Corpus overview


MeSH Disease

Human Phenotype


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    Prevalence SERO of malnutrition HP in COVID-19 inpatients: the Nutricov study

    Authors: Antoine Rouget; Fanny Vardon-Bounes; Pierre Lorber; Adrien Vavasseur; Olivier Marion; Bertrand Marcheix; Olivier Lairez; Laurent Balardy; Olivier Fourcade; Jean-Marie Conil; Vincent Minville

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: Recent ESPEN guidelines highlighted the interest of prevention, diagnosis and treatment of malnutrition HP malnutrition MESHD in the management of coronavirus disease MESHD 19 (COVID-19) patients. The aim of our study was to evaluate the prevalence SERO of malnutrition HP malnutrition MESHD in patients hospitalized for COVID-19. Methods: Prospective observational cohort study on COVID-19 inpatients admitted to a tertiary hospital. Malnutrition HP Malnutrition MESHD was diagnosed according to the Global Leadership Initiative on Malnutrition HP two-step approach. Patients were divided in two groups according to the diagnosis of malnutrition HP malnutrition MESHD. Covariate selection for the multivariate analysis was based on P value <0.2 in univariate analysis, with a logistic regression model and a backward elimination procedure. A partitioning of the population was represented using a Classification and Regression Tree analysis.Results: 80 patients were prospectively enrolled in the study. Thirty patients (37.5%) had criteria for malnutrition HP malnutrition MESHD. The need for ICU admission (n=46, 57.5%) was similar in the two groups. Three patients who died (3.75%) were malnourished. Multivariate analysis exhibited that low BMI (OR=0.83, 95% CI [0.73-0.96], p=0.0083), dyslipidemia MESHD (OR=29.45, 95% CI [3.12-277.73], p=0.0031), oral intakes reduction <50% (OR=3.169, 95% CI [1.04-9.64], p=0.0422) and GFR (CKD-EPI) at admission (OR=0.979, 95% CI [0.96-0.998], p=0.0297) were associated with the occurrence of malnutrition HP malnutrition MESHD in COVID-19 inpatients.Conclusions: We demonstrate the existence of a high prevalence SERO of malnutrition HP malnutrition MESHD (37.5%) in a general cohort of COVID-19 inpatients according to GLIM criteria. Considering this high prevalence SERO, nutritional support in COVID-19 care seems an essential element. Trial registration: Ethical Committee No 2020-A01237-32)(RC31/20/0165 NUTRI-COV

    The COVID-19 mortality effects of underlying health conditions in India: a modelling study

    Authors: Paul Novosad; Radhika Jain; Alison Campion; Sam Asher

    doi:10.1101/2020.07.05.20140343 Date: 2020-07-08 Source: medRxiv

    Objective: To model how known COVID-19 comorbidities will affect mortality rates and the age TRANS distribution of mortality in a large lower middle income country (India), as compared with a high income country (England), and to identify which health conditions drive any differences. Design: Modelling study. Setting: England and India. Participants: 1,375,548 respondents aged TRANS 18 to 99 to the District Level Household Survey-4 and Annual Health Survey in India. Additional information on health condition prevalence SERO on individuals aged TRANS 18 to 99 was obtained from the Health Survey for England and the Global Burden of Diseases, Risk Factors, and Injuries Studies (GBD). Main outcome measures: The primary outcome was the proportional increase in age TRANS-specific mortality in each country due to the prevalence SERO of each COVID-19 mortality risk factor ( diabetes MESHD, hypertension HP hypertension MESHD, obesity HP obesity MESHD, chronic heart disease MESHD, respiratory illness MESHD, kidney disease MESHD, liver disease MESHD, and cancer MESHD, among others). The combined change in overall mortality and the share of deaths under 60 from the combination of risk factors was estimated in each country. Results: Relative to England, Indians have higher rates of diabetes MESHD (10.6% vs. 8.5%), chronic respiratory disease MESHD (4.8% vs. 2.5%), and kidney disease MESHD (9.7% vs. 5.6%), and lower rates of obesity HP obesity MESHD (4.4% vs. 27.9%), chronic heart disease MESHD (4.4% vs. 5.9%), and cancer MESHD (0.3% vs. 2.8%). Population COVID-19 mortality in India relative to England is most increased by diabetes MESHD (+5.4%) and chronic respiratory disease MESHD (+2.3%), and most reduced by obesity HP obesity MESHD (-9.7%), cancer MESHD (-3.2%), and chronic heart disease MESHD (-1.9%). Overall, comorbidities lower mortality in India relative to England by 9.7%. Accounting for demographics and population health explains a third of the difference in share of deaths under age TRANS 60 between the two countries. Conclusions: Known COVID-19 health risk factors are not expected to have a large effect on aggregate mortality or its age TRANS distribution in India relative to England. The high share of COVID-19 deaths from people under 60 in low- and middle-income countries (LMICs) remains unexplained. Understanding mortality risk associated with health conditions prevalent in LMICs, such as malnutrition HP malnutrition MESHD and HIV MESHD/ AIDS MESHD, is essential for understanding differential mortality. Keywords: COVID-19, India, low- and middle-income countries, comorbidity

