Corpus overview


Overview

MeSH Disease

Diarrhea (6)

Fever (5)

Fatigue (4)

Nausea (4)

Vomiting (4)


Human Phenotype

Transmission

Seroprevalence
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    Gastrointestinal symptoms in coronavirus disease MESHD 2019: a cross-sectional study in Wuhan, China

    Authors: Yong Zhang; Zuneng Lu; Bo Wang; Jinxing Chang; Yonggang Ma

    doi:10.21203/rs.3.rs-69884/v1 Date: 2020-09-01 Source: ResearchSquare

    Background To investigate the clinical symptoms of coronavirus disease MESHD 2019 (COVID-19), particularly the prevalence SERO, time of symptom onset TRANS, and duration of gastrointestinal ( GI MESHD) symptoms.Methods This was a cross-sectional study using paper questionnaires. COVID-19 patients in a temporary hospital in Wuhan voluntarily completed surveys collecting data on COVID-19 symptoms and investigation results.Results A total of 212 adults TRANS were enrolled in this study, of whom 127 (59.9%) were female TRANS, mean age TRANS was 48.50 ± 13.15 years. Concerning symptoms, 78.8% (167/212) had fever HP fever MESHD, and 66% (140/212) had cough HP. Diarrhoea MESHD occurred in 43.8% (93/212) of patients. Nausea and vomiting HP Nausea and vomiting MESHD vomiting MESHD were also common (20.7%). Fever HP Fever MESHD and cough HP cough MESHD were frequently the initial symptoms of COVID-19, and they lasted for 5.00 [interquartile range (IQR): 3.00–10.00] days and 10.00 (IQR: 5.00–24.00) days, respectively. Most patients developed nausea and vomiting HP nausea and vomiting MESHD vomiting MESHD 2.00 (IQR: 0–9.00) days and diarrhoea MESHD 5.00 (IQR: 0.25–11.00) days after the onset of initial symptoms, respectively. There was a median duration of 4.00 (IQR: 2.00–8.75) days with diarrhoea MESHD, and 6.00 (IQR: 4.00–10.00) days with nausea and vomiting HP nausea and vomiting MESHD vomiting MESHD. The patients with diarrhoea MESHD were younger [45.85 ± 13.28 years vs 50.61 ± 12.82 years, P = 0.009] and were more likely to have an abnormal chest CT (95.7% vs 82.4%, P = 0.001) than those without diarrhoea MESHD.Conclusions In our cohort of patients, GI symptoms MESHD were common in COVID-19, occurred mostly during the middle stage of the disease, and lasted for a short duration. GI MESHD symptoms may not be associated with COVID-19 related treatment.

    Community prevalence SERO of SARS-CoV-2 virus in England during May 2020: REACT study

    Authors: Steven Riley; Kylie E. C. Ainslie; Oliver Eales; Benjamin Jeffrey; Caroline E. Walters; Christina J Atchison; Peter J. Diggle; Deborah Ashby; Christl A. Donnelly; Graham Cooke; Wendy Barclay; Helen Ward; Graham Taylor; Ara Darzi; Paul Elliott

    doi:10.1101/2020.07.10.20150524 Date: 2020-07-11 Source: medRxiv

    Background England has experienced one of the highest rates of confirmed COVID-19 mortality in the world. SARS-CoV-2 virus has circulated in hospitals, care homes and the community since January 2020. Our current epidemiological knowledge is largely informed by clinical cases with far less understanding of community transmission TRANS. Methods The REal-time Assessment of Community Transmission TRANS (REACT) study is a nationally representative prevalence SERO survey of SARS-CoV-2 virus swab-positivity in the community in England. We recruited participants regardless of symptom status. Results We found 159 positives from 120,610 swabs giving an average prevalence SERO of 0.13% (95% CI: 0.11%,0.15%) from 1st May to 1st June 2020. We showed decreasing prevalence SERO with a halving time of 8.6 (6.2, 13.6) days, implying an overall reproduction number TRANS R of 0.57 (0.45, 0.72). Adults TRANS aged TRANS 18 to 24 yrs had the highest swab-positivity rates, while those >64 yrs had the lowest. Of the 126 participants who tested positive with known symptom status in the week prior to their swab, 39 reported symptoms while 87 did not, giving an estimate that 69% (61%,76%) of people were symptom-free for the 7 days prior testing positive in our community sample. Symptoms strongly associated with swab-positivity were: nausea and/or vomiting HP nausea and/or vomiting MESHD vomiting MESHD, diarrhoea MESHD, blocked nose, loss of smell, loss of taste MESHD, headache HP headache MESHD, chills HP and severe fatigue HP fatigue MESHD. Recent contact with a known COVID-19 case was associated with odds of 24 (16, 38) for swab-positivity. Compared with non-key workers, odds of swab-positivity were 7.7 (2.4, 25) among care home (long-term care facilities) workers and 5.2 (2.9, 9.3) among health care workers. However, some of the excess risk associated with key worker status was explained by recent contact with COVID-19 cases. We found no strong evidence for geographical variability in positive swab results. Conclusion Our results provide a reliable baseline against which the impact of subsequent relaxation of lockdown can be assessed to inform future public health efforts to control transmission TRANS.

