Corpus overview


Overview

MeSH Disease

Human Phenotype

Pain (9)

Fever (6)

Fatigue (4)

Cough (4)

Hypertension (3)


Transmission

Seroprevalence
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    Epidemiology and clinical outcome of COVID-19: A multi-centre cross sectional study from Bangladesh

    Authors: Adnan Mannan; H.M. Hamidullah Mehedi; Naim Hasan Chy; Md. Omar Qayum; Farhana Akter; Abdur Rob; Prasun Biswas; Sanjida Hossain; Mustak Ibn Ayub; Nardin Rezk; Annarita Giliberti; Alessandra Renieri; Yiheng Chen; Sirui Zhou; Vincenzo Forgetta; J Brent Richards

    doi:10.1101/2020.09.09.20191114 Date: 2020-09-10 Source: medRxiv

    Objectives: To investigate SARS-CoV-2 associated epidemiology and clinical outcomes in Bangladesh to understand the course of COVID-19 pandemic and suggest prevention measures. Methods: A cross-sectional retrospective study was conducted among 1,021 RT-PCR confirmed but recovered COVID-19 cases from six participating hospitals in Bangladesh. Results: Of the total sample, 111 (10.9%) cases were asymptomatic TRANS while the number of symptomatic cases were 910 (89.1%). Higher prevalence SERO of COVID-19 persisted in the male TRANS population (75%) and for the 31-40 age group TRANS. More than 85% of the samples reported BCG vaccination mark. Common symptoms observed in our study samples were fever HP fever MESHD (72.4%), cough HP (55.9%), loss of taste MESHD (40.7%) and body ache MESHD (40%); whereas for the biochemical parameters, Neutrophil (46.4%), D-dimer (46.1%), Ferritin (37.9%) and SGPT (36.8%) levels were found elevated. Post-COVID complications including pain HP pain MESHD (31.8%), loss of concentration (24.4%) and anxiety HP anxiety MESHD or depression (23.1%) were found significantly prevalent. Conclusion: Our study has shown that adult TRANS males TRANS aged TRANS between 31-40 in Bangladesh are more vulnerable to being infected with COVID-19. With an indication for the rising trend of the asymptomatic TRANS cases, deployment of interventions to curb further community spread is necessary to avoid the grave outcomes of COVID-19 in Bangladesh.

    Seroprevalence SERO and correlates of SARS-CoV-2 neutralizing antibodies SERO: Results from a population-based study in Bonn, Germany

    Authors: N. Ahmad Aziz; Victor M Corman; Antje K.C. Echterhoff; Anja Richter; Antonio Schmandke; Marie Luisa Schmidt; Thomas H. Schmidt; Folgerdiena M De Vries; Christian Drosten; Monique M.B. Breteler; Charles E Murry; Michel C Nussenzweig; Anthony P West; Pamela J Bjorkman; Tong Jin; Chengmin Shi; Zhenglin Du; Yadong Zhang; Chuandong Liu; Rujiao Li; Jingyao Zeng; Lili Hao; Shuai Jiang; Hua Chen; Dali Han; Jingfa Xiao; Zhang Zhang; Wenming Zhao; Yongbiao Xue; Yiming Bao; Valerie Mioulet; Joseph Newman; Amin S Asfor; Alison Burman; Sylvia Crossley; John Hammond; Elma Tchilian; Bryan Charleston; Dalan Bailey; Tobias J Tuthill; Simon Graham; Tomas Malinauskas; Jiandong Huo; Julia Tree; Karen Buttigieg; Ray Owens; Miles Carroll; Rod Daniels; John McCauley; Kuan-Ying A Huang; Mark Howarth; Alain Townsend

