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SARS-CoV-2 proteins

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SARS-CoV-2 Proteins
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    Safety of administering biologics to IBD MESHD patients at an outpatient infusion center In New York City during the COVID-19 pandemic MESHD: Sars-CoV-2 seroprevalence and clinical and social characteristics

    Authors: Serre-Yu Wong; Stephanie Gold; Emma K. Accorsi; Tori L. Cowger; Dean Wiseman; Reema Navalurkar; Rebekah Dixon; Drew S. Helmus; - CiTI Study Group; Adolfo Firpo-Betancourt; Damodara Rao Mendu; Susan Zolla-Pazner; Ken Cadwell; Jean-Frederic Colombel

    doi:10.1101/2021.03.15.21253615 Date: 2021-03-17 Source: medRxiv

    Patients with immune-mediated inflammatory diseases (IMIDs) and acquired and genetic immunodeficiencies MESHD receiving therapeutic infusions are considered high risk for SARS-CoV-2 infection MESHD. However, the seroprevalance in this group and the safety of routine administrations at outpatient infusion centers are unknown. To determine the infection rate and clinical-social factors related to SARS-CoV-2 in asymptomatic patients with IMIDs MESHD and immunodeficiencies MESHD receiving routine non-cancer therapeutic infusions, we conducted a seroprevalence study at our outpatient infusion center. We report the first prospective SARS-CoV-2 sero-surveillance of 444 IBD/IMID, immunodeficiency MESHD, and immune competent patients at an outpatient infusion center in the U.S. showing lower seroprevalence in patients compared with the general population and provide clinical and social characteristics associated with seroprevalence in this group. These data suggest that patients can safely continue infusions at outpatient centers.

    First case of COVID-19 MESHD infection in a adult patient with Ellis-van Creveld Syndrome

    Authors: Isabelle Piazza; Paolo Ferrero

    doi:10.21203/rs.3.rs-237427/v1 Date: 2021-02-12 Source: ResearchSquare

    Background: Ellis-van Creveld syndrome ( EVC MESHD) is a rare autosomal recessive disorder MESHD, the features of the syndrome are: chondral and ectodermal dysplasia MESHD characterized by short ribs, polydactyly, growth retardation MESHD resulting in dwarfism, teeth and craniofacial abnormalities and heart defects MESHD ( mostly endocardial cushions MESHD and atrial septal defects MESHD). Case presentation: We describe the first case of COVID-19 MESHD infection in a 24-years-old girl, diagnosed with EVC syndrome MESHD. The patient suffered only from a mild illness, she remained stable with normal saturation without need of neither respiratory support nor specific therapy and she was rapidly discharged.Conclusions: This case appraises the pathophiosiologic interplay between different specific prognostic variable in a syndromic patient with congenital heart disease MESHD and COVID-19 MESHD.

    Impact of SARS-CoV-2 on Fetal Malformation During Pregnancy: A Case Report of Fetal Autopsy

    Authors: Yuping Guo; Jiacai Ren; Jingping Yuan; Di Lei; Nawsherwan .; Ying Yu; Cuifang Fan; Suqing Wang

    doi:10.21203/rs.3.rs-87715/v1 Date: 2020-10-04 Source: ResearchSquare

    Background: Little is known about the impact of SARS-CoV-2 on fetal anomalies. Case presentation: We described a case report of fetal anomalies MESHD during second-trimester (25+3 weeks) pregnancy. The fetal autopsy was found with abnormal heart anatomy MESHD (including ventricular septal defect MESHD, oval hole valve missing, and pericardial effusion MESHD), polycystic kidney MESHD, and acute chorioamnionitis MESHD. Conclusions: SARS-CoV-2 infection MESHD in second-trimester pregnancy not the direct factor resulted in congenital defects MESHD, and multiple risk factors contribute to these changes.   

    Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

    Authors: Hye Kyung Lee; Ludwig Knabl; Lisa Pipperger; Andre Volland; Priscilla A. Furth; Keunsoo Kang; Harold E. Smith; Ludwig Knabl Sr.; Romuald Bellmann; Christina Bernhard; Norbert Kaiser; Hannes Ganzer; Mathias Strohle; Andreas Walser; Dorothee von Laer; Lothar Hennighausen

    doi:10.1101/2020.09.01.20185884 Date: 2020-09-02 Source: medRxiv

    To investigate prevalence of ongoing activation of inflammation MESHD following asymptomatic SARS-CoV-2 infection MESHD we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease MESHD impacting immunological activation were included ( Cystic Fibrosis MESHD ( CF MESHD), Nuclear factor-kappa B Essential Modulator ( NEMO HGNC) deficiency). CF MESHD, but not NEMO HGNC, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection MESHD ( IL1B HGNC, IL17A HGNC, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease MESHD illustrated the pathophysiological importance of context on impact of immunological response.

    Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

    Authors: Hye Kyung Lee; Ludwig Knabl; Lisa Pipperger; Andre Volland; Priscilla Furth; Keunsoo Kang; Harold Smith; Ludwig Knabl Sr.; Romuald Bellmann; Christina Bernhard; Norbert Kaiser; Hannes Gänzer; Mathias Ströhle; Andreas Walser; Dorothee Von Laer; Lothar Hennighausen

    doi:10.21203/rs.3.rs-69657/v1 Date: 2020-08-31 Source: ResearchSquare

    To investigate prevalence of ongoing activation of inflammation MESHD following asymptomatic SARS-CoV-2 infection MESHD we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease MESHD impacting immunological activation were included ( Cystic Fibrosis MESHD ( CF MESHD), Nuclear factor-kappa B Essential Modulator ( NEMO HGNC) deficiency). CF MESHD, but not NEMO HGNC, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection MESHD ( IL1B HGNC, IL17A HGNC, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease MESHD illustrated the pathophysiological importance of context on impact of immunological response.

    A mathematical epidemic model using genetic fitting algorithm with cross-validation and application to early dynamics of COVID-19 MESHD in Algeria

    Authors: Mohamed Taha Rouabah; Abdellah Tounsi; Nacer Eddine Belaloui

    id:2005.13516v4 Date: 2020-05-26 Source: arXiv

    A compartmental epidemic model based on genetic fitting algorithm MESHD and a cross-validation method to overcome the overfitting problem are proposed. This generic enhanced SEIR model allows to estimate approximate nowcast and forecast of epidemic evolution including key epidemic parameters and non-measurable asymptomatic infected portion of the susceptible population. The model is used to study COVID-19 MESHD outbreak dynamics in Algeria between February 25th and May 24th. The Basic reproduction number is estimated to 3.78 (95% CI 3.033-4.53) and effective reproduction number on May 24th after three months of the outbreak is estimated to 0.651 (95% CI 0.539-0.761). The Infections peak time is predicted to the end of April while active cases peak time is predicted to the end of May 2020. The disease incidence, CFR and IFR are calculated. Information provided by this study could help establish a realistic assessment of the situation in Algeria for the time being, inform predictions about potential future evolution, and guide the design of appropriate public health measures.

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MeSH Disease
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