Corpus overview


MeSH Disease

Human Phenotype


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    Prevalence SERO and Correlates of Fatigue HP and Its Association with Quality of Life Among Clinically Stable Older Psychiatric Patients During the COVID-19 Outbreak: A Cross-Sectional Study

    Authors: Siyun Zou; Zi-Han Liu; Xiaona Yan; Huan Wang; Yulong Li; Xiuying Xu; Xiangdong Du; Lan Zhang; Qinge Zhang; Todd Jackson; Gabor S. Ungvari; Yu-Tao Xiang

    doi:10.21203/ Date: 2020-08-21 Source: ResearchSquare

    Background: The pattern of fatigue HP fatigue MESHD in older psychiatric MESHD patients during the COVID-19 outbreak was unknown. This study examined the prevalence SERO of fatigue HP fatigue MESHD and its association with quality of life (QOL) in clinically stable older patients with psychiatric disorders MESHD during the COVID-19 outbreak. Methods: This is a multicenter, cross-sectional study. Fatigue HP, depression MESHD, pain HP pain MESHD, insomnia HP insomnia MESHD symptoms, and QOL were assessed with standardized instruments.  Results: A total of 1,063 patients were recruited. The prevalence SERO of fatigue HP fatigue MESHD was 47.1% (95%CI: 44.1% - 50.1%). Analysis of covariance revealed that QOL was significantly lower in patients with fatigue HP fatigue MESHD compared to those without (P=0.011). Multiple logistic regression analysis revealed that more severe depression MESHD (OR=1.15, P<0.001), insomnia HP insomnia MESHD symptoms (OR=1.08, P<0.001) and pain HP pain MESHD (OR=1.43, P<0.001) were significantly associated with fatigue HP fatigue MESHD.Conclusions: Fatigue HP was common among clinically stable older patients with psychiatric disorders MESHD during the COVID-19 outbreak. Considering its negative impact on QOL, regular assessment of fatigue HP fatigue MESHD and appropriate treatment warrant attention in this subpopulation.

    Associations of exercise and social support with mental health during quarantine and social-distancing measures during the COVID-19 pandemic: A cross-sectional survey in Germany

    Authors: Leonie Louisa Bauer; Britta Seiffer; Clara Deinhart; Beatrice Atrott; Gorden Sudeck; Martin Hautzinger; Inka Rösel; Sebastian Wolf

    doi:10.1101/2020.07.01.20144105 Date: 2020-07-02 Source: medRxiv

    Introduction: Social distancing and quarantine measures applied during the COVID-19 pandemic might result in mental health problems. In this cross-sectional study we examined if perceived social support, exercise in minutes per week and change in exercise are protective factors regarding symptoms of depression MESHD, anxiety HP anxiety MESHD, and sleeping disorders MESHD. Method: In April 2020, n = 4271 German adults TRANS completed an online survey including mental health questionnaires regarding depression MESHD (PHQ-D), anxiety HP anxiety MESHD (PHQ-D) and sleep (PSQI), as well as questionnaires related to protective factors such as exercise (BSA-F), physical activity-related health competence (PAHCO) and social support (F-SozU). Results: Complete case analysis (n = 3700; mean age TRANS 33.13 {+/-} 11.73 years, 78.6 % females TRANS) resulted in elevated prevalence SERO of depressive disorder MESHD (31.4%), panic disorder MESHD (5.7%) and other anxiety HP anxiety MESHD disorders (7.4%). 58.3% reported symptoms of insomnia HP insomnia MESHD. Three separate models of multiple regression were conducted. Perceived social support was associated with lower values of anxiety HP anxiety MESHD (beta = -0.10; t(19) = -6.46; p >0.001), lower values of depressive symptoms MESHD (beta = -0.22; t(19) = -15.71; p < .001) and lower values of sleeping disorder MESHD symptoms (beta = -0.15; t(19) = -9.55; p < .001). Change towards less exercise compared to the time before Covid-19 was associated with and higher values of anxiety HP anxiety MESHD (beta = -0.05; t(19) = -2.85; p= .004), higher values of depressive symptoms MESHD (beta = -0.08; t(19) = -5.69; p < .001), and higher values of sleeping disorder MESHD symptoms (beta = -0.07; t(19) = -4.54; p < .000). Post-hoc analysis (ANOVAs) revealed that a change towards less exercise was significantly associated with more depressive MESHD, anxiety HP anxiety MESHD and sleeping disorder symptoms whereas a positive change was not. No significant association was found for exercise in minutes per week for all outcomes. Conclusion: The COVID-19 pandemic seems to have a negative impact on mental health in the German population. Social Support and a stable amount of exercise might attenuate these negative mental health consequences. Ongoing monitoring of the impact of the pandemic on mental health and possible protective factors is needed in order to create a basis for the development of appropriate prevention and intervention measures.