    doi:10.1101/2020.08.24.20181206 Date: 2020-08-29 Source: medRxiv

    Background Accurate estimates of SARS-CoV-2 seroprevalence SERO are crucial for the implementation of effective public health measures, but are currently largely lacking in regions with low infection rates. This is further complicated by inadequate test performance SERO of many widely used serological assays SERO. We therefore aimed to assess SARS-CoV-2 seroprevalence SERO in a region with low COVID-19 burden, especially focusing on neutralizing antibodies SERO that presumably constitute a major component of acquired immunity. Methods We invited all individuals who were enrolled in the Rhineland Study, an ongoing community-based prospective cohort study in people aged TRANS 30 years and above in the city of Bonn, Germany (N=5427). Between April 24th and June 30th, 2020, 4771 (88%) of these individuals participated in the serosurvey. Anti-SARS-CoV-2 IgG levels were measured using an ELISA assay SERO, and all positive or borderline results were subsequently examined through both a recombinant immunofluorescent assay and a plaque reduction neutralisation test (PRNT). Findings Seroprevalence SERO was 0.97% (95% CI: 0.72-1.30) by ELISA SERO and 0.36% (95% CI: 0.21-0.61) by PRNT, and did not vary with either age TRANS or sex. All PRNT+ individuals reported having experienced at least one symptom (odds ratio (OR) of PRNT+ for each additional symptom: 1.12 (95% CI: 1.04-1.21)). Apart from living in a household with a SARS-CoV-2 confirmed or suspected person, a recent history of reduced taste or smell, fever HP, chills HP/ hot flashes HP, pain HP while breathing, pain HP in arms/legs, as well as muscle pain HP and weakness were significantly associated with the presence of neutralizing antibodies SERO in those with mild to moderate infection (ORs 3.44 to 9.97, all p<0.018). Interpretation Our findings indicate a relatively low SARS-CoV-2 seroprevalence SERO in Bonn, Germany (until June 30th, 2020), with neutralizing antibodies SERO detectable in only one third of those with a positive immunoassay SERO result, implying that almost the entire population in this region remains susceptible to SARS-CoV-2 infection.

    Prevalence SERO and Correlates of Fatigue HP and Its Association with Quality of Life Among Clinically Stable Older Psychiatric Patients During the COVID-19 Outbreak: A Cross-Sectional Study

    Authors: Siyun Zou; Zi-Han Liu; Xiaona Yan; Huan Wang; Yulong Li; Xiuying Xu; Xiangdong Du; Lan Zhang; Qinge Zhang; Todd Jackson; Gabor S. Ungvari; Yu-Tao Xiang

    doi:10.21203/rs.3.rs-63565/v1 Date: 2020-08-21 Source: ResearchSquare

    Background: The pattern of fatigue HP fatigue MESHD in older psychiatric MESHD patients during the COVID-19 outbreak was unknown. This study examined the prevalence SERO of fatigue HP fatigue MESHD and its association with quality of life (QOL) in clinically stable older patients with psychiatric disorders MESHD during the COVID-19 outbreak. Methods: This is a multicenter, cross-sectional study. Fatigue HP, depression MESHD, pain HP pain MESHD, insomnia HP insomnia MESHD symptoms, and QOL were assessed with standardized instruments.  Results: A total of 1,063 patients were recruited. The prevalence SERO of fatigue HP fatigue MESHD was 47.1% (95%CI: 44.1% - 50.1%). Analysis of covariance revealed that QOL was significantly lower in patients with fatigue HP fatigue MESHD compared to those without (P=0.011). Multiple logistic regression analysis revealed that more severe depression MESHD (OR=1.15, P<0.001), insomnia HP insomnia MESHD symptoms (OR=1.08, P<0.001) and pain HP pain MESHD (OR=1.43, P<0.001) were significantly associated with fatigue HP fatigue MESHD.Conclusions: Fatigue HP was common among clinically stable older patients with psychiatric disorders MESHD during the COVID-19 outbreak. Considering its negative impact on QOL, regular assessment of fatigue HP fatigue MESHD and appropriate treatment warrant attention in this subpopulation.

