Background: In addition to the lungs, the
coronavirus disease 2019 MESHD (
COVID-19 MESHD) also affects multiple organs throughout the body. The relationship between
COVID-19 MESHD infection and cardiovascular disease MESHD, and the mechanisms by which this disease causes damage to the cardiovascular system are unclear.
Coronary heart disease MESHD (
CHD MESHD) is one of the common comorbidities of
COVID-19 MESHD, but there is insufficient evidence for its clinical features and impact on clinical outcomes. The aim of this study was to analyze the clinical characteristics of
COVID-19 MESHD patients with comorbid
CHD MESHD and the possible risk factors for the occurrence of critical illness. Methods: A single-center, retrospective study was conducted to analyze
COVID-19 MESHD patients admitted to the Sino-French New City Campus of Tongji Hospital in Wuhan, Hubei Province and treated by the Peking University National Medical Assistance Team between January 29 and
March 10 HGNC, 2020. Patients testing positive for SARS-CoV-2 viral nucleic acid in nasopharyngeal swab specimens and who had comorbid
CHD MESHD, were included in the study. Clinical data and laboratory test results of eligible patients were collected, and the factors associated with the occurrence of critical illness among these patients were evaluated. Results: A total of 205 patients were enrolled in this study, including 20
CHD MESHD patients and 185 non-
CHD MESHD patients. The mean age was 66.7 years. Compared to non-
CHD MESHD patients, more
CHD MESHD patients had comorbid
hypertension MESHD and
diabetes MESHD (P < 0.05). In terms of laboratory tests, the
CHD MESHD group did not differ significantly from the non-
CHD MESHD group in blood routine, blood chemistry, and various inflammatory cytokines. More
CHD MESHD patients experienced
myocardial injury MESHD (25% vs 8.1% P < 0.031) and
CHD MESHD patients were more likely to progress to
critical illness MESHD (40% vs 16.8%P = 0.012). Univariate logistic regression analysis indicated that a history of
CHD MESHD, occurrence of
myocardial injury MESHD, high white blood cell (WBC) count, low lymphocyte count, and elevated levels of Cr, ferritin,
IL-2R HGNC,
IL-8 HGNC at admission were factors associated with the occurrence of critical illness. Multivariate regression analysis found that a history of
CHD MESHD(OR=3.529, 95% CI =1.032-12.075, P =0.044),high WBC count(OR=1.289, 95% CI =1.136-1.463, P<0.001) and low lymphocyte count(OR=0.215, 95% CI =0.075-0.616, P =0.004)were independent factors for the occurrence of critical illness among
COVID-19 MESHD patients. Conclusion:
COVID-19 MESHD patients with comorbid
CHD MESHD commonly exhibited
myocardial injury MESHD and were prone to developing critical illness. Among
COVID-19 MESHD patients, a history of
CHD MESHD,high WBC count and low lymphocyte count were independent risk factors for the occurrence of critical illness. Greater attention and vigilance are needed in this regard during clinical practice.