    Efficacy of an online cognitive behavioral therapy program developed for healthcare workers during the COVID-19 pandemic: The REduction of STress MESHD ( REST MESHD) study protocol for a randomized controlled trial

    Authors: Luisa Weiner; Fabrice Berna; Nathalie Nourry; François Severac; Pierre Vidailhet; Amaury C. Mengin

    doi:10.21203/ Date: 2020-06-22 Source: ResearchSquare

    Background: The acknowledgement of the mental health toll of the COVID-19 epidemic in healthcare workers has increased considerably as the disease evolved into a pandemic status. Indeed, high prevalence SERO rates of depression MESHD, sleep disorders MESHD and post- traumatic stress disorder MESHD ( PTSD MESHD) have been reported in Chinese healthcare workers during the epidemic peak. Symptoms of psychological distress MESHD are expected to be long-lasting and have a systemic impact on healthcare systems, warranting the need for evidence-based psychological treatments aiming at relieving immediate stress and preventing the onset of psychological disorders MESHD in this population. In the current COVID-19 context, internet-based interventions have the potential to circumvent the pitfalls of face-to-face formats, and provide the flexibility required to facilitate accessibility to healthcare workers. Online cognitive behavioral therapy (CBT) in particular has proved to be effective in treating and preventing a number of stress-related disorders in populations other than healthcare workers. The aim of our randomized controlled trial study protocol is to evaluate the efficacy of the ‘My Health too’ CBT program – a program we have developed for healthcare workers facing the pandemic -- on immediate perceived stress, and on the emergence of psychiatric disorders MESHD at 3- and 6-month follow-up compared to an active control group (i.e., bibliotherapy). Methods: Powered for non-inferiority testing, this six-site open trial involves the random assignment of 120 healthcare workers with stress levels >16 on the Perceived Stress Scale (PSS-10) to either the 7-session online CBT program or bibliotherapy. The primary outcome is the decrease of PSS-10 scores. Secondary outcomes include depression MESHD, insomnia HP insomnia MESHD, and PTSD MESHD symptoms, self-reported resilience and rumination, as well as credibility and satisfaction. Assessments are scheduled at pretreatment, mid-treatment (at 4 weeks), end of active treatment (at 8 weeks) and at 3-month and 6-month follow-up. Discussion: This is the first study assessing the efficacy and the acceptability of a brief online CBT program specifically developed for healthcare workers. Given the potential short- and long-term consequences of the COVID-19 pandemic on healthcare workers’ mental health, but also on healthcare systems, our findings can significantly impact clinical practice and management of the ongoing, and probably long-lasting, health crisis. Trial registration: NCT04362358, registered April 24, 2020.

    Dimensions and modulators of behavioural and mental-health changes during the Covid-19 pandemic: an N=343,017 study

