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Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Bacteremia HP Bacteremia MESHD and Blood SERO Culture Utilization During COVID-19 Surge in New York City

    Authors: Jorge Sepulveda; Lars F Westblade; Susan Whittier; Michael Joseph Satlin; William Greendyke; Justin G Aaron; Jason E. Zucker; Donald Dietz; Magdalena E Sobieszczyk; Justin J Choi; Dakai Liu; Kelvin Espinal; Sarah Russell; Dennis Camp; Charles Connelly; Daniel A. Green

    doi:10.1101/2020.05.05.20080044 Date: 2020-05-06 Source: medRxiv

    A surge of patients with coronavirus disease MESHD 2019 (COVID-19) presenting to New York City hospitals in March 2020 led to a sharp increase in the utilization of blood SERO cultures, which overwhelmed the capacity of automated blood SERO culture instruments. We sought to evaluate the utilization and diagnostic yield of blood SERO cultures during the COVID-19 pandemic to determine prevalence SERO and common etiologies of bacteremia HP bacteremia MESHD, and to inform a diagnostic approach to relieve blood SERO culture overutilization. We performed a retrospective cohort analysis of 88,201 blood SERO cultures from 28,011 patients at a multicenter network of hospitals within New York City to evaluate order volume, positivity rate, time to positivity, and etiologies of positive cultures in COVID-19. Ordering volume increased by 34.8% in the second half of March 2020 compared to the first half of the month. The rate of bacteremia HP bacteremia MESHD was significantly lower among COVID-19 patients (3.8%) than COVID-19 negative patients (8.0%) and those not tested (7.1%), p < 0.001. COVID-19 patients had a high proportion of organisms reflective of commensal skin microbiota, reducing the bacteremia HP bacteremia MESHD rate to 1.6% when excluded. More than 98% of all positive cultures were detected within 4 days of incubation. Bloodstream infections are very rare for COVID-19 patients, which supports the judicious use of blood SERO cultures in the absence of compelling evidence for bacterial co-infection MESHD. Clear communication with ordering providers is necessary to prevent overutilization of blood SERO cultures during COVID-19 surges, and laboratories should consider shortening the incubation period TRANS from 5 days to 4 days to free additional capacity.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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