    Risks to Children TRANS under-five in India from COVID-19

    Authors: Isabel Frost; Katie Tseng; Stephanie Hauck; Geetanjali Kappor; Aditi Sriram; Arindam Nandi; Ramanan Laxminarayan

    doi:10.1101/2020.05.18.20105239 Date: 2020-05-22 Source: medRxiv

    Objective: The novel coronavirus, COVID-19, has rapidly emerged to become a global pandemic and is known to cause a high risk to patients over the age TRANS of 70 and those with co-morbidities, such as hypertension HP hypertension MESHD and diabetes MESHD. Though children TRANS are at comparatively lower risk compared to adults TRANS, the Indian population has a large young demographic that is likely to be at higher risk due to exposure to pollution, malnutrition HP malnutrition MESHD and poor access to medical care. We aimed to quantify the potential impact of COVID-19 on Indias child TRANS population. Methods: We combined district family household survey data with data from the COVID-19 outbreak in China to analyze the potential impact of COVID-19 on children TRANS under the age TRANS of 5, under three different scenarios; each of which assumed the prevalence SERO of infection to be 0.5%, 1%, or 5%. Results: We find that in the lowest prevalence SERO scenario, across the most populous 18 Indian states, asymptomatic TRANS, non-hospitalized symptomatic and hospitalized symptomatic cases could reach 87,200, 412,900 and 31,900, respectively. In a moderate prevalence SERO scenario, these figures reach 174,500, 825,800, and 63,800, and in the worst case, high prevalence SERO scenario these cases could climb as high as 872,200, 4,128,900 and 319,700. Conclusion: These estimates show COVID-19 has the potential to pose a substantial threat to Indias large population of children TRANS, particularly those suffering from malnutrition HP malnutrition MESHD and exposure to indoor air pollution, who may have limited access to health services.

    The Early Food Insecurity Impacts of COVID-19

    Authors: Meredith T. Niles; Farryl Bertmann; Emily H. Belarmino; Thomas Wentworth; Erin Biehl; Roni A. Neff

    doi:10.1101/2020.05.09.20096412 Date: 2020-05-13 Source: medRxiv

    Background COVID-19 has disrupted food access and impacted food insecurity, which is associated with numerous adverse individual and public health outcomes. Methods We conducted a statewide population-level survey in Vermont from March 29-April 12, 2020, during the beginning of a statewide stay-at-home order. We utilized the USDA six-item validated food security module to measure food insecurity before COVID-19 and since COVID-19. We assessed food insecurity prevalence SERO and reported food access challenges, coping strategies, and perceived helpful interventions among food secure, consistently food insecure (pre-and post COVID-19), and newly food insecure (post COVID-19) respondents. Results Among 3,219 respondents, there was a 33% increase in household food insecurity since COVID-19 (p<0.001), with 35.6% of food insecure households classified as newly food insecure. Respondents experiencing a job loss MESHD were more likely to experience food insecurity (OR 3.43; 95% CI, 2.45-4.80). Multiple physical and economic barriers, as well as concerns related to food access during COVID-19, are reported, with respondents experiencing household food insecurity more likely to face access challenges (p<0.001). Significant differences in coping strategies were documented between respondents in newly food insecure vs. consistently insecure households. Conclusions Since the declaration of the COVID-19 pandemic, there has been a significant increase in food insecurity in Vermont, accompanied by major food access barriers. These findings have important potential impacts on individual health, including mental health and malnutrition HP malnutrition MESHD, as well as on future healthcare costs. We suggest proactive strategies to address food insecurity during this crisis.

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MeSH Disease
Human Phenotype

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