Corpus overview


Overview

MeSH Disease

Myalgia (1)

Fatigue (1)

Fever (1)

Dysgeusia (1)

Nausea (1)


Human Phenotype

Pain (1)

Fatigue (1)

Low-grade fever (1)

Anosmia (1)

Fever (1)


Transmission

Seroprevalence
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    COVID-19-like symptoms and their relation to SARS-CoV-2 epidemic in children TRANS and adults TRANS of an Italian birth cohort

    Authors: Maja Popovic; Chiara Moccia; Elena Isaevska; Giovenale Moirano; Costanza Pizzi; Daniela Zugna; Franca Rusconi; Franco Merletti; Milena Maule; Lorenzo Richiardi

    doi:10.21203/rs.3.rs-34027/v1 Date: 2020-06-08 Source: ResearchSquare

    Background Emerging COVID-19 pandemic caused extensive lockdowns in a number of countries, but yet unknown number of cases positive to SARS-CoV-2 escapes surveillance systems. Methods Mothers participating in an Italian NINFEA birth cohort were invited to complete an online questionnaire on COVID-19-like symptoms in the household. We estimated the population prevalence SERO of COVID-19-like symptoms in children TRANS and adults TRANS, assessed their geographical correlation with the cumulative number of COVID-19 cases by province, analysed their clustering within families, and estimated their sensitivity SERO, positive (PPV) and negative predictive values SERO (NPV) for COVID-19 diagnosis in individuals tested for SARS-CoV-2.Results Information was collected on 3184 households, 6133 adults TRANS, and 5751 children TRANS. There was a strong geographical correlation between the population cumulative incidence of COVID-19 and the prevalence SERO of muscle pain MESHD pain HP, fatigue HP fatigue MESHD, low-grade fever HP fever MESHD, and breathing difficulties in adults TRANS (Spearman’s rho ≥0.70). Having at least one family member TRANS with a COVID-19 diagnosis, compared with none tested for SARS-CoV-2, was associated with an increased prevalence SERO ratio of almost all COVID-19-like symptoms in adults TRANS, and only of low-grade fever HP (37-37.5oC; prevalence SERO ratio 5.27; 95% confidence intervals: 2.37 to 11.74) and anosmia HP anosmia MESHD/dysgeusia in children TRANS. Among adults TRANS with COVID-19, fatigue HP fatigue MESHD, muscle pain MESHD pain HP, and fever HP fever MESHD had a sensitivity SERO ≥70%. In individuals tested for SARS-CoV-2, with a 16.6% prevalence SERO of COVID-19, breathing difficulties and nausea/vomiting HP nausea/vomiting MESHD vomiting MESHD had the highest PPVs, with point estimates close to 60%, and with NPVs close to 90%. Among tested Piedmont residents, with a COVID-19 prevalence SERO of 18.5%, breathing difficulties and anosmia HP anosmia MESHD/disguesia reached PPVs above 80%.Conclusion Geographical prevalence SERO of COVID-19-like symptoms in adults TRANS may inform on local disease clusters, while certain symptoms in family members TRANS of confirmed COVID-19 cases could help identification of the intra-familial spread of the virus and its further propagation in the community. Low-grade fever HP is frequent in children TRANS with at least one household member with COVID-19 and possibly indicates child TRANS infection.  

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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