    COVID-19-like symptoms and their relation to SARS-CoV-2 epidemic in children TRANS and adults TRANS of an Italian birth cohort

    Authors: Maja Popovic; Chiara Moccia; Elena Isaevska; Giovenale Moirano; Costanza Pizzi; Daniela Zugna; Franca Rusconi; Franco Merletti; Milena Maule; Lorenzo Richiardi

    doi:10.21203/rs.3.rs-34027/v1 Date: 2020-06-08 Source: ResearchSquare

    Background Emerging COVID-19 pandemic caused extensive lockdowns in a number of countries, but yet unknown number of cases positive to SARS-CoV-2 escapes surveillance systems. Methods Mothers participating in an Italian NINFEA birth cohort were invited to complete an online questionnaire on COVID-19-like symptoms in the household. We estimated the population prevalence SERO of COVID-19-like symptoms in children TRANS and adults TRANS, assessed their geographical correlation with the cumulative number of COVID-19 cases by province, analysed their clustering within families, and estimated their sensitivity SERO, positive (PPV) and negative predictive values SERO (NPV) for COVID-19 diagnosis in individuals tested for SARS-CoV-2.Results Information was collected on 3184 households, 6133 adults TRANS, and 5751 children TRANS. There was a strong geographical correlation between the population cumulative incidence of COVID-19 and the prevalence SERO of muscle pain MESHD pain HP, fatigue HP fatigue MESHD, low-grade fever HP fever MESHD, and breathing difficulties in adults TRANS (Spearman’s rho ≥0.70). Having at least one family member TRANS with a COVID-19 diagnosis, compared with none tested for SARS-CoV-2, was associated with an increased prevalence SERO ratio of almost all COVID-19-like symptoms in adults TRANS, and only of low-grade fever HP (37-37.5oC; prevalence SERO ratio 5.27; 95% confidence intervals: 2.37 to 11.74) and anosmia HP anosmia MESHD/dysgeusia in children TRANS. Among adults TRANS with COVID-19, fatigue HP fatigue MESHD, muscle pain MESHD pain HP, and fever HP fever MESHD had a sensitivity SERO ≥70%. In individuals tested for SARS-CoV-2, with a 16.6% prevalence SERO of COVID-19, breathing difficulties and nausea/vomiting HP nausea/vomiting MESHD vomiting MESHD had the highest PPVs, with point estimates close to 60%, and with NPVs close to 90%. Among tested Piedmont residents, with a COVID-19 prevalence SERO of 18.5%, breathing difficulties and anosmia HP anosmia MESHD/disguesia reached PPVs above 80%.Conclusion Geographical prevalence SERO of COVID-19-like symptoms in adults TRANS may inform on local disease clusters, while certain symptoms in family members TRANS of confirmed COVID-19 cases could help identification of the intra-familial spread of the virus and its further propagation in the community. Low-grade fever HP is frequent in children TRANS with at least one household member with COVID-19 and possibly indicates child TRANS infection.  

    Epidemiological approximation of the enteric manifestation and possible fecal-oral transmission TRANS in COVID-19: A preliminary systematic review

    Authors: Javier Pamplona, PhD; Rubén Solano, PhD; Cristina Soler, MD; Miriam Sàbat, PhD

