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MeSH Disease

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SARS-CoV-2 proteins

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    Correlation of SARS-CoV-2 serology and clinical phenotype amongst hospitalised children in a tertiary children's hospital in India

    Authors: Aishwarya Venkataraman; Balasubramanian S; Sulochana Putilibai; Lakshan Raj S; Sumanth Amperayani; Senthilnathan S; Anand Manoharan; Arokia Sophi; Amutha R; Kalaimaran Sadasivam; Anu Goenka; Ramanan A V

    doi:10.1101/2021.01.29.21250660 Date: 2021-02-01 Source: medRxiv

    Introduction: Children usually present with minimal or no symptoms of SARS-CoV-2 infection MESHD. Antibody responses to SARS-CoV-2 in children from low- and middle-income countries (LMIC) have not been well described. We describe the prevalence of anti SARS-CoV-2 antibodies and clinical phenotype of seropositive children admitted to a tertiary children's hospital in South India. Methods: To determine the seropositivity and describe the clinical characteristics of SARS-CoV-2 infection MESHD amongst hospitalised children, we performed a prospective clinical data collection and blood sampling of children admitted to Kanchi Kamakoti CHILDS MESHD Trust Hospital, Chennai, India over 4 months of the COVID-19 pandemic MESHD. In seropositive children, we compared antibody titres between children with and without PIMS-TS. Results: Of 463 children, 91 (19.6%) were seropositive. The median (range) age of seropositive children was 5 years (1 month - 17 years). Clinical presentation was consistent with Paediatric inflammatory multisystem syndrome MESHD temporally associated with SARS-CoV-2 infection MESHD (PIMS-TS) in 48% (44/91) of seropositive children. The median (range) antibody titre was 54.8 (11.1-170.9) AU/ml among all seropositive children. The median antibody titre among the children with PIMS-TS (60.3 AU MESHD/mL) was significantly (p=0.01) higher when compared to the children without PIM-TS (54.8 AU MESHD/mL). Conclusion: We describe the antibody responses to SARS-CoV-2 amongst hospitalised children in a LMIC tertiary children's hospital. Almost half of the seropositive children had PIMS-TS. Antibody levels may be helpful in the diagnosis and disease stratification of PIMS-TS.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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