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SARS-CoV-2 proteins

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    Evaluation of Myocardial Injury Patterns and ST Changes among Critical and Non-critical Patients with Coronavirus-19 Disease

    Authors: Anam Liaqat; Rao Saad Ali-Khan; Muhammad Asad; Zakia Rafique; Syed Shahzad Hasan; Amy T Page; Xiwen Simon Qin

    doi:10.21203/rs.3.rs-106298/v1 Date: 2020-11-11 Source: ResearchSquare

    Background: Novel coronavirus disease MESHD ( COVID-19 MESHD) has led to a major public health crisis globally. Currently, myocardial damage MESHD is speculated to be associated with COVID-19 MESHD, which can be seen as one of the main causes of death MESHD of patients with COVID-19 MESHD. Therefore, in this study, we aim to investigate the effects of COVID-19 MESHD diagnosed patients on myocardial injury MESHD. Methods: A prospective study was conducted among 201 patients with COVID-19 MESHD in the Pakistan Military Hospital from April 1 to August 31, 2020, including non-critical cases and critical cases. COVID-19 MESHD patients were stratified as critical and non-critical according to signs and symptoms with those requiring intensive care and ventilator support as critical and those don’t require ventilator support as non-critical Results: A total of 201 COVID-19 MESHD patients with critical and non-critical categories presented with myocardial injury MESHD. All patients with myocardial injury MESHD had an elevation in CKMB and Trop 1 HGNC levels. Of these patients, 43.7% presented with new electrocardiography (ECG) changes, ST depression MESHD is observed in 36.3% patients, and 16.9% presented with abnormal electrocardiogram findings, with right ventricular dilatation and dysfunction MESHD. Results analyzed by a logistic regression model showing COVID-19 MESHD direct contribution to myocardial injury MESHD in these patients. Conclusion:  COVID-19 MESHD disease directly leads to cardiovascular damage MESHD among critical and non-critical patients. Myocardial injury MESHD is associated not only with abnormal ECG changes but also with myocardial dysfunction MESHD on echocardiography and more commonly observed among critical patients. 

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MeSH Disease
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