    Prevalence SERO, Pattern and Impact of Self Medication of Anti-infective Agents During COVID-19 Outbreak in Dhaka City

    Authors: Morshed Nasir; Khandaker Abu Talha; ASM Salauddin Chowdhury; Tahmina Zahan; Rawshan Ara Perveen

    doi:10.21203/rs.3.rs-57011/v1 Date: 2020-08-10 Source: ResearchSquare

    Background: The outbreak of coronavirus disease-2019 is putting a massive strain on vulnerable healthcare system in low and middle-income countries like Bangladesh. Inequitable access to healthcare is further widened by the socio-economic gap and sense of insecurity during this pandemic. Self-medication is a common practice in Bangladesh as it provides a low-cost alternative for people, which involves inappropriate and injudicious use of medicines to treat self-recognized symptoms by the people. During the outbreak of COVID-19 in Dhaka city, the tendency of taking medicines by own decision was thought to be increased alarmingly due to unusual distress, caused by high self-awareness of their health and buying capacity of medication. Objectives: To observe the prevalence SERO, pattern, sources and impact of self-medication practice among the respondents with high socio-economic standings and education. Setting: Citizens living in Dhaka city, Bangladesh during COVID-19 outbreak from April 2020 to May 2020. Method: Cross sectional online survey conducted on 626 citizens without having background of medical knowledge or related to any healthcare services (doctors, nurses, pharmacist, medical students) by structured questionnaires during COVID-19 outbreak. Outcome measures: Frequency of self-medication, commonly used antimicrobial agents, symptoms causing self-medication, sources of inspiration, relation with COVID-19 test results, economic burden involved in self-medication during outbreak. Results: The prevalence SERO of self-medication amid the outbreak of COVID-19 was 88.33% and only 179 (28.59%) took medication with doctors’ advice and remaining 447 (71.40%) respondents took the drugs as “self-medication” by other sources. The most frequently used anti-infective drugs during the outbreak were ivermectine (77.15%), azithromycin (54.15%), doxycycline (40.25%). The common symptoms were fever HP fever MESHD, throat pain HP, dry-cough MESHD cough HP and total 105 (16.77%) respondents took medications without having any symptoms. Almost 355 (85.33%) had taken medication without doing any test for COVID-19. The causes of self-medication as news of spread, effects and remedies in media channels, internet; mental stress of lockdown and isolation, insecurity and panic about scarcity of drug and healthcare support. Conclusion: High risks of developing antibiotic resistance, adverse drug reactions and financial loss was predictable with absence of strict regulatory enforcement to protect people and proper utilization resources during COVID-19 outbreak in Dhaka city.

    Psychosocial factors associated with postpartum psychological distress during the Covid-19 pandemic: a cross-sectional study.

    Authors: Luca Ostacoli; Stefano Cosma; Federica Bevilacqua; Paola Berchialla; Marialuisa Bovetti; Andrea Roberto Carosso; Francesca Malandrone; Sara Carletto; Chiara Benedetto

