Corpus overview


Overview

MeSH Disease

Human Phenotype

Anemia (3)

Obesity (1)

Hepatitis (1)

Shock (1)

Hypertension (1)


Transmission

Seroprevalence
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    Red blood SERO cell distribution width (RDW) in Hospitalized COVID-19 Patients

    Authors: Preethi Ramachandran; Mahesh Gajendran; Abhilash Perisetti; Karim Osama Elkholy; Abhishek Chakraborti; Giuseppe Lippi; Hemant Goyal

    doi:10.1101/2020.06.29.20143081 Date: 2020-07-03 Source: medRxiv

    Introduction: Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2), is causing dramatic morbidity and mortality worldwide. The Red Blood SERO Cell Distribution Width (RDW) has been strongly associated with increased morbidity and mortality in multiple diseases. Objective: To assess if elevated RDW is associated with unfavorable outcomes in hospitalized COVID-19. Methods: We retrospectively studied clinical outcomes of hospitalized COVID-19 patients for their RDW values. In-hospital mortality was defined as primary outcome, while septic shock MESHD shock HP, need for mechanical ventilation, and length of stay (LOS) were secondary outcomes. Results- A total of 294 COVID-19 patients were finally studied. Overall prevalence SERO of increased RDW was 49.7% (146/294). RDW was associated with increased risk of in-hospital mortality (aOR, 4.5; 95%CI, 1.4-14.3) and septic shock MESHD shock HP (aOR, 4.6; 95%CI, 1.4-15.1) after adjusting for anemia HP anemia MESHD, ferritin, and lactate. The association remained unchanged even after adjusting for other clinical confounders such as age TRANS, sex, body mass index, coronary artery disease MESHD, hypertension HP hypertension MESHD, diabetes mellitus HP diabetes mellitus MESHD, and chronic obstructive pulmonary disease HP chronic obstructive pulmonary disease MESHD. No association was found instead with mechanical ventilation and median LOS. Conclusion: Elevated RDW in hospitalized COVID-19 patients is associated with a significantly increased risk of mortality and septic shock MESHD shock HP.

    Anemia HP Anemia MESHD and iron metabolism in COVID-19: A systematic review and meta-analysis

    Authors: Petek Eylul Taneri; Sergio Alejandro Gomez-Ochoa; Erand Llanaj; Peter Francis Raguindin; Lydia Z. Rojas; Beatrice Minder Wyssmann; Doris Kopp-Heim; Wolf E. Hautz; Michele F. Eisenga; Oscar H. Franco; Marija Glisic; Taulant Muka

    doi:10.1101/2020.06.04.20122267 Date: 2020-06-05 Source: medRxiv

    Iron metabolism and anemia HP anemia MESHD may play an important role in multiple organ dysfunction syndrome MESHD in Coronavirus disease MESHD 2019 (COVID-19). If confirmed, this has important implications for the more than 1.62 billion people estimated to have anemia HP anemia MESHD globally. We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia HP anemia MESHD and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and prevalence SERO of anemia HP anemia MESHD) in patients diagnosed with COVID-19, and explore their prognostic value. Six bibliographic databases were searched up to May 5th 2020. We included 56 unique studies, with data from 14,044 COVID-19 patients (59 years median age TRANS). Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages TRANS were 130.41 g/L (95% Confidence Interval (CI), 128.42; 132.39) and 673.91 ng/mL (95% CI, 420.98; 926.84), respectively. Hemoglobin levels decreased with advancing age TRANS and increasing percentage of comorbid and critically ill MESHD patients, while levels of ferritin increased with increasing male TRANS proportion and mean hemoglobin levels. Compared to moderate cases, severe cases had lower pooled mean hemoglobin [weighted mean difference (WMD), -4.21 (95% CI -6.63; -1.78)] and higher ferritin [WMD, -730.55 ng/mL (95% CI 413.24; 1047.85)]. A significant difference in mean ferritin level of 1027.23 ng/mL (95% CI 819.53; 1234.94) was found between survivors and non-survivors, but not in hemoglobin levels. No studies provided information on anemia HP anemia MESHD or other biomarkers of interest. Future studies should explore the impact of iron metabolism and anemia HP anemia MESHD and in the pathophysiology, prognosis, and treatment of COVID-19.

    COVID-19 transmission risk TRANS factors

    Authors: Alessio Notari; Giorgio Torrieri

    doi:10.1101/2020.05.08.20095083 Date: 2020-05-12 Source: medRxiv

    We analyze risk factors correlated with the initial transmission TRANS growth rate of the recent COVID-19 pandemic in different countries. The number of cases follows in its early stages an almost exponential expansion; we chose as a starting point in each country the first day with 30 cases and we used 12 days, capturing thus the early exponential growth. We looked then for linear correlations of the exponents with other variables, for a sample of 126 countries. We find a positive correlation, faster spread of COVID-19 , with high confidence level with the following variables, with respective p-value: low Temperature (4x10 -7), high ratio of old vs. working- age TRANS people (3x10 -6), life expectancy (8x10 -6), number of international tourists (1x10 -5), earlier epidemic starting date (2x10 -5), high level of physical contact in greeting habits (6x10 -5), lung cancer MESHD prevalence SERO (6x10 -5), obesity HP obesity MESHD in males TRANS (1x10 -4), share of population in urban areas (2x10 -4), cancer MESHD prevalence SERO (3x10 -4), alcohol consumption (0.0019), daily smoking prevalence SERO (0.0036), UV index (0.004, smaller sample, 73 countries), low Vitamin D serum SERO levels (0.002-0.006, smaller sample, 50 countries). There is highly significant correlation also with blood SERO type: positive correlation with types RH- (2x10 -5) and A+ (2x10 -3), negative correlation with B+ (2x10 -4). We also find positive correlation with moderate confidence level (p-value of 0.02-0.03) with: CO2/SO emissions, type-1 diabetes MESHD in children TRANS, low vaccination coverage for Tuberculosis MESHD (BCG). Several of the above variables are correlated with each other and so they are likely to have common interpretations. Other variables are found to have a counterintuitive negative correlation, which may be explained due their strong negative correlation with life expectancy: slower spread of COVID-19 is correlated with high death-rate due to pollution, prevalence SERO of anemia HP anemia MESHD and hepatitis HP hepatitis MESHD B, high blood SERO pressure in females TRANS. We also analyzed the possible existence of a bias: countries with low GDP-per capita, typically located in warm regions, might have less intense testing and we discuss correlation with the above variables.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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