    doi:10.21203/rs.3.rs-33873/v1 Date: 2020-06-05 Source: ResearchSquare

    Objectives: to conduct a systematic review to describe the epidemiological scientific evidence on gastrointestinal symptoms MESHD ( GIS MESHD), enteric involvement and fecal excretion of SARS-CoV-2 viral RNA and to discuss the possible fecal-oral transmission TRANS pathway of COVID-19.Methods: We have reviewed GIS MESHD, enteric involvement, and fecal test results of SARS CoV-2 from case reports and retrospective observational studies related to the digestive system published about the outbreak.Results: The prevalence SERO of GIS MESHD in patients infected with SARS CoV-2 ranges from 1.7% (1/56)-100% (10/10), GIS MESHD included diarrhea HP diarrhea MESHD 1/99(1%)-8/10(80%), nausea/vomiting HP nausea/vomiting MESHD 1/28(3.6%)-5/10 (50%), abdominal pain HP abdominal pain MESHD 2/103(1.9%)-1/3(33.3%). A total of 3% of infected MESHD patients may experience GIS MESHD in the absence of respiratory symptoms. A pooled analysis of the results showed 16.1% GIS MESHD, 8.3% diarrhea HP diarrhea MESHD and 12% nausea-vomiting HP nausea-vomiting MESHD. A higher percentage of diarrhea HP diarrhea MESHD in patients with severe disease (5.8%) than in non-severe disease (3.5%), and a more severe course in patients with GIS MESHD (22.97%) than in those without GIS MESHD (8.12%) was found. Histological studies demonstrated the presence of ACE2 receptors and the nucleocapsid of the virus in gastrointestinal. The RNA of the virus has been detected in 27-53% of patients with COVID-19 in whom respiratory and stool samples have been analyzed, and it may persist in stool for up to an average of 11.2 days after negativization of the respiratory samples.Conclusions: GIS MESHD are common in SARS CoV-2 infection MESHD at the time of patient admission, sometimes represent the only clinical manifestation. Infection of the GI MESHD tract is possible due to the presence of ACE2 receptors, and there may be viral replication with fecal elimination.

    Sociodemographic profile, clinical characteristics, anxiety HP anxiety MESHD, and depression MESHD of 74 patients infected with COVID-19: first report from Bangladesh

    Authors: Dr. Mohammad Jahid Hasan; Dr. Md. Abdullah Saeed Khan; Dr. Monjur Rahman; Dr. Md. Shahnoor Islam; Dr Sourav Debnath; Dr. Jannatul Fardous,; Professor Dr. Mohammad Robed Amin

    doi:10.21203/rs.3.rs-32517/v1 Date: 2020-05-30 Source: ResearchSquare

    Background: The pandemic of Corona Virus Disease MESHD 2019 (COVID-19) has cost a large number of lives and is causing substantial mental stress among people. We conducted a study to identify the sociodemographic and clinical characteristics and prevalence SERO of anxiety HP anxiety MESHD and depression MESHD among confirmed COVID-19 cases in Bangladesh.Methods: An online cross-sectional survey using a preformed questionnaire adapted in Google form was conducted for data collection. The form was shared along with a brief introduction and rationale via Facebook, Twitter, Facebook Messenger, Viber, and What’s App. Formal ethical clearance was taken from the Biomedical Research Foundation, Bangladesh. Informed consent was ensured before participation.Results: Seventy-four patients with COVID-19 who had an average age TRANS of 42.59±14.43 years with male TRANS predominance (77%) were included. A total of 29.7% were doing health-care related jobs, and 14.9% lost their jobs due to COVID-19. Patients had a median income of BDT 30000. Of all, 87.8% of patients were symptomatic and presented with fever HP fever MESHD (77%), cough HP (58.8%), breathlessness (24.3%), myalgia HP myalgia MESHD (24.3%), sore throat (21.6%), fatigue HP fatigue MESHD (17.6%), nausea and/or vomiting HP nausea and/or vomiting MESHD (12.2%), headache HP headache MESHD (12.2%), runny nose (9.5%), chest pain HP chest pain MESHD (9.5%), diarrhea HP diarrhea MESHD (8.1%), ARDS (2.7%), stuffy nose (2.7%), conjunctivitis HP conjunctivitis MESHD (1.4%) and oral ulcer HP oral ulcer MESHD (1.4%). Overall, the prevalence SERO of anxiety HP anxiety MESHD and depression was 60% and 52.9%, respectively. Among the participants, 11.4% had only anxiety HP anxiety MESHD, 4.3% had only depression MESHD and 48.6% had both.Conclusion: Patients were mostly middle aged TRANS, male TRANS and healthy workers. Typical presentations were fever HP fever MESHD and cough HP cough MESHD. Nearly two-thirds of the patients had either or both anxiety HP anxiety MESHD and depression.

