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SARS-CoV-2 proteins

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    Temporal Mental Health Dynamics on Social Media

    Authors: Tom Tabak; Matthew Purver

    id:2008.13121v3 Date: 2020-08-30 Source: arXiv

    We describe a set of experiments for building a temporal mental health dynamics system. We utilise a pre-existing methodology for distant-supervision of mental health data mining from social media platforms and deploy the system during the global COVID-19 pandemic MESHD COVID-19 pandemic MESHD as a case study. Despite the challenging nature of the task, we produce encouraging results, both explicit to the global pandemic and implicit to a global phenomenon, Christmas Depression MESHD, supported by the literature. We propose a methodology for providing insight into temporal mental health dynamics to be utilised for strategic decision-making.

    Clot Waveform of APTT Has Abnormal Patterns in Subjects with COVID-19 MESHD

    Authors: Takuya Shimura; Makoto Kurano; Yoshiaki Kanno; Mahoko Ikeda; Koh Okamoto; Daisuke Jubishi; Sohei Harada; Shu Okugawa; Kyoji Moriya; Yutaka Yatomi

    doi:10.21203/rs.3.rs-43405/v1 Date: 2020-07-15 Source: ResearchSquare

    In Coronavirus disease 2019 MESHD ( COVID-19 MESHD) subjects, recent evidence suggests the presence of unique coagulation abnormalities MESHD. In this study, we performed clot waveform analyses to investigate whether specific modulations are observed in COVID-19 MESHD subjects. We analyzed the second derivative of the absorbance in routine APTT tests performed using an ACL-TOP system. We observed high frequencies of abnormal patterns in APTT second-derivative curves that could be classified into an early shoulder type, a late shoulder type, or a biphasic type, high maximum first-derivative and second-derivative peak levels, and a low minimum second-derivative peak level in COVID-19 MESHD subjects. These modulations were not observed in subjects with disseminated intravascular coagulation MESHD. These abnormal patterns are also observed in patients with lupus MESHD anticoagulant, hemophilia MESHD, or factor IX deficiency MESHD. The plasma fibrinogen HGNC levels might also be involved in the abnormal APTT waveforms, especially the high maximum first-derivative and second-derivative peak levels. The abnormal patterns in the APTT second-derivative curves appear with highest frequency at around 2 weeks after the onset of COVID-19 MESHD and were not associated with the severity of COVID-19 MESHD. These results suggest the possible presence of a specific abnormal coagulopathy MESHD in COVID-19 MESHD.

    An Analysis on the Clinical Features of MHD Patients with Coronavirus Disease 2019 MESHD: A Single Center Study

    Authors: cheng li; Min Yonglong; Tu Can; Mao Dongdong; Wan Sheng; Liu Haifeng; Xiong Fei

    doi:10.21203/rs.3.rs-18043/v1 Date: 2020-03-18 Source: ResearchSquare

    Background: In this study, we aimed to find out the features of the maintenance hemodialysis ( MHD MESHD) patients infected with Coronavirus Disease 2019 MESHD ( COVID-19 MESHD) in the Blood Purification Center of Wuhan No.1 Hospital, Hubei Province, China, and provide evidences for clinical treatment.Methods: We collected the data of all the MHD MESHD patients in this hemodialysis center by February 20, 2020, including those infected with COVID-19 MESHD. These patients were divided into three groups: the control group (537 cases), confirmed group (66 cases) and suspected group (24 cases). We compared the relevant data of the three groups and analyzed the factors that may affect the possibility of catching COVID-19 MESHD.Results: 1. By February 20, 2020, there were 627 MHD MESHD patients in the Hemodialysis Center of Wuhan No.1 Hospital. The prevalence rate of the COVID-19 MESHD was 14.35% (90/627, including 66 confirmed cases and 24 suspected cases); the fatality rate 13.33% (12/90, including 12 death MESHD cases); the mortality rate 1.91% (12/627).2. The comparison between the three groups revealed the following results: weekly hemodialysis duration ( WHD MESHD), ultrafiltration volume (UFV) and ultrafiltration rate (UFR) of the confirmed group were obviously lower than those of the control and suspected groups (P<0.05); the neutrophil ratio (N%), neutrophil (N#), monocyte (M#) and total carbon dioxide (TCO2) were significantly higher than those of the control group while the lymphocyte ratio (L%) was much lower (P<0.05).3. The lung CT scans found three common features: bilateral abnormalities (81.54%), multiple abnormalities MESHD (84.62%) and patchy opacity (61.54%).4. The binary logstic regression analysis showed that diabetes MESHD (OR=5.404,95% CI 1.950~14.976, P=0.001) and hypertension MESHD (OR=3.099,95% CI 1.380~6.963, P=0.006) are independent risk factors for MHD MESHD patients to be infected with COVID-19 MESHD; WHD (OR=0.846,95% CI 0.737~0.970, P=0.017), UFR (OR=0.012,95% CI 0.002~0.058, P<0.001) and serum ferritin (SF, OR=0.823,95% CI 0.748~0.906, P<0.001) are independent protective factors.Conclusion: MHD MESHD patients with diabetes MESHD or hypertension MESHD are more likely to be infected with COVID-19 MESHD. In clinical treatment, hemodialysis duration, UFR and SF levels should be controlled appropriately to reduce the risk of infection.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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