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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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SARS-CoV-2 Proteins
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    Early Detection of Exacerbation of the Severe Acute Respiratory Syndrome Coronavirus 2 Infection MESHD using Fitbit (DEXTERITY Pilot Study)

    Authors: Kan Yamagami; Akihiro Nomura; Mitsuhiro Kometani; Masaya Shimojima; Kenji Sakata; Soichiro Usui; Kenji Furukawa; Masayuki Takamura; Masaki Okajima; Kazuyoshi Watanabe; Takashi Yoneda

    doi:10.21203/rs.3.rs-156774/v1 Date: 2021-01-27 Source: ResearchSquare

    Some patients with coronavirus disease 2019 MESHD ( COVID-19 MESHD) experienced sudden death MESHD because of sudden symptom deterioration. Thus, an alarm system that could detect early signs of COVID-19 MESHD exacerbation beforehand, to prevent serious illness MESHD or death MESHD of patients while receiving outpatient treatment at home or in hotels is necessary. Here, we tested whether estimated oxygen variations (EOV), a relative physiological scale that represents users’ blood oxygen saturation level during sleep measured by Fitbit, predicted COVID-19 MESHD symptom exacerbation. Study period was from August to November 2020. We enrolled 23 COVID-19 MESHD patients diagnosed by SARS-CoV-2 polymerase chain reaction-positive (mean age ± standard deviation, 50.9 ± 20 years; 70% female), let each patient wore the Fitbit for 30 days; COVID-19 MESHD symptoms were exacerbated in 6 (26%). High EOV signal (a patient’s oxygen level exhibits significant dip and recovery within the index period) had 80% sensitivity before symptom exacerbations, whereas resting heart rate signal only had 50% sensitivity. Coincidental obstructive sleep apnea syndrome MESHD confirmed by polysomnography was detected in a patient by consistently high EOV signals. This pilot study successfully detected early COVID-19 MESHD symptoms exacerbation by measuring EOV and may help to identify early signs of COVID-19 MESHD exacerbation. 

    SARS-CoV-2 protein Nsp1 HGNC alters actomyosin cytoskeleton and phenocopies arrhythmogenic cardiomyopathy-related PKP2 HGNC mutant

    Authors: Cristina Marquez-Lopez; Marta Roche-Molina; Nieves García-Quintáns; Silvia Sacristan; David Siniscalco; Andrés Gonzalez-Guerra; Emilio Camafeita; Mariya Lytvyn; María Isabel Guillén; David Sanz-Rosa; Daniel Martín-Pérez; Cristina Sanchez-Ramos; Ricardo Garcia; Juan Antonio Bernal; Sijia Tao; Tristan R Horton; Elizabeth N Beagle; Ernestine A Mahar; Michelle YH Lee; Joyce Cohen; Sherrie Jean; Jennifer S Wood; Fawn Connor-Stroud; Rachelle L Stammen; Olivia M Delmas; Shelly Wang; Kimberly A Cooney; Michael N Sayegh; Lanfang Wang; Daniela Weiskopf; Peter D Filev; Jesse Waggoner; Anne Piantadosi; Sudhir P Kasturi; Hilmi Al-Shakhshir; Susan P Ribeiro; Rafick P Sekaly; Rebecca D Levit; Jacob D Estes; Thomas H Vanderford; Raymond F Schinazi; Steven E Bosinger; Mirko Paiardini

    doi:10.1101/2020.09.14.296178 Date: 2020-09-16 Source: bioRxiv

    Mutations in desmosomal Plakophilin-2 HGNC ( PKP2 HGNC) are the most prevalent drivers of arrhythmogenic-cardiomyopathy MESHD ( ACM MESHD) and a common cause of sudden death MESHD in young athletes. However, partner proteins that elucidate PKP2 HGNC cellular mechanism behind cardiac dysfunction MESHD in ACM MESHD are mostly unknown. Here we identify the actin-based motor proteins Myh9 HGNC and Myh10 HGNC as key PKP2 HGNC interactors and demonstrate that expression of the ACM MESHD-related PKP2 HGNC mutant R735X alters actin fiber organization and cell mechanical stiffness. We also show that SARS-CoV-2 Nsp1 HGNC protein acts similarly to this known pathogenic R735X mutant, altering the actomyosin component distribution on cardiac cells. Our data reveal that Nsp1 HGNC hijacks PKP2 HGNC into the cytoplasm and mimics the effect of delocalized R735X mutant. These results demonstrate that cytoplasmic PKP2 HGNC drives actomyosin deregulation and structural collapse, validating a critical role of PKP2 HGNC localization in the regulation of actomyosin architecture. The fact that Nsp1 HGNC and R735X share similar phenotypes also suggests that direct SARS-CoV-2 heart infection MESHD could induce a transient ACM MESHD-like disease in COVID-19 MESHD patients, which may contribute to right ventricle dysfunction, observed in patients with poor prognosis.

