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HGNC Genes

SARS-CoV-2 proteins

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SARS-CoV-2 Proteins
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    Impact of SARS-CoV-2 on Fetal Malformation During Pregnancy: A Case Report of Fetal Autopsy

    Authors: Yuping Guo; Jiacai Ren; Jingping Yuan; Di Lei; Nawsherwan .; Ying Yu; Cuifang Fan; Suqing Wang

    doi:10.21203/rs.3.rs-87715/v1 Date: 2020-10-04 Source: ResearchSquare

    Background: Little is known about the impact of SARS-CoV-2 on fetal anomalies. Case presentation: We described a case report of fetal anomalies MESHD during second-trimester (25+3 weeks) pregnancy. The fetal autopsy was found with abnormal heart anatomy MESHD (including ventricular septal defect MESHD, oval hole valve missing, and pericardial effusion MESHD), polycystic kidney MESHD, and acute chorioamnionitis MESHD. Conclusions: SARS-CoV-2 infection MESHD in second-trimester pregnancy not the direct factor resulted in congenital defects MESHD, and multiple risk factors contribute to these changes.   

    SARS-CoV-2 cell entry gene ACE2 HGNC expression in immune cells that infiltrate the placenta in infection-associated preterm birth

    Authors: Phatcharawan Lye; Caroline Dunk; Jianhong Zhang; Yanxing Wei; Jittanan Nakpu; Hirotaka Hamada; Guinever Imperio; Enrrico Bloise; Stephen M Matthews; Stephen James Lye

    doi:10.1101/2020.09.27.20201590 Date: 2020-09-29 Source: medRxiv

    COVID-19 MESHD infection during pregnancy is associated with an increased incidence of preterm birth but neonatal infection MESHD is rare. We assessed pathways by which SARS-CoV-2 could access the placenta and contribute to fetal transmission. Placentas from pregnancies complicated with chorioamnionitis MESHD ( ChA MESHD ChA HGNC), exhibited increased expression of ACE2 HGNC mRNA. Treatment of 2nd trimester placental explants with LPS, induced an acute increase in cytokine expression followed by ACE2 HGNC mRNA. Placental ACE2 HGNC protein localized to syncytiotrophoblast, in fetal blood vessels and M1/M2 macrophage and neutrophils within the villous stroma MESHD. Increased numbers of M1 macrophage and neutrophils were present in the placenta of ChA MESHD ChA HGNC pregnancies. Maternal peripheral immune cells (mainly granulocytes and monocytes) express the ACE2 HGNC mRNA and protein. These data suggest that in COVID19 MESHD positive pregnancies complicated by ChA MESHD ChA HGNC, ACE2 HGNC positive immune cells have the potential to traffic SARS-CoV-2 virus to the placenta and increase the risk of vertical transmission to the placenta/fetus.

    Further Evaluation of the Mother-to-Child Transmission Potential of SARS-CoV-2 Infection MESHD During Pregnancy: A Retrospective Study

    Authors: Xuechen Yu; Huijun Chen; Fan Luo; Juanjuan Guo; Yuan Qiao; Wei Zhang; Jiafu Li; Dongchi Zhao; Dan Xu; Qing Gong; Lingyun Yang; Pu Yang; Yuming Cao; Xue Wen; Wei Hou; Huixia Yang; Yuanzhen Zhang

    doi:10.21203/rs.3.rs-77490/v1 Date: 2020-09-14 Source: ResearchSquare

    Background. This study aimed to comprehensively evaluate the clinical characteristics of COVID-19 MESHD in perinatal period, and systematically assess the mother-to-child transmission potential of SARS-CoV-2Methods. We retrospectively analyzed the data of 23 pregnant patients in late pregnancy. Clinical specimens, including maternal and neonatal throat swabs, vaginal secretions, placenta tissues, and breast milk MESHD, were collected for the nucleic acid test of the virus. Pregnancy outcomes and neonatal results were also analyzed.Results. Overall, 10 patients (43.5%) had no symptoms and were found by routine chest CT. Complications appeared after COVID-19 MESHD onset included PROM (17.4%) and fetal distress (4.3%). Typical signs of viral pneumonia MESHD were recorded in chest CT of all patients. No patients developed severe pneumonia MESHD or died of COVID-19 MESHD. All of 25 neonates were born alive. No severe asphyxia MESHD or neonatal death MESHD was observed. Although three neonates were tested transiently suspected positive for SARS-CoV-2 after being transferred to neonatology department, no newborns developed COVID-19 MESHD. Out of various clinical specimens tested, only a rectal swab sample from one pregnant patient was tested positive for SARS-CoV-2, while all the other specimens including first sample of newborn throat swabs were negative. Pathological examination found no obvious chorioamnionitis MESHD or clear virus inclusion body in placenta, and ACE2 HGNC (angiotension-converting enzyme 2) was expressed at a moderate level.Conclusions. As in the general population of COVID-19 MESHD, asymptomatic patients were present in pregnant women. There is no confirmatory evidence for mother-to-child transmission in COVID-19 MESHD patients with late pregnancy.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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