Corpus overview


Overview

MeSH Disease

Human Phenotype

Confusion (2)

Anxiety (1)


Transmission

Seroprevalence
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    'Trained immunity' from Mycobacterium spp. exposure or BCG vaccination and COVID-19 outcomes

    Authors: Samer Singh; Rajendra P. Maurya; Rakesh K. Singh

    doi:10.1101/2020.07.11.20151308 Date: 2020-07-14 Source: medRxiv

    Protective variables for COVID-19 are unknown. 'Trained immunity' of the populace as a result of BCG policy implementation and coverage had been suggested to be one of the factors responsible for the differential impact of COVID-19 on different countries. Several trials are underway to evaluate the potential protective role of BCG vaccination in COVID-19. However, the lack of clarity on the use of appropriate controls concerning 'trained immunity' has been a cause of concern leading to more confusion HP confusion MESHD as exemplified by a recently concluded trial in Israel that failed to find any correlation. Whereas, when we analyze the COVID-19 data of European countries without any mandatory BCG vaccination policy but with similar age TRANS distribution, comparable confounding variables, and the stage of the pandemic, the prevalence SERO of Mycobacterium spp.(including BCG vaccine) exposure of the populations is consistently negatively correlated with COVID-19 infections per million population at all the time points evaluated [r(20): -0.5511 to -0.6338; p-value: 0.0118 to 0.0027]. The results indicate that the on-going and future studies evaluating the effect of BCG vaccination on COVID-19 outcomes should consider the inclusion of 'controls' for underlying 'trained immunity' prevalence SERO or that resulting from the intervention (BCG vaccine) in such trials to arrive at more dependable conclusions.

    Psychological responses, behavioral changes and public perceptions during the early phase of the COVID-19 outbreak in China: a population based cross-sectional survey

    Authors: Mengcen Qian; Qianhui Wu; Peng Wu; Zhiyuan Hou; Yuxia Liang; Benjamin J Cowling; Hongjie Yu

    doi:10.1101/2020.02.18.20024448 Date: 2020-02-20 Source: medRxiv

    Objective: To investigate psychological MESHD and behavioral responses to the threat of SARS-CoV-2 infections MESHD and their associations with public perceptions in China Design: Cross sectional population-based telephone survey via random digital dialing between 1 and 10 February, 2020 Setting: Wuhan (the epicentre and quarantined city), and Shanghai (a typical major city with close transportation link with Wuhan) Participants: Random sample of 510 residents in Wuhan and 501 residents in Shanghai aged TRANS above 18 Main outcome measures: Anxiety HP Anxiety MESHD (measured by the 7-item generalized anxiety HP anxiety MESHD disorder [GAD-7] scale), recommended and avoidance behaviors (engaged in all six behaviors such as increasing surface cleaning and reducing going out). Results: The prevalence SERO rates of moderate or severe anxiety HP anxiety MESHD (score [≥]10 on GAD-7) were 32.7% (n=167) among Wuhan participants and 20.4% (n=102) among Shanghai participants. 78.6% (n=401) of Wuhan participants and 63.9% (n=320) of Shanghai participants had carried out all six precautionary behaviors. For both measures, Wuhan participants were more responsive to the outbreak (p<0.001). Controlling for personal characteristics, logistic regression results suggested that risks of moderate or severe anxiety HP anxiety MESHD were positively associated with perceived susceptibility (odds ratio 1.6, 95% confidence interval 1.3-1.8) and severity of the disease (1.6, 1.4-1.9) and confusion HP confusion MESHD about information reliability (1.6, 1.5-1.9). Having confidence in taking measures to protect oneself against the disease was associated with a lower risk (0.6, 0.5-0.7). The strongest predictor of behavioral change was perceived severity (1.2, 1.1-1.4), followed by confusion HP confusion MESHD about information reliability (1.1, 1.0-1.3). Conclusions: Psychological and behavioral responses to COVID-19 have been dramatic during the rising phase of the outbreak. Our results support efforts for timely dissemination of accurate and reliable information to address the high anxiety HP anxiety MESHD level.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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