    Factors related to COVID-19 MESHD severity and mortality based on comparison between Henan and Zhejiang: an observational study

    Authors: Wangquan Ji; Ruonan Liang; Peiyu Zhu; Haiyan Yang; Shuaiyin Chen; Weiguo Zhang; Yuefei Jin; Guangcai Duan

    doi:10.21203/rs.3.rs-24420/v1 Date: 2020-04-22 Source: ResearchSquare

    Background: Coronavirus Disease 2019 MESHD ( COVID-19 MESHD) has spread across China and the world, since outbreak at the end of 2019. Although COVID-19 MESHD is generally considered as self-limiting, some of cases develop in to fatal respiratory restress, multiple organ failure MESHD and even sudden death MESHD. According to the data released by the provincial health commissions, there are obvious regional differences in COVID-19 MESHD mortality. To explore possible factors of COVID-19 MESHD related severity and mortality in laboratory-confirmed cases from Henan and Zhejiang.Methods: We collected the public data released by the government. We analyzed and compared the possible factors, including initial symptoms, gender, age, place of residence, time interval from onset to diagnosis, epidemiological history and the grade of hospital for patient’s treatment in laboratory-confirmed cases. Student’s t-test, Chi-square (c2) test, Cochran-Mantel-Haenszel (CMH) test and Mann-Whitney U rank sum test were used complied with the applicable conditions. Statistical test was performed with a level of significance α=0.05.Results: Death cases in Henan were mainly from male, elderly infected persons and those who had a history of contact with patients and underlying basic diseases. Henan had the higher proportion of cases with fever MESHD and the lower proportion of asymptomatic infection, and had higher proportions of imported male cases with a contact history, and elderly cases living in rural areas, relative to Zhejiang. The time interval of confirmed cases in rural areas of Henan was 0.8 day longer than that in Zhejiang. Hospitals grade for patients’ treatment in Henan was lower than Zhejiang.Conclusions: Our findings suggest that initial symptoms, age, place of residence, gender, the time interval from onset to diagnosis and the grade of designated hospital for patient’s treatment are possible factors behind COVID-19 MESHD related severity or mortality. This study will provide useful information for public health authorities to develop disease prevention strategies.

    Factors related to COVID-19 MESHD severity and mortality based on comparison between Henan and Zhejiang: an observational study

    Authors: Wangquan Ji; Ruonan Liang; Peiyu Zhu; Haiyan Yang; Shuaiyin Chen; Weiguo Zhang; Yuefei Jin; Guangcai Duan

    doi:10.21203/rs.3.rs-18191/v1 Date: 2020-03-19 Source: ResearchSquare

    Background: Coronavirus Disease 2019 MESHD ( COVID-19 MESHD) has spread across China and the world, since outbreak at the end of 2019. Although COVID-19 MESHD is generally considered as self-limiting, some of cases develop in to fatal respiratory restress, multiple organ failure MESHD and even sudden death MESHD. According to the data released by the provincial health commissions, there are obvious regional differences in COVID-19 MESHD mortality. To explore possible factors of COVID-19 MESHD related severity and mortality in laboratory-confirmed cases from Henan and Zhejiang.Methods: We collected the public data released by the government. We analyzed and compared the possible factors, including initial symptoms, gender, age, place of residence, time interval from onset to diagnosis, epidemiological history and the grade of hospital for patient’s treatment in laboratory-confirmed cases. Student’s t-test, Chi-square (2) test, Cochran-Mantel-Haenszel (CMH) test and Mann-Whitney U rank sum test were used complied with the applicable conditions. Statistical test was performed with a level of significance α=0.05.Results: Death cases in Henan were mainly from male, elderly infected persons and those who had a history of contact with patients and underlying basic diseases. Henan had the higher proportion of cases with fever MESHD and the lower proportion of asymptomatic infection, and had higher proportions of imported male cases with a contact history, and elderly cases living in rural areas, relative to Zhejiang. The time interval of confirmed cases in rural areas of Henan was 0.8 day longer than that in Zhejiang. Hospitals grade for patients’ treatment in Henan was lower than Zhejiang.Conclusions: Our findings suggest that initial symptoms, age, place of residence, gender, the time interval from onset to diagnosis and the grade of designated hospital for patient’s treatment are possible factors behind COVID-19 MESHD related severity or mortality. This study will provide useful information for public health authorities to develop disease prevention strategies.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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