    Association of age TRANS, sex, comorbidities, and clinical symptoms with the severity and mortality of COVID-19 cases: a meta-analysis with 85 studies and 67299 cases

    Authors: Mohammad Safiqul Islam; Md. Abdul Barek; Md. Abdul Aziz; Tutun Das Aka; Md. Jakaria

    doi:10.1101/2020.05.23.20110965 Date: 2020-05-26 Source: medRxiv

    Background: A new pathogenic disease named COVID-19 became a global threat, first reported in Wuhan, China, in December 2019. The number of affected cases growing exponentially and now, more than 210 countries confirmed the cases TRANS. Objective: This meta-analysis aims to evaluate risk factors, the prevalence SERO of comorbidity, and clinical characteristics in COVID-19 death MESHD patients compared to survival patients that can be used as a reference for further research and clinical decisions. Methods: PubMed, Science Direct, SAGE were searched to collect data about demographic, clinical characteristics, and comorbidities of confirmed COVID-19 patients from January 1, 2020, to May 17, 2020. Meta-analysis was performed with the use of Review Manager 5.3 Results: Eighty-five studies were included in Meta-analysis, including a total number of 67,299 patients with SARS-CoV-2 infection MESHD. Males TRANS are severely affected or died than females TRANS (OR = 2.26, p < 0.00001; OR = 3.59, p < 0.00001) are severely affected, or died by COVID-19 and cases with age TRANS [≥]50 are at higher risk of death MESHD than age TRANS <50 years (OR=334.23). Presence of any comorbidity or comorbidities like hypertension HP hypertension MESHD, cardiovascular disease MESHD, diabetes MESHD, cerebrovascular disease MESHD, respiratory disease MESHD, kidney disease MESHD, liver disease MESHD, malignancy MESHD significantly increased the risk of death compared to survival (OR = 3.46, 3.16, 4.67, 2.45, 5.84, 2.68, 5.62, 2.81,2.16). Among the clinical characteristics such as fever HP fever MESHD, cough HP cough MESHD, myalgia HP myalgia MESHD, diarrhea HP diarrhea MESHD, abdominal pain HP abdominal pain MESHD, dyspnea HP dyspnea MESHD, fatigue HP fatigue MESHD, sputum production, chest tightness HP chest tightness MESHD headache HP and nausea or vomiting HP nausea or vomiting MESHD, only fatigue HP fatigue MESHD (OR = 1.31, 95%) and dyspnea HP dyspnea MESHD increased the death significantly (OR= 1.31, 4.57). The rate of death of COVID-19 cases is 0.03-times lower than the rate of survival (OR = 0.03). Conclusion Our result indicates that male TRANS patients are affected severely or died, the rate of death is more in the age TRANS [≥]50 group, and the rate of death is affected by comorbidities and clinical symptoms.

    Gastrointestinal symptoms as Covid-19 onset in hospitalized Italian patients

    Authors: Elisabetta Buscarini; Guido Manfredi; Gianfranco Brambilla; Fernanda Menozzi; Claudio Londoni; Saverio Alicante; Elena Iiritano; Samanta Romeo; Marianna Pedaci; Giampaolo Benelli; Ciro Canetta; Giuseppe Lapiana; Alessandro Scartabellati; Guido Merli; Giovanni Vigano; Roberto Sfogliarini; Giovanni Melilli; Roberto Assandri; Daniele Cazzato; Davide Sebastiano Rossi; Susanna Usai; Irene Tramacere; Germano Pellegata; Giuseppe Lauria

    doi:10.1101/2020.04.20.20064873 Date: 2020-04-23 Source: medRxiv

    Objective To assess the prevalence SERO of gastrointestinal symptoms MESHD and their correlation with need of non-invasive ventilatory support, intensive care unit admission and death MESHD in hospitalized SARS-CoV-2 patients. Design Since February 21th 2020, all individuals referred to our emergency department for suspected SARS-CoV-2 underwent a standardized assessment of body temperature and pulse oximetry, hematological screening, chest X-ray and/or computed tomography (CT), and SARS-CoV-2 assay on nasopharyngeal swab. Medical history and GI symptoms MESHD including nausea, vomit HP nausea, vomit MESHD vomit MESHD, diarrhea HP diarrhea MESHD, and abdominal pain HP abdominal pain MESHD were recorded. Results GI symptoms MESHD were the main presentation in 42 (10.2%) of 411 patients, with a mean onset 4.9 +/-... days before admission. In 5 (1.2%) patients GI symptoms MESHD have not been associated with respiratory symptoms MESHD or fever HP fever MESHD. We found an inverse trend for ICU admission and death as compared with patients without GI symptoms MESHD. Conclusions GI symptoms MESHD can be an early and not negligible feature of Covid-19, and might be correlated with a more benign disease course.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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