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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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SARS-CoV-2 Proteins
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    Structural and metabolic brain abnormalities in COVID-19 MESHD patients with sudden loss of smell

    Authors: Maxime Niesen; Nicola Trotta; Antoine Noel; Tim Coolen; Georges Fayad; Gil Leurkin-Sterk; Isabelle Delpierre; Sophie Henrard; Niloufar Sadeghi; Jean-Christophe Goffard; Serge Goldman; Xavier De Tiège

    doi:10.1101/2020.10.18.20214221 Date: 2020-10-20 Source: medRxiv

    Objectives: Sudden loss of smell is a very common symptom of coronavirus disease MESHD 19 ( COVID-19 MESHD). This study characterizes the structural and metabolic cerebral correlates of dysosmia MESHD in patients with COVID-19 MESHD. Methods: Structural brain magnetic resonance imaging (MRI) and positron emission tomography with [18F]-fluorodeoxyglucose (FDG-PET) were prospectively acquired simultaneously on a hybrid PET-MR in twelve patients (2 males, 10 females, mean age: 42.6 years, age range: 23-60 years) with sudden dysosmia MESHD and positive detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on nasopharyngeal swab specimens. FDG-PET data were analysed using a voxel-based approach and compared with that of a group of healthy subjects. Results: Bilateral blocking of the olfactory cleft was observed in six patients, while subtle olfactory bulb asymmetry was found in three patients. No MRI signal abnormality downstream of the olfactory tract was observed. Heterogeneous (decrease or increase) glucose metabolism abnormalities MESHD were observed in core olfactory and high-order neocortical areas. A modulation of regional cerebral glucose metabolism MESHD by the severity and the duration of COVID-19 MESHD-related dysosmia MESHD was disclosed using correlation analyses. Conclusions: This PET-MR study shows that sudden loss of smell in COVID-19 MESHD is not related to central involvement due to SARS-CoV-2 neuroinvasiveness MESHD. Loss of smell is associated with heterogeneous cerebral metabolic changes in core olfactory and high-order cortical areas likely related to combined processes of deafferentation and active functional reorganisation secondary to the lack of olfactory stimulation.

    Multi-organ Proteomic Landscape of COVID-19 MESHD Autopsies

    Authors: Xiu Nie; Liujia Qian; Rui Sun; Bo Huang; Xiaochuan Dong; Qi Xiao; Qiushi Zhang; Tian Lu; Liang Yue; Shuo Chen; Xiang Li; Yaoting Sun; Lu Li; Luang Xu; Yan Li; Ming Yang; Zhangzhi Xue; Shuang Liang; Xuan Ding; Chunhui Yuan; Li Peng; Wei Liu; Xiao Yi; Mengge Lyu; Guixiang Xiao; Xia Xu; Weigang Ge; Jiale He; Jun Fan; Junhua Wu; Meng Luo; Xiaona Chang; Huaxiong Pan; Xue Cai; Junjie Zhou; Jing Yu; Huanhuan Gao; Mingxing Xie; Sihua Wang; Guan Ruan; Hao Chen; Hua Su; Heng Mei; Danju Luo; Dashi Zhao; Fei Xu; Yan Li; Yi Zhu; Jiahong Xia; Yu Hu; Tiannan Guo

    doi:10.1101/2020.08.16.20176065 Date: 2020-08-19 Source: medRxiv

    The molecular pathology of multi-organ injuries MESHD in COVID-19 MESHD patients remains unclear, preventing effective therapeutics development. Here, we report an in-depth multi-organ proteomic landscape of COVID-19 MESHD patient autopsy samples. By integrative analysis of proteomes of seven organs, namely lung, spleen, liver, heart, kidney, thyroid and testis, we characterized 11,394 proteins, in which 5336 were perturbed in COVID-19 MESHD patients compared to controls. Our data showed that CTSL HGNC, rather than ACE2 HGNC, was significantly upregulated in the lung from COVID-19 MESHD patients. Dysregulation of protein translation, glucose metabolism MESHD, fatty acid metabolism was detected in multiple organs. Our data suggested upon SARS-CoV-2 infection MESHD, hyperinflammation might be triggered which in turn induces damage of gas exchange barrier in the lung, leading to hypoxia MESHD, angiogenesis, coagulation MESHD and fibrosis MESHD in the lung, kidney, spleen, liver, heart and thyroid. Evidence for testicular injuries MESHD included reduced Leydig cells, suppressed cholesterol biosynthesis and sperm mobility. In summary, this study depicts the multi-organ proteomic landscape of COVID-19 MESHD autopsies, and uncovered dysregulated proteins MESHD and biological processes, offering novel therapeutic clues.

    Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid-19 MESHD

    Authors: Stephen Smith; Avinash Boppana; Julie A Traupman; Enrique Unson; Daniel A Maddock; Kathy Y Chao; David P Dobesh; Ruth I Connor

    doi:10.1101/2020.06.04.20122507 Date: 2020-06-05 Source: medRxiv

    Background: Identification of risk factors of severe Covid-19 MESHD is critical for improving therapies and understanding SARS-CoV-2 pathogenesis. Methods: We analyzed 184 patients hospitalized for Covid-19 MESHD in Livingston, New Jersey for clinical characteristics associated with severe disease. Results: The majority of Covid-19 MESHD patients had diabetes mellitus MESHD ( DM MESHD) (62.0%), Pre- DM MESHD (23.9%) with elevated FBG, or a BMI > 30 with normal HbA1C (4.3%). SARS-CoV-2 infection MESHD was associated with new and persistent hyperglycemia MESHD in 29 patients, including several with normal HbA1C levels. Forty-four patients required intubation, which occurred significantly more often in patients with DM MESHD as compared to non-diabetics. Conclusions: Severe Covid-19 MESHD occurs in the presence of impaired glucose metabolism MESHD in patients with SARS-CoV-2 infection MESHD. The association of dysregulated glucose metabolism MESHD and severe Covid-19 MESHD suggests a previously unrecognized manifestation of primary SARS-CoV-2 infection MESHD. Exploration of pathways by which SARS-CoV-2 impacts glucose metabolism MESHD is critical for understanding disease pathogenesis and developing therapies.

    Overall reduced lymphocyte subsets worsening disease severity and prognosis in COVID-19 MESHD severe cases with diabetes mellitus in Chengdu, China

    Authors: Dafeng Liu; Yong Wang; Lijuan Lan; Yaling Liu; Bennan Zhao; Lei Bao; Hong Chen; Min Yang; Qingfeng Li; Yilan Zeng

    doi:10.21203/rs.3.rs-20385/v2 Date: 2020-03-30 Source: ResearchSquare

    Background The outbreak of coronavirus disease 2019 MESHD ( COVID-19 MESHD) is widespread throughout China and the world. Methods Demographic, clinical data of 95 confirmed cases with COVID-19 MESHD on admission at the Public and Health Clinic Centre of Chengdu from January 16 to March 16, 2020, were retrospectively collected and analyzed. Of them 76, 19 cases were enrolled in non-DM group (without DM), DM group (with DM MESHD), respectively; according to the disease severity 57, 19, 8, 11 cases were further divided into non-severe non-DM subgroup (light and common type and without DM MESHD), severe non- DM MESHD subgroup (severe and critical illness type MESHD and without DM MESHD), non-severe DM MESHD subgroup (light and common type and with DM MESHD), severe DM MESHD subgroup (severe and critical illness type MESHD and with DM MESHD), respectively. The severe rate and the prognosis was compared between two groups. The data of peripheral lymphocyte and subsets, age, glucose metabolism MESHD parameters were compared between four subgroups, and its relationship to the disease severity, the viral negative conversion time, and the prognosis were analyzed.Results In this COVID-19 MESHD cohort the proportion of DM MESHD was 20%. Patients with DM MESHD had significantly higher severe rate and worse prognosis than those without DM MESHD, the difference was significant (severe rate ,cured, unhealed and death MESHD in DM MESHD and non-DM groups:61.11%vs.25.00%,26.32%,68.42%;5.26%vs.71.05%,26.32%,2.68%,х2=2.940, 3.394,P=0.003,0.001,respectively),simultaneously the proportion of DM MESHD in severe cases was higher than that in non-severe cases, the obvious difference was found (36.67% vs.12.31%,х2=2.744,P=0.006).Severe cases with DM MESHD tended to have the lowest lymphocytes count levels and percentage values, as well as the lowest T cells count levels and percentage values, helper T cells count levels and percentage values, suppressor T cells count levels, B cells count levels and percentage values compared with those severe cases without DM MESHD and non-severe cases with or without DM MESHD. The important influencing factors were that age, DM MESHD, lymphocyte percentage values and helper T cells percentage values for the disease severity, lymphocyte percentage values and B cell percentage values for the viral negative conversion time, and age, the disease severity and the viral negative conversion time for the prognosis.Conclusions The COVID-19 MESHD severe cases with DM MESHD had the lowest lymphocytes count level and percentage value, especially T and B lymphocytes count levels and percentage value. Overall decreased lymphocytes subsets and DM MESHD maybe worsen prognosis by worsening the disease severity and prolonging the viral negative conversion time. Combination immunomodulatory therapy based on comprehensive treatment might improve prognosis of the COVID-19 MESHD severe cases with DM MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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