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SARS-CoV-2 proteins

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    Evaluation of three rapid lateral flow antigen detection tests for the diagnosis of SARS-CoV-2 infection MESHD

    Authors: Anu E Jaaskelainen; Maarit J Ahava; Pia Jokela; Leonora Szirovicza; Sari Pohjala; Olli Vapalahti; Maija Lappalainen; Jussi Hepojoki; Satu Kurkela

    doi:10.1101/2020.12.30.20249057 Date: 2021-01-04 Source: medRxiv

    IntroductionThe COVID-19 pandemic MESHD has led to high demand of diagnostic tools. Rapid antigen detection tests have been developed and many have received regulatory acceptance such as CE IVD MESHD or FDA markings. Their performance needs to be carefully assessed. Materials and Methods158 positive and 40 negative retrospective samples collected in saline and analyzed by a laboratory-developed RT-PCR test were used to evaluate Sofia (Quidel), Standard Q (SD Biosensor), and Panbio (Abbott) rapid antigen detection tests (RADTs). A subset of the specimens was subjected to virus culture. ResultsThe specificity of all RADTs was 100% and the sensitivity and percent agreement was 80% and 85% for Sofia, 81% and 85% for Standard Q, and 83% and 86% for Panbio, respectively. All three RADTs evaluated in this study reached a more than 90% sensitivity for samples with a high viral load as estimated from the low Ct values in the reference RT-PCR. Virus culture was successful in 80% of specimens with a Ct value <25. ConclusionsAs expected, the RADTs were less sensitive than RT-PCR. However, they benefit from the speed and ease of testing, and lower price as compared to RT-PCR. Repeated testing in appropriate settings may improve the overall performance.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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