively. Among the participants, 11.4% had only anxiety HP anxiety MESHD, 4.3% had only depression MESHD and 48.6% had both.Conclusion: Patients were mostly middle aged TRANS, male TRANS and healthy workers. Typical presentations were fever HP fever MESHD and cough HP cough MESHD. Nearly two-thirds of the patients had either or both anxiety HP anxiety MESHD and depression.

    COVID-19 experience: first Italian survey on healthcare staff members from a Mother- Child TRANS Research hospital using combined molecular and rapid immunoassays SERO test

    Authors: Manola Comar; Marco Brumat; Maria Pina Concas; Giorgia Argentini; Annamonica Bianco; Livia Bicego; Roberta Bottega; Petra Carli; Andrea Cassone; Eulalia Catamo; Massimiliano Cocca; Massimo Del Pin; Mariateresa Di Stazio; Agnese Feresin; Martina La Bianca; Sara Morassut; Anna Morgan; Giulia Pelliccione; Vincenzo Petix; Giulia Ragusa; Antonietta Robino; Stefano Russian; Beatrice Spedicati; Sarah Suergiu; Marianela Urriza; Fulvia Vascotto; Paola Toscani; Giorgia Girotto; Paolo Gasparini

    doi:10.1101/2020.04.19.20071563 Date: 2020-04-22 Source: medRxiv

    The fast spread of the novel coronavirus (SARS-CoV-2) has become a global threat hitting the worldwide fragile health care system. In Italy, there is a continued COVID-19 growth of cases and deaths MESHD that requires control measures for the correct management of the epidemiological emergency. To contribute to increasing the overall knowledge of COVID-19, systematic tests in the general population are required. Here, we describe the first Italian survey performed in 727 employees belonging to a Mother- Child TRANS Research hospital tested for both viral (nasopharyngeal and oropharyngeal swabs) and antibody SERO presence. Individuals were divided into three risk categories (high, medium and low) according to their job activity. Only one subject was positive at the swab test while 17.2% of the cohort was positive for the presence of antibodies SERO. Results highlighted that the presence of Positive antibodies SERO is significantly associated with high and medium risk exposure occupation (p-value=0.026) as well as cold and conjunctivitis HP conjunctivitis MESHD symptoms (p-value=0.016 and 0.042 respectively). Moreover, among healthcare professionals, the category of medical doctors showed a significant association with the presence of antibodies SERO against SARS-CoV-2 (p-value=0.0127). Finally, we detected a rapid decrease in antibody SERO intensity between two assessments performed within a very short period (p-value=0.009). Overall, the present study increases our knowledge of the epidemiological data of COVID-19 infection MESHD in Italy, suggesting a high prevalence SERO of immune individuals (i.e. at least among at-risk categories) and the efficacy of the combined diagnostic protocol to monitor the possible outbreak.

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MeSH Disease
Human Phenotype

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