Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence
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    Coronavirus Disease MESHD (COVID-19) and the Liver: A comprehensive systematic review and meta-analysis

    Authors: Praveen Kumar-M; Shubhra Mishra; Daya Krishna Jha; Jayendra Shukla; Arup Choudhury; Ritin Mohindra; Harshal S Mandavdhare; Usha Dutta; Vishal Sharma

    doi:10.21203/rs.3.rs-37723/v1 Date: 2020-06-24 Source: ResearchSquare

    Background: Liver function derangements have been reported in coronavirus disease MESHD (COVID-19) but reported rates are variable. Methods: We searched Pubmed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence SERO, stratified prevalence SERO based on severity, estimated risk ratio (RR) and estimated standardized mean difference (SMD) of liver function parameters in severe as compared to nonsevere COVID. Random effect method utilizing inverse variance approach was used for pooling the data. Results: In all, 128 studies were included. The most frequent abnormalities were hypoalbuminemia HP hypoalbuminemia MESHD [61.27% (48.24 - 72.87)], elevations of gamma-glutamyl transferase (GGT) [27.94%(18.22 -40.27)], alanine aminotransferase (ALT) [23.28%(19.92 - 27.01)] and aspartate aminotransferase (AST) [23.41%(18.84 - 28.70)]. Further the relative risk of these abnormalities was higher in the patients with severe COVID-19 when compared to non-severe disease [ Hypoalbuminemia HP Hypoalbuminemia MESHD - 2.65(1.38 - 5.07); GGT - 2.31(1.6 - 3.33); ALT - 1.76(1.44 - 2.15); AST 2.30(1.82 - 2.90)]. The SMD of hypoalbuminemia HP hypoalbuminemia MESHD, GGT, ALT and AST elevation in severe as compared to nonsevere were -1.05(-1.27 - -0.83), 0.76(0.40 - 1.12), 0.42(0.27 - 0.56) and 0.69 (0.52 - 0.86) respectively. The pooled prevalence SERO and RR of chronic liver disease MESHD as a comorbidity was 2.64% (1.73- 4) and 1.69(1.05-2.73) respectively. Conclusion: The most frequent abnormality in liver HP functions was hypoalbuminemia HP hypoalbuminemia MESHD followed by derangements in gamma-glutamyl transferase and aminotransferases and these abnormalities were more frequent in severe disease.  The systematic review was, however, limited by heterogeneity in definitions of severity and liver function derangements.  

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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