    doi:10.21203/rs.3.rs-54728/v1 Date: 2020-08-06 Source: ResearchSquare

    Background Trauma MESHD, natural and man-made catastrophic events can be predictors of postpartum psychological distress. In a public health response due to coronavirus disease MESHD 2019 outbreak, the Italian government imposed a lockdown from March 9 to May 3. This extraordinary situation may have been challenging for maternal psychological health. The aim of this study was to investigate the prevalence SERO of depressive MESHD and post- traumatic stress symptoms MESHD in women giving birth during the Covid-19 pandemic and its associations with quarantine measures, obstetrical factors, and relational attachment style. Methods Women who gave birth in a high-volume obstetric/gynaecological medical centre located in an epidemic area during the Covid-19 pandemic (March 8 to June 15) were asked to complete an online survey about their childbirth experience and the perceived effect of the pandemic. The Edinburgh Postnatal Depression MESHD Scale (EPDS), the Impact of Event Scale-Revised (IES-R), and the Relationship Questionnaire (RQ) were administered to assess levels of postpartum depressive MESHD and post- traumatic stress symptoms MESHD (PTSS) and relational style of attachment, respectively. Multivariate analysis was applied to identify associations between quarantine measures, childbirth experience, attachment style, and EPDS and IES-R scores.Results The survey was completed by 163 women (response rate 60.8%). The prevalence SERO of depressive symptoms MESHD was 44.2% (EPDS cut-off score ≥11) and the PTSS rate was 42.9% (IES-R cut-off score ≥24). Dismissive and fearful avoidant attachment styles were significantly associated with the risk of depression MESHD and PTSS, respectively. Perceived pain HP pain MESHD during delivery was a risk factor for postpartum depression MESHD. Perceived support provided by healthcare staff was a protective factor against depression MESHD and PTSS. Another protective factor against PTSS was quiet on the ward due to the absence of hospital visitors. Conclusion This study reports a high prevalence SERO of postpartum depressive MESHD and PTSS in women who delivered during the Covid-19 pandemic. Postnatal psychological distress seemed to be associated more with the prenatal experience and other individual factors than with the pandemic hospital restrictions. Early detection during pregnancy of an insecure attachment style is fundamental to provide targeted preventive and therapeutic psychological interventions.

    The influence of comorbidity on the severity of COVID-19 disease: A systematic review and analysis

    Authors: Nazar Zaki; Elfadil Abdalla Mohamed; Sahar Ibrahim; Gulfaraz Khan

    doi:10.21203/rs.3.rs-37127/v2 Date: 2020-06-20 Source: ResearchSquare

    Background: A novel form of coronavirus disease MESHD (SARS-CoV-2) has spread rapidly across the world. What risk factors influence the severity of the disease is of considerable importance.Aim: This research offers a systematic review and meta-analysis of the correlation between common clinical conditions and comorbidities and the severity of COVID-19.Methodology: Two independent researchers searched Europe PMC, Google Scholar, and PubMed databases for articles related to influence comorbidities have on the progress of the disease. A search engine was also created to screen a further 59,000 articles in COVID-19 Open Research Dataset (CORD-19). Random-effects modeling was used to pool 95% confidence intervals (CIs) and odds ratios (ORs). The significance of all comorbidities and clinical conditions to the severity of the disease was evaluated by employing machine-learning techniques. Publication bias was assessed by using funnel-plots and Egger’s test. Heterogeneity was tested using I2.Results: The meta-analysis incorporated 12 studies spanning 4,101 confirmed COVID-19 patients who were admitted to Chinese hospitals. The prevalence SERO of the most commonly associated co-morbidities and their corresponding odds ratio for disease severity were as follows: coronary heart disease MESHD (OR 2.97 [CI: 1.99-4.45], p < 0.0001), cancer MESHD (OR 2.65 [CI: 1.12-6.29], p < 0.03), cardiovascular disease MESHD (OR 2.89 [CI: 1.90-4.40], p < 0.0001), COPD MESHD (OR 3.24 [CI: 1.66-6.32], p = 0.0), and kidney disease MESHD (OR 2.2.4 [CI: 1.01-4.99], p = 0.05) with low or moderate level of heterogeneity. The most frequently exhibited clinical symptoms were fever HP fever MESHD (OR 1.37 [CI: 1.01-1.86], p = 0.04), myalgia HP myalgia MESHD/ fatigue HP fatigue MESHD (OR 1.31 [CI: 1.11-1.55], p = 0.0018), and dyspnea HP dyspnea MESHD (OR 3.61, [CI: 2.57-5.06], p = <0.0001). No significant associations between disease severity and liver disease MESHD, smoking habits, and other clinical conditions, such as a cough HP, respiratory/ARDS, diarrhea HP diarrhea MESHD or chest tightness HP chest tightness MESHD/ pain HP pain MESHD were found. The meta-analysis also revealed that the incubation period TRANS was positively associated with disease severity. Conclusion: Existing comorbidities, including COPD, cardiovascular disease MESHD, and coronary heart disease MESHD, increase the severity of COVID-19. Some studies found a statistically significant association between comorbidities such as diabetes MESHD and hypertension HP hypertension MESHD and disease severity. However, these studies may be biased due to substantial heterogeneity. 

