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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Dynamic characteristics of Influenza A epidemic in children TRANS during the early stage of COVID-19 outbreak

    Authors: Xia Wang; Pin Liu; Shuwen Feng; Junwen Zhen; Yan Wu; Zhenyu Pan; Dongchi Zhao

    doi:10.21203/rs.3.rs-60623/v1 Date: 2020-08-16 Source: ResearchSquare

    Background: At the beginning of the outbreak of coronavirus infected disease MESHD 2019 (COVID-19), children TRANS in Wuhan were experiencing an extremely strong influenza A epidemic. This study is aimed to explore the epidemic dynamics characteristics of children TRANS with influenza A and its correlation with the early stage spread of COVID-19 in Wuhan.Methods: This is a retrospective single-center clinical study.From November 28, 2019 to January 23, 2020, a total of 7904 outpatient children TRANS with signs of respiratory tract infection HP respiratory tract infection MESHD were admitted, and a total of 10102 throat swabs were collected. All the detection were performed to the throat swabs of patients, which include the epidemic statues, detection rate, duration of Flu A and B persistence in airway, and the positive rate of COVID-19 nucleic acid.Results: A total of 10102 throat swabs were obtained from children TRANS with respiratory symptoms, including 5450 (53.9%) male TRANS and 4652 (46.1%) female TRANS. 2899 (28.7%) cases were positive for Influenza A. There were 617 (6.1% ) cases of Influenza B . In group of Influenza A , the lowest positive rate was in the infants less than 1 year old (18.4%), and the highest in the group 12 year old (32.1%). During the period of high prevalence SERO of influenza A, there was a low level of infection of influenza B. The detection rate of each age group TRANS fluctuated from 3% to 10%. 73.7% of children TRANS's influenza A and B virus turned negative within 7 days, and very few children TRANS's respiratory influenza virus can last even more than 1 month. Among 35 throat swabs detected with qRT-PCR, 11 (31.4%) were positive for Flu A, and all children TRANS were negative for severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2).Conclusions: In the early stage of SARS-CoV-2 transmission, children TRANS in Wuhan were experiencing a high intensity of influenza A pandemic, and there was no the mixed infection of SARS-CoV-2 MESHD with influenza A. COVID-19 spread caught up the tail of influenza A pandemic. 

    Vitamin D deficiency MESHD as a predictor of poor prognosis in patients with acute respiratory failure MESHD respiratory failure HP due to COVID-19 

    Authors: Giovanna Elisiana Carpagnano; Valentina Di Lecce; Vitaliano Nicola Quaranta; Annapaola Zito; Enrico Buonamico; Elena Capozza; Alessandro Palumbo; Giuseppe Di Gioia; Vincenzo Nicola Valerio; Onofrio Resta

    doi:10.21203/rs.3.rs-41173/v1 Date: 2020-07-11 Source: ResearchSquare

    Purpose: H ypovitaminosis D MESHDis a highly spread condition correlated with increased risk of respiratory tract infections HP espiratory tract infections. MESHD Nowadays, the world is in the grip of the C oronavirus disease MESHD19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with a cute respiratory failure MESHD respiratory failure HP due to COVID-19 and to assess any correlations with disease severity and prognosis. Methods: In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with a cute respiratory failure MESHD respiratory failure HP due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020. Results: Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no h ypovitaminosis D, MESHD i nsufficiency, MESHD moderate d eficiency, and severe deficiency. MESHD No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency MESHDpatients had a 50% mortality probability, while those with vitamin D ≥10 had a 5% mortality risk (p=0.019). Conclusions: High prevalence SERO of h ypovitaminosis D MESHDwas found in COVID-19 patients with a cute respiratory failure, MESHD respiratory failure HP, treated in a RICU. Patients with severe vitamin D deficiency MESHDhad a significantly higher mortality risk. Severe vitamin D deficiency MESHDmay be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.

    Characterization of Microbial Co-infections MESHD infections in the Respiratory Tract HP of hospitalized COVID-19 patients

    Authors: Huanzi Zhong; Yanqun Wang; Zhun Shi; Lu Zhang; Huahui Ren; Weiqun He; Zhaoyong Zhang; Airu Zhu; Jingxian Zhao; Fei Xiao; Fangming Yang; Tianzhu Liang; Feng Ye; Bei Zhong; Shicong Ruan; Mian Gan; Jiahui Zhu; Fang Li; Fuqiang Li; Daxi Wang; Jiandong Li; Peidi Ren; Shida Zhu; Huanming Yang; Jian Wang; Karsten Kristiansen; Hein M Tun; Weijun Chen; Nanshan Zhong; Xun Xu; Yi-min Li; Junhua LI; Jincun Zhao

    doi:10.1101/2020.07.02.20143032 Date: 2020-07-05 Source: medRxiv

    Summary Background Severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has caused a global pandemic of Coronavirus disease MESHD 2019 (COVID-19). However, microbial composition of the respiratory tract and other infected tissues, as well as their possible pathogenic contributions to varying degrees of disease severity in COVID-19 patients remain unclear. Method Between January 27 and February 26, 2020, serial clinical specimens (sputum, nasal and throat swab, anal swab and feces) were collected from a cohort of hospitalized COVID-19 patients, including 8 mildly and 15 severely ill patients (requiring ICU admission and mechanical ventilation), in the Guangdong province, China. Total RNA was extracted and ultra-deep metatranscriptomic sequencing was performed in combination with laboratory diagnostic assays. Co-infection MESHD rates, the prevalence SERO and abundance of microbial communities in these COVID-19 patients were determined. Findings Notably, respiratory microbial co-infections MESHD were exclusively found in 84.6% of severely ill patients (11/13), among which viral and bacterial co-infections MESHD were detected by sequencing in 30.8% (4/13) and 69.2% (9/13) of the patients, respectively. In addition, for 23.1% (3/13) of the patients, bacterial co-infections MESHD with Burkholderia cepacia complex (BCC) and Staphylococcus epidermidis MESHD were also confirmed by bacterial culture. Further, a time-dependent, secondary infection of B. cenocepacia with expressions of multiple virulence genes in one severely ill patient was demonstrated, which might be the primary cause of his disease deterioration and death MESHD one month after ICU admission. Interpretation Our findings identified distinct patterns of co-infections MESHD with SARS-CoV-2 and various respiratory pathogenic microbes in hospitalized COVID-19 patients in relation to disease severity. Detection and tracking of BCC-associated nosocomial infections MESHD are recommended to improve the pre-emptive treatment regimen and reduce fatal outcomes of hospitalized patients infected with SARS-CoV-2. Funding National Science and Technology Major Project of China, National Major Project for Control and Prevention of Infectious Disease MESHD in China, the emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology and Guangdong province, Guangdong Provincial Key Laboratory of Genome Read and Write, Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, and Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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