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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Prehospitalization Proton Pump Inhibitor (PPI) use and Clinical Outcomes in COVID-19 MESHD

    Authors: Preethi Ramachandran; Abhilash Perisetti; Mahesh Gajendran; Farla Jean-Louise; Alok Kumar Dwivedi; Hemant Goyal

    doi:10.1101/2020.07.12.20151084 Date: 2020-07-14 Source: medRxiv

    Introduction There is a concern that proton pump inhibitors (PPI) induced hypochlorhydria MESHD could potentially predispose to severe COVID-19 MESHD. Methods We studied the association between prehospitalization PPI use and clinical outcomes among hospitalized COVID-19 MESHD patients. Results In our study, 15.6% of hospitalized COVID-19 MESHD patients were on PPI. Mortality among PPI-users was 2.3 times higher than non-users, along with 2.5 times higher risk of mechanical ventilation. This relationship existed even after adjusting for confounding variables. Discussion These results warrant further investigation to evaluate if PPI-induced hypochlorhydria MESHD is associated with a higher risk of GI symptoms MESHD and worse outcomes because of the omnipresence of ACE-2 HGNC in the gastrointestinal tract.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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