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SARS-CoV-2 proteins

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SARS-CoV-2 Proteins
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    COVID Symptoms, Symptom Clusters, and Predictors for Becoming a Long-Hauler:Looking for Clarity in the Haze of the Pandemic

    Authors: Yong Huang; Melissa D Pinto; Jessica L Borelli; Milad Asgari Mehrabadi; Heather Abrihim; Nikil Dutt; Natalie Lambert; Erika L Nurmi; Rana Chakraborty; Amir M Rahmani; Charles Downs

    doi:10.1101/2021.03.03.21252086 Date: 2021-03-05 Source: medRxiv

    Emerging data suggest that the effects of infection with SARS-CoV-2 are far reaching extending beyond those with severe acute disease MESHD. Specifically, the presence of persistent symptoms after apparent resolution from COVID-19 MESHD have frequently been reported throughout the pandemic by individuals labeled as long-haulers. The purpose of this study was to assess for symptoms at days 0-10 and 61+ among subjects with PCR-confirmed SARS-CoV-2 infection MESHD. The UCCORDS dataset was used to identify 1407 records that met inclusion criteria. Symptoms attributable to COVID-19 MESHD were extracted from the electronic health record, Symptoms reported over the previous year prior to COVID-19 MESHD were excluded, using nonnegative matrix factorization (NMF) followed by graph lasso to assess relationships between symptoms. A model was developed predictive for becoming a long-hauler based on symptoms. 27% reported persistent symptoms after 60 days. Women were more likely to become long- haulers, and all age groups were represented with those aged 50 +/- 20 years comprising 72% of cases. Presenting symptoms included palpitations, chronic rhinitis MESHD, dysgeusia MESHD, chills, insomnia MESHD, hyperhidrosis MESHD, anxiety MESHD, sore throat, and headache MESHD among others. We identified 5 symptom clusters at day 61+: chest pain-cough MESHD, dyspnea-cough MESHD, anxiety-tachycardia MESHD, abdominal pain-nausea MESHD, and low back pain-joint pain MESHD. Long-haulers represent a very significant public health concern, and there are no guidelines to address their diagnosis and management. Additional studies are urgently needed that focus on the physical, mental, and emotional impact of long-term COVID-19 MESHD survivors who become long-haulers.

    Elsberg Syndrome in the Setting of Asymptomatic SARS-CoV-2 infection MESHD: Case Report

    Authors: Rory M. C. Abrams; Fiona Desland; Helaina Lehrer; Anne Yeung; Winona Tse; James J. Young; Damodara R. Mendu; Barbara G. Vickrey; Susan C. Shin

    doi:10.21203/rs.3.rs-98567/v1 Date: 2020-10-26 Source: ResearchSquare

    Background: Elsberg syndrome is a rare cause of lumbosacral radiculitis MESHD with concomitant thoracic or lumbosacral myelitis MESHD that can be seen following an acute or reactivated viral infection MESHD. COVID-19 MESHD disease, caused by the SARS-CoV-2 virus, has quickly spread to a global pandemic since its first discovery in the winter of 2019. During this time, there has been an increasing number of case reports describing SARS-CoV-2 associated neuroinflammatory disease.Case Presentation: A 68-year-old man presented in June 2020 with a fall due to progressive lower extremity weakness MESHD and numbness MESHD, occurring shortly after the initial coronavirus surge in New York City. He developed ascending numbness MESHD to the level of the lower abdomen over the preceding month. He subsequently experienced low back pain MESHD, and gastrointestinal and genitourinary dysfunction MESHD. An extensive laboratory and radiologic evaluation ensued which was notable for elevated SARS-CoV-2 IgG antibodies despite an absence of preceding COVID-19 MESHD symptoms. Initial electrodiagnostic testing was notable for absent late responses in the lower extremity nerve conductions with normal distal sensorimotor conductions, and incomplete muscle activation with otherwise normal motor unit morphology and recruitment on electromyography. Repeat testing two weeks later revealed similar nerve conductions, but also the interval development of active neurogenic changes and reduced motor unit recruitment in the L3-L4 myotomes. This was suggestive of a lower thoracic and lumbosacral myelopathy and lumbosacral polyradiculopathy MESHD without peripheral neuropathy MESHD. A diagnosis of Elsberg syndrome was made and treatment with intravenous methylprednisolone yielded mild clinical improvement and the electrodiagnostic re-emergence of the lower extremity late responses.Conclusions: We report here, to our knowledge, the first case of suspected COVID-19 MESHD associated Elsberg syndrome, which may help to shed light on ways in which to approach diagnostic and treatment options in COVID-19 MESHD patients presenting with uncommon neurological and autonomic manifestations.

    Longitudinal study about low back pain, mental health, and access to healthcare system during COVID-19 MESHD COVID-19 MESHD pandemic: protocol of an ambispective cohort

    Authors: Natan Feter; Eduardo L Caputo; Igor R Doring; Jayne S Leite; Julia Cassuriaga; Felipe F Reichert; Marcelo C da Silva; Airton J Rombaldi

    doi:10.1101/2020.07.22.20160309 Date: 2020-07-24 Source: medRxiv

    This study aims to investigate the effects of physical activity before, during, and after social distancing due to the COVID-19 pandemic MESHD COVID-19 pandemic MESHD on low back pain MESHD ( LBP MESHD LBP HGNC), mental health and healthcare access. The PAMPA Cohort (Prospective Study About Mental and Physical Health) is a state-level ambispective longitudinal observational study that will be conducted in Rio Grande do Sul, Brazil. An online-based questionnaire will be used to assess LBP MESHD LBP HGNC, mental health, healthcare access and physical activity at four time points: 1) pre- COVID-19 MESHD social distancing, 2) during COVID-19 MESHD social distancing, 3) 6 months and 4) 12 months after baseline . A proportional sample size calculation was conducted, and the final sample size was estimated in 1,767 people, distributed in seven state regions. Participants will be recruited by a four-arm approach: contact with universities, social media, local media and personal contacts. Descriptive analyzes will be reported as mean or proportion and respective 95% confidence interval (CI), when appropriate. Comparison between pre- and during COVID-19 MESHD social distancing, and after baseline assessments will be performed using two-way ANOVA with repeated measures. Proportions will be compared by Chi-squared test.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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