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Overview

MeSH Disease

Human Phenotype

Transmission

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Seroprevalence
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    Blood SERO Type Distribution in Autoimmune Diseases MESHD: An Anonymous, Large-Scale, Self-Report Pilot Study

    Authors: Edward S Harris; Harlan D Harris; Miroslav Malkovsky

    doi:10.21203/rs.3.rs-75388/v1 Date: 2020-09-10 Source: ResearchSquare

    Background: Recent research has verified that blood SERO group or Rh factor can influence susceptibility to various cardiovascular, neoplastic and infectious diseases MESHD including COVID-19. While a number of studies have looked at correlations between blood SERO group and various rheumatological diseases MESHD, findings have been inconsistent, often because many of these studies suffered from small sample size issues. In order to better understand the potential relationships between blood SERO group/Rh factor and rheumatological diseases MESHD, we performed a large-scale self-report pilot study of blood SERO type distributions in five autoimmune diseases MESHD.Methods: Five autoimmune diseases MESHD were included in the study: systemic sclerosis MESHD, systemic lupus erythematosus HP systemic lupus erythematosus MESHD, rheumatoid arthritis HP rheumatoid arthritis MESHD, psoriasis MESHD, and ankylosing spondylitis MESHD. We also included a control group in which participants did not have any autoimmune diseases MESHD.  The participants were recruited through social media and organizations such as the Lupus Foundation and the National Psoriasis Foundation. Respondents who met the inclusion criteria were asked only two questions by anonymous survey: blood SERO type and country of birth.Results: Each autoimmune disorder MESHD group included between 570 and 951 US participants. While there was little difference in blood SERO type distribution patterns among the five diseases, unexpectedly, all five disease groups showed a consistent pattern where Rh negative was almost twice as high as US population norms. A post-hoc non-autoimmune control group was added in order to determine if this anomalous finding was an artifact of the study design. The control group displayed a similar unexpected increase in the Rh-negative blood SERO type prevalence SERO, suggesting that the very high Rh-negative frequency among the tested disease groups was likely to be an artifact of the study design. Conclusions: Overall, our preliminary study results show no meaningful differences between the disease groups and the post-hoc control group, suggesting that neither ABO type nor Rh factor affects susceptibility to the development of any of the five studied autoimmune diseases MESHD. Nevertheless, the unexpected observed difference in Rh factor distribution between the studied groups/control group and the corresponding US population norms has important implications for any research study using self-selected subjects.  Our results suggest that such studies may be subject to unanticipated biases, requiring meticulous controls to confirm impartiality and exclude any artifacts of the study design.

    Angiotensin-converting enzyme 2, a SARS-CoV-2 receptor, is upregulated by interleukin-6 via STAT3 signaling in rheumatoid MESHD synovium

    Authors: Sho Mokuda; Tadahiro Tokunaga; Junya Masumoto; Eiji Sugiyama

    doi:10.1101/2020.05.26.115261 Date: 2020-05-27 Source: bioRxiv

    Detected in December 2019, the coronavirus disease MESHD 2019 (COVID-19) has since spread all over the world, resulting in a global pandemic. The disease is caused by severe acute respiratory syndrome-coronavirus-2 MESHD (SARS-CoV-2), and its symptoms usually include cough HP, fever HP fever MESHD, and gastrointestinal problems MESHD. Although the prevalence SERO of rheumatoid arthritis HP rheumatoid arthritis MESHD ( RA MESHD) is about 1 % of the global population and RA MESHD patients naturally have a chance of acquiring COVID-19 in this pandemic, no studies have considered the expression of angiotensin-converting enzyme 2 (ACE2) (a receptor for SARS-CoV-2) in synovial tissues. Our presenting data revealed that ACE2 expression was elevated in active rheumatoid MESHD synovium, and siRNA against STAT3 was able to downregulate ACE2 expression, which was in turn induced by IL-6 signaling.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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