    Authors: Adam Hampshire; Peter Hellyer; Eyal Soreq; William Trender; Mitul A Mehta; Konstantinos Ioannidis; Jon E Grant; Samuel R Chamberlain

    doi:10.1101/2020.06.18.20134635 Date: 2020-06-20 Source: medRxiv

    BACKGROUND The effects of the Covid-19 pandemic on mental health remain unclear. To mitigate the risks and capitalise on opportunities for positive change, we must understand how the impact has been mediated by sociodemographics, mental disorders MESHD disorders, personality HP traits, life circumstances and the coping measures people choose to take. METHODS Data were collected from 376,987 members of the general public, predominantly in the UK, between late December 2019 and May 2020. Interaction models examined differences in sociodemographic distributions of mood and anxiety HP anxiety MESHD for 233,268 people in January vs. 109,749 in May. Factor analysis of a comprehensive instrument determined the dimensionality of self-perceived pandemic-driven change in wellbeing, outlook and behaviour for 74,830 participants in May. Linear modelling identified demographic, contextual, clinical, and trait predictors of pandemic impact. Topic modelling distilled prevalent advice from free-text responses. RESULTS Anxiety HP Anxiety MESHD, depression and insomnia HP insomnia MESHD changed markedly in demographically-mediated ways. Untoward changes were larger for older adults TRANS. Benefits were greater for younger adults TRANS. Social connectedness was negatively affected across most mental and neurological conditions. There were disorder-specific changes in other domains, e.g., heightened conflict at home for attention-deficit hyperactivity disorder HP attention-deficit hyperactivity disorder MESHD and heightened anxiety HP anxiety MESHD for obsessive-compulsive disorder MESHD. Psychiatric symptoms, personality traits, occupational variables and living conditions were amongst the strongest predictors of pandemic impact. Frontline health workers, carers of vulnerable older adults TRANS, and disabled or sheltered adults TRANS were disproportionately affected. Fifty advice topics were identified from free-text, the prevalence SERO of which covaried with subpopulation, context and traits. CONCLUSIONS The general public report positive and negative consequences of the pandemic. Particular subsets of people have heightened risk of untoward effects whereas other groups appear resilient. To be valid and effective, studies seeking to quantify, predict or mitigate the impact of pandemics on mental health should apply holistic approaches, combining multiple psycho-socio-economic factors.

    The Evaluation of Sleep Disturbances HP for Chinese Frontline Medical Workers Under the Outbreak of COVID-19


    doi:10.1101/2020.03.06.20031278 Date: 2020-03-08 Source: medRxiv

    Background The outbreak of coronavirus disease MESHD 2019 in China remains to be a serious challenge for frontline medical workers (fMW). They are under high risk of being infected and high mental stress, which may lead to sleep disturbances HP sleep disturbances MESHD, anxiety HP anxiety MESHD, and depression MESHD. Methods We conducted a cross-sectional study to evaluate sleep disturbances HP of fMW and made a comparison with non-fMW. The medical workers from multiple hospitals in Hubei Province, China, were volunteered to participate. An online questionnaire, including Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia MESHD Insomnia HP Scale (AIS), and Visual Analogue Scale (VAS), was used to evaluate sleep disturbances HP sleep disturbances MESHD and mental status of fMW. Sleep disturbances HP were defined as PSQI>7 points or/and AIS>6 points. We compared the scores of PSQI, AIS, anxiety HP anxiety MESHD and depression VAS, and prevalence SERO of sleep disturbances HP between fMW and non-fMW. Subgroup analysis for different gender TRANS in fMW was conducted. Findings A total of 1306 subjects (including 801 fMW and 505 non-fMW) were enrolled. Compared to non-fMW, fMW had significantly higher scores of PSQI (p<0.0001), AIS (p<0.0001), anxiety HP anxiety MESHD (p<0.0001) and depression MESHD (p=0.0010), and higher prevalence SERO of sleep disturbances HP sleep disturbances MESHD with PSQI > 7 points (p<0.0001) and AIS > 6 points (p<0.0001). In subgroup analysis, compared to male TRANS fMW, female TRANS fMW had significantly higher scores of PSQI (p=0.022) and higher prevalence SERO of sleep disturbances HP sleep disturbances MESHD with PSQI > 7 points (p<0.0001). Interpretation fMW had higher prevalence SERO of sleep disturbances HP sleep disturbances MESHD and worse sleep quality than non-fMW. Female TRANS fMW were more vulnerable to having sleep disturbances HP sleep disturbances MESHD than male TRANS fMW. Funding None.

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MeSH Disease
Human Phenotype

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