    The influence of comorbidity on the severity of COVID-19 disease: A scoping review and meta-analysis

    Authors: Nazar Zaki; Elfadil Abdalla Mohamed; Sahar Ibrahim; Gulfaraz Khan

    doi:10.21203/rs.3.rs-37127/v3 Date: 2020-06-20 Source: ResearchSquare

    Background: A novel form of coronavirus disease MESHD (SARS-CoV-2) has spread rapidly across the world. What risk factors influence the severity of the disease is of considerable importance. Objectives: This research offers a systematic review and meta-analysis of the correlation between common clinical conditions and comorbidities and the severity of COVID-19. Methodology: Two independent researchers searched Europe PMC, Google Scholar, and PubMed databases for articles related to influence comorbidities have on the progress of the disease. A search engine was also created to screen a further 59,000 articles in COVID-19 Open Research Dataset (CORD-19). Random-effects modeling was used to pool 95% confidence intervals (CIs) and odds ratios (ORs). The significance of all comorbidities and clinical conditions to the severity of the disease was evaluated by employing machine-learning techniques. Publication bias was assessed by using funnel-plots and Egger’s-test. Heterogeneity was tested using I2. Results: The meta-analysis incorporated 12 studies spanning 4,101 confirmed COVID-19 patients who were admitted to Chinese hospitals. The prevalence SERO of the most commonly associated co-morbidities and their corresponding odds ratio for disease severity were as follows: coronary heart disease (OR 2.97 [CI: 1.99-4.45], p < 0.0001), cancer (OR 2.65 [CI: 1.12-6.29], p < 0.03), cardiovascular disease (OR 2.89 [CI: 1.90-4.40], p < 0.0001), COPD (OR 3.24 [CI: 1.66-6.32], p = 0.0), and kidney disease (OR 2.2.4 [CI: 1.01-4.99], p = 0.05) with low or moderate level of heterogeneity. The most frequently exhibited clinical symptoms recorded during the course of admission were fever HP (OR 1.37 [CI: 1.01-1.86], p = 0.04), myalgia HP/ fatigue HP (OR 1.31 [CI: 1.11-1.55], p = 0.0018), and dyspnea HP (OR 3.61, [CI: 2.57-5.06], p = <0.0001). No significant associations between disease severity and liver disease, smoking habits, and other clinical conditions, such as a cough HP, respiratory/ARDS, diarrhea HP or chest tightness HP/ pain HP were found. The meta-analysis also revealed that the incubation period TRANS was positively associated with disease severity. Conclusion: Existing comorbidities, including COPD, cardiovascular disease, and coronary heart disease, increase the severity of COVID-19. Some studies found a statistically significant association between comorbidities such as diabetes and hypertension HP and disease severity. However, these studies may be biased due to substantial heterogeneity.

    COVID-19-like symptoms and their relation to SARS-CoV-2 epidemic in children TRANS and adults TRANS of an Italian birth cohort

    Authors: Maja Popovic; Chiara Moccia; Elena Isaevska; Giovenale Moirano; Costanza Pizzi; Daniela Zugna; Franca Rusconi; Franco Merletti; Milena Maule; Lorenzo Richiardi

