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    Endothelial Shear Stress Enhancements: A Potential Solution for Critically Ill Covid-19 MESHD Patients

    Authors: Sayed Nour

    doi:10.21203/rs.3.rs-35793/v1 Date: 2020-06-15 Source: ResearchSquare

    Rationale: Most critically ill Covid-19 MESHD patients succumb to multiple organ failure and / or cardiac arrest MESHD as a result of comorbid endothelial dysfunction disorders MESHD which had probably aggravated by conventional mechanical assist devices. Even worse, mechanical ventilators prevent the respiratory pump from performing its crucial function as a potential generator of endothelial shear stress (ESS) which controls microcirculation and hemodynamics since birth. The purpose of this work is to bring our experience with ESS enhancement and pulmonary vascular resistance (PVR) management as a potential therapeutic solution in acute respiratory distress syndrome MESHD ( ARDS MESHD). We propose a noninvasive device composed of thoracic and infradiaphragmatic compartments that will be pulsated in an alternating frequency (20/40 bpm) with low-pressure pneumatic generator (0.1-0.5 bar). Oxygen supply, nasogastric ± endotracheal tubes are considered. Proof-of-concept: prototypes were tested in pediatric models of refractory cardiac arrest MESHD (≥20min), showed restoration of hemodynamics (BP≥100 mm Hg) and urine output, regardless of heartbeats, pharmacological supports and mechanical ventilation. Conclusions ESS enhancement represents a more effective treatment to increase tissue oxygenation and improve hemodynamic in ARDS MESHD. A cost-effective method which could be induced with a non-invasive pulsatile device adaptable to cardiopulmonary-circulatory biophysics to maintain a fully functional respiratory pump and avoid confrontation of the opposite hydraulic circuits.

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MeSH Disease
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