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SARS-CoV-2 proteins

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    SARS-CoV-2 D614 and G614 spike variants impair neuronal synapses and exhibit differential fusion ability

    Authors: Chiung-Ya Chen; Yu-Chi Chou; Yi-Ping Hsueh; Robson da Silva Ramos; Pierre Teodosio Felix Sr.; Thomas Klünemann; Doris Meier; Nora Langreder; Stephan Steinke; Rico Ballmann; Kai-Thomas Schneider; Kristian Daniel Ralph Roth; Philipp Kuhn; Peggy Riese; Dorina Schäckermann; Janin Korn; Allan Koch; Susanne Zock-Emmenthal; Marlies Becker; Margitta Scholz; Gustavo Marçal Schmidt Garcia Moreira; Esther Veronika Wenzel; Giulio Russo; Hendrikus S.P. Garritsen; Sebastian Casu; Andreas Gerstner; Günter Roth; Andreas Hermann; Thomas Schirrmann; Stefan Dübel; André Frenzel; Joop Van den Heuvel; Luka Cicin-Sain; Maren Schubert; Michael Hust

    doi:10.1101/2020.12.03.409763 Date: 2020-12-03 Source: bioRxiv

    Severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) that causes Coronavirus disease 2019 MESHD ( COVID-19 MESHD) exhibits two major variants based on mutations of its spike protein PROTEIN, i.e., the D614 prototype and G614 variant. Although neurological symptoms have been frequently reported in patients, it is still unclear whether SARS-CoV-2 impairs neuronal activity MESHD or function. Here, we show that expression of both D614 and G614 spike proteins PROTEIN is sufficient to induce phenotypes of impaired neuronal morphology, including defective dendritic spines MESHD and shortened dendritic length. Using spike protein PROTEIN-specific monoclonal antibodies, we found that D614 and G614 spike proteins PROTEIN show differential S1/S2 cleavage and cell fusion efficiency. Our findings provide an explanation for higher transmission of the G614 variant and the neurological manifestations observed in COVID-19 MESHD patients.

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MeSH Disease
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SARS-CoV-2 Proteins


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