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MeSH Disease

Human Phenotype

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Seroprevalence
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    Kidney impairment MESHD is associated with in-hospital death of COVID-19 patients

    Authors: Yichun Cheng; Ran Luo; Kun Wang; Meng Zhang; Zhixiang Wang; Lei Dong; Junhua Li; Ying Yao; Shuwang Ge; Gang Xu

    doi:10.1101/2020.02.18.20023242 Date: 2020-02-20 Source: medRxiv

    Background: Information on kidney impairment MESHD in patients with coronavirus disease MESHD 2019 (COVID-19) is limited. This study aims to assess the prevalence SERO and impact of abnormal urine analysis and kidney dysfunction MESHD in hospitalized COVID-19 patients in Wuhan. Method: We conducted a consecutive cohort study of COVID-19 patients admitted in a tertiary teaching hospital with 3 branches following a major outbreak in Wuhan in 2020. Hematuria HP Hematuria MESHD, proteinuria HP proteinuria MESHD, serum SERO creatinine concentration and other clinical parameters were extracted from the electronic hospitalization databases and laboratory databases. Incidence rate for acute kidney injury HP kidney injury MESHD ( AKI MESHD) was examined during the study period. Association between kidney impairment MESHD and in-hospital death was analyzed. Results: We included 710 consecutive COVID19 patients, 89 (12.3%) of whom died in hospital. The median age TRANS of the patients was 63 years (inter quartile range, 51-71), including 374 men and 336 women. On admission, 44% of patients have proteinuria HP proteinuria MESHD hematuria HP and 26.9% have hematuria HP hematuria MESHD, and the prevalence SERO of elevated serum creatinine HP serum SERO creatinine and blood SERO urea nitrogen were 15.5% and 14.1% respectively. During the study period, AKI MESHD occurred in 3.2% patients. Kaplan-Meier analysis demonstrated that patients with kidney impairment MESHD have higher risk for in-hospital death. Cox proportional hazard regression confirmed that elevated serum creatinine HP serum SERO creatinine, elevated urea nitrogen, AKI, proteinuria HP proteinuria MESHD and hematuria HP hematuria MESHD was an independent risk factor for in-hospital death after adjusting for age TRANS, sex, disease severity, leukocyte count and lymphocyte count. Conclusion: The prevalence SERO of kidney impairment MESHD ( hematuria HP hematuria MESHD, proteinuria HP proteinuria MESHD and kidney dysfunction MESHD) in hospitalized COVID-19 patients was high. After adjustment for confounders, kidney impairment MESHD indicators were associated with higher risk of in-hospital death. Clinicians should increase their awareness of kidney impairment MESHD in hospitalized COVID-19 patients.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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