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    Mass Drug Administration Interruption by COVID-19 MESHD reportedly increases lymphatic filarial attacks, pains, and perceived increased lymphatic filarial infection MESHD transmission in rural Ghana

    Authors: Alexander Kwarteng; Yarhands Dissou Arthur; Samuel Opoku Asiedu; John Kanyiri Yamba; Emmanuel Kobla Amewu; Efiba Vidda Senkyire Kwarteng; Samuel Terkper Ahuno

    doi:10.21203/rs.3.rs-234689/v1 Date: 2021-02-11 Source: ResearchSquare

    BackgroundLike all other diseases, the advent of the COVID-19 pandemic MESHD has been implicated to impact the elimination schedule and control of neglected tropical diseases such as human lymphatic filarial (LF) infections in endemic countries. However, it is unclear the extent to which delays in mass drug administration has affected people living with chronic lymphatic filarial pathology in rural Ghana as a result of the COVID-19 pandemic MESHD, and thus remain to be investigated. MethodTo address this, a cross-sectional study where 133 LF participants from 8 LF-endemic communities in the Ahanta West District of Ghana were recruited to assess the impact of MDA interruptions as a result of COVID-19 MESHD among individuals presenting with the filarial pathology. Here, the chi-square test of independence was used as a statistical tool to assess the dependency: 1) between MDA interruption and filarial attacks 2) between MDA interruption and filarial-related pains 3) between MDA interruption and a perceived increase in LF transmission.ResultsStudy participants were asked whether the MDA interruption has affected them in any way. Here, 81% of the patients indicated yes, it had. In addition, we sought to investigate whether MDA interruption has resulted in increased filarial attacks MESHD and pains. At this, 68% of the study respondents reported an increase in filarial attacks MESHD. Similarly, 65% reported an increase in filarial-related pains. The study further reported that filarial attacks (B=14.997, df=1, p-value <0.001) and pains MESHD (a=11.773, df=1, p-value <0.001)  are dependent on MDA interruption. Next, we further report that the perceived increase in LF transmission is dependent on MDA interruption (c=9.415, df=1, p-value=0.002).   ConclusionIn this study, MDA interruption is reported to increase filarial attacks MESHD, filarial-related pains, and a perceived LF transmission increase in the study communities. This study's findings are important and urgent, suggesting that sustained MDA interruption in LF-endemic communities could further worsen LF MESHD patients' plight as filarial attacks, pains, and transmission could increase. Therefore, the need to immediately identify alternative modes of MDA distribution in LF-endemic areas where mass treatment has been halted in the wake of COVID-19 MESHD to prevent an unwarranted surge in LF attacks, pains, and transmission.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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