Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

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Seroprevalence
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    High prevalence SERO of putative invasive pulmonary aspergillosis HP invasive pulmonary aspergillosis MESHD in critically ill COVID-19 patients

    Authors: Alexandre Alanio; Sarah Delliere; Sofiane Fodil; Stephane Bretagne; Bruno Megarbane

    doi:10.1101/2020.04.21.20064915 Date: 2020-04-24 Source: medRxiv

    We are currently facing a frightening increase in COVID-19 patients admitted to the ICU. Aiming at screening for fungal secondary pneumonia HP pneumonia MESHD, we collected the data of our first 27 ICU patients, who underwent bronchoalveolar lavage or bronchial aspirates. We classified the patients based on the recently published study on invasive aspergillosis MESHD in influenza patients in your journal (Schauwvlinghe et al., 2018.) and found 33% of our COVID-19 patients with putative invasive pulmonary aspergillosis HP invasive pulmonary aspergillosis MESHD. Observing such a high prevalence SERO in COVID-infected MESHD patients was somehow unexpected since the 30% prevalence SERO of invasive aspergillosis MESHD in influenza patients has been attributed to the action of oseltamivir on anti-Aspergillus immunity. Almost all critically ill COVID-19 patients develop ARDS MESHD and are likely to receive high-dose steroids or immunomodulatory therapies to prevent worsening as suggested by reports from China. In the COVID-19 patients with putative invasive aspergillosis MESHD, antifungal prophylactic therapy may be questioned to avoid increased lung inflammation MESHD that may compromise the outcome. This issue remains to be addressed in future clinical trials. We are strongly convinced that testing deep lung specimens for Aspergillus in severe COVID-19 patients should be recommended. This message is major, given the high mortality rate of COVID-19 patients in the ICU.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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