    doi:10.21203/rs.3.rs-34027/v1 Date: 2020-06-08 Source: ResearchSquare

    Background Emerging COVID-19 pandemic caused extensive lockdowns in a number of countries, but yet unknown number of cases positive to SARS-CoV-2 escapes surveillance systems. Methods Mothers participating in an Italian NINFEA birth cohort were invited to complete an online questionnaire on COVID-19-like symptoms in the household. We estimated the population prevalence SERO of COVID-19-like symptoms in children TRANS and adults TRANS, assessed their geographical correlation with the cumulative number of COVID-19 cases by province, analysed their clustering within families, and estimated their sensitivity SERO, positive (PPV) and negative predictive values SERO (NPV) for COVID-19 diagnosis in individuals tested for SARS-CoV-2.Results Information was collected on 3184 households, 6133 adults TRANS, and 5751 children TRANS. There was a strong geographical correlation between the population cumulative incidence of COVID-19 and the prevalence SERO of muscle pain MESHD pain HP, fatigue HP fatigue MESHD, low-grade fever HP fever MESHD, and breathing difficulties in adults TRANS (Spearman’s rho ≥0.70). Having at least one family member TRANS with a COVID-19 diagnosis, compared with none tested for SARS-CoV-2, was associated with an increased prevalence SERO ratio of almost all COVID-19-like symptoms in adults TRANS, and only of low-grade fever HP (37-37.5oC; prevalence SERO ratio 5.27; 95% confidence intervals: 2.37 to 11.74) and anosmia HP anosmia MESHD/dysgeusia in children TRANS. Among adults TRANS with COVID-19, fatigue HP fatigue MESHD, muscle pain MESHD pain HP, and fever HP fever MESHD had a sensitivity SERO ≥70%. In individuals tested for SARS-CoV-2, with a 16.6% prevalence SERO of COVID-19, breathing difficulties and nausea/vomiting HP nausea/vomiting MESHD vomiting MESHD had the highest PPVs, with point estimates close to 60%, and with NPVs close to 90%. Among tested Piedmont residents, with a COVID-19 prevalence SERO of 18.5%, breathing difficulties and anosmia HP anosmia MESHD/disguesia reached PPVs above 80%.Conclusion Geographical prevalence SERO of COVID-19-like symptoms in adults TRANS may inform on local disease clusters, while certain symptoms in family members TRANS of confirmed COVID-19 cases could help identification of the intra-familial spread of the virus and its further propagation in the community. Low-grade fever HP is frequent in children TRANS with at least one household member with COVID-19 and possibly indicates child TRANS infection.  

    Clinical symptoms and psychological changes of patients with COVID-19 in Jiangxi Province

    Authors: Jing Zhou; Xin-Ping Xu; Fei Xu; Yi Shao; Mei-Hong Zou; Jing-Jing Yu; Fen Liu; Wei Zuo; Si-Guang Xie; Cong-Yang Zhou; Wei Zhang

    doi:10.21203/rs.3.rs-18080/v1 Date: 2020-03-18 Source: ResearchSquare

    Objective The purpose of this study was to determine the prevalence SERO and differences in etiology, clinical manifestations, and psychological activity of coronavirus disease-19 (COVID-19) among patients. Results We recruited 90 subjects, 30 were healthy controls, 30 were patients with moderate infection MESHD, and 30 were patients with severe/ critical infections MESHD. No significant differences were noted in the sex ratio, mean age TRANS, body mass index, or blood SERO type; however, the history of exposure of the patients with COVID-19 compared with healthy controls was noteworthy. The erythrocyte sedimentation rate, as well as the levels of C-reactive protein and serum SERO amyloid A (SAA) were all increased. In terms of mental health, there were significant differences in the worry scores between severely and moderately infected MESHD patients and healthy controls. There was a significant difference in depression MESHD scores between patients with moderate infection MESHD and healthy hypertension HP hypertension MESHD, and there was also a significant difference in dream worry scores. Analysis of the Mini-Mental State Examination scores showed that for patients with moderate infection MESHD, the depression MESHD score was moderately and positively correlated with the dream anxiety HP anxiety MESHD score. For patients with severe infection HP infection MESHD, the anxiety HP anxiety MESHD score was positively correlated with the dream anxiety HP anxiety MESHD score, and the depression MESHD score was moderately and positively correlated with the dream anxiety HP anxiety MESHD score. Conclusion Patients with severe infection HP infection MESHD showed increased pain HP pain MESHD and sputum in the pharyngeal area compared with patients with moderate infection MESHD. Patients with blood SERO type A may be more susceptible to COVID-19, and lymphopenia HP lymphopenia MESHD may indicate worsening of COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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