Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (2)

Fever (2)

Asthenia (2)

Anosmia (1)

Cough (1)


Transmission

Seroprevalence
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    IgG seroprevalence SERO against SARS-CoV-2 in a cohort of 449 non-hospitalized, high-risk exposure individuals.

    Authors: Patricia Torres Martínez; Paula Diaque García; María Rubio Salas; Raquel Rodríguez Sánchez; Felipe García; Miguel Ángel Llamas; Paula Saz-Leal; CArlos del Fresno

    doi:10.21203/rs.3.rs-53747/v1 Date: 2020-08-04 Source: ResearchSquare

    COVID-19 pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection MESHD. Mobility restrictions but also the requirement of a medical prescription to gain access to serological testing SERO for COVID-19 were included among the measures. Under this scenario, between April 15th to June 15th, 2020, we performed a seroprevalence SERO observational study including 449 individuals that fulfill prescription requirements: manifesting COVID-19 compatible symptoms, being in contact with a COVID-19 confirmed case TRANS or belonging to essential occupations including healthcare workers, firefighters or public safety personnel such as police. Importantly, none of the participants was hospitalized. Altogether, we studied this specific, non-commonly addressed cohort for SARS-CoV-2 seroprevalence SERO, uncovering intrinsic features of great demographic interest. The overall rate of IgG seropositivity was 33.69% (95% CI: 29.27 – 38.21). This seroprevalence SERO was comparable between different occupations performed by the participants. However, contacts with confirmed cases TRANS associated positively with IgG+ results, with stronger correlation if being a household member. The number of symptoms also correlated positively with IgG+ prevalence SERO. Ageusia/anosmia, pneumonia MESHD anosmia HP, pneumonia HP and cutaneous manifestations were the top-three symptoms that most strongly associated with IgG+ seroprevalence SERO. However, while pneumonia HP pneumonia MESHD and cutaneous manifestations were barely present in our cohort, fever HP fever MESHD, ageusia/anosmia MESHD anosmia HP and asthenia HP were the most frequently symptoms described within IgG+ subjects. Therefore, our data illustrate how specific cohorts display heterogeneous characteristics that should be taken into account when identifying population seroprevalence SERO against SARS-CoV-2 and key defining symptoms for COVID-19.

    Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study

    Authors: Roberto de la Rica; Marcio Borges; Maria Aranda; Alberto del Castillo; Antonia Socias; Antoni Payeras; Gemma Rialp; Lorenzo Socias; Lluis Masmiquel; Marta Gonzalez-Freire

    doi:10.1101/2020.05.07.20094987 Date: 2020-05-11 Source: medRxiv

    OBJECTIVE To describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior hospitalization, in one of the main hospitals in The Balearic Islands health care system. DESIGN Retrospective observational study SETTING Son Llatzer University Hospital in Palma de Mallorca MESHD (Spain) PARTICIPANTS Among a cohort of 52 hospitalized patients as of 31 March 2020, 48 with complete demographic information and severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) positive test, were analyzed. Data were collected between March 15th, 2020, and March 31th 2020, inclusive of these dates. MAIN OUTCOMES Clinical, vital signs and routine laboratory outcomes at the time of hospitalization, including symptoms reported prior to hospitalization. Demographics and baseline comorbidities were also collected. Mortality was reported at the end of the study. RESULTS 48 patients (27 non-ICU and 21 ICU) resident in Mallorca, Spain (mean age TRANS, 66 years, [range, 33-88 years]; 67% males TRANS) with positive SARS-CoV-2 infection MESHD were analyzed. There were no differences in age TRANS or sex among groups (p >.05). Initial symptoms included fever HP fever MESHD (100%), coughing HP (85%), dyspnea HP dyspnea MESHD (76%), diarrhea HP diarrhea MESHD (42%) and asthenia HP asthenia MESHD (21%). The majority of patients in this case series were hospitalized because of low SpO2 (SpO2 below 90%) and presentation of bilateral pneumonia MESHD pneumonia HP (94%) at triage. ICU patients had a higher prevalence SERO of dyspnea HP dyspnea MESHD compared to non-ICU patients (95% vs 61%, p = .022). Acute respiratory syndrome MESHD ( ARDS MESHD) was presented in 100% of the ICU-patients. All the patients included in the study required oxygen therapy. ICU-patients had lymphopenia HP lymphopenia MESHD as well as hypoalbuminemia HP hypoalbuminemia MESHD. Inflammatory markers such as lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < .001).Lower albumin levels were associated with poor prognosis measured as longer hospital length (r= -0.472, p

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MeSH Disease
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Transmission
Seroprevalence


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