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SARS-CoV-2 proteins

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    Chagas disease MESHD and SARS-CoV-2 coinfection MESHD does not lead to worse in-hospital outcomes: results from the Brazilian COVID-19 MESHD Registry

    Authors: Israel Molina Romero; Milena Soriano Marcolino; Magda Carvalho Pires; Lucas Emanuel Ferreira Ramos; Rafael Tavares Silva; Milton Henriques Guimaraes Junior; Isaias Jose Ramos de Oliveira; Rafael Lima Rodrigues de Carvalho; Aline Gabrielle Souza Nunes; Ana Lara Rodrigues Monteiro de Barros; Ana Luiza Bahia Alves Scotton; Angelica Aparecida Coelho Madureira; Barbara Lopes Farace; Cintia Alcantara de Carvalho; Fernanda d'Athayde Rodrigues; Fernando Anschau; Fernando Antonio Botoni; Guilherme Fagundes Nascimento; Helena Duani; Henrique Cerqueira Guimaraes; Joice Coutinho de Alvarenga; Leila Beltrami Moreira; Liege Barella Zandona; Luana Fonseca de Almeida; Luana Martins Oliveira; Luciane Kopittke; Luis Cesar de Castro; Luisa Elem Almeida Santos; Maderson Alvares de Souza Cabral; Maria Angelica Pires Ferreira; Natalia da Cunha Severino Sampaio; Neimy Ramos de Oliveira; Saionara Cristina Francisco; Sofia Jarjour Tavares Starling Lopes; Tatiani Oliveira Fereguetti; Veridiana Baldon dos Santos; Victor Eliel Bastos de Carvalho; Yuri Carlotto Ramires; Antonio Luiz Pinho Ribeiro; Freddy Antonio Brito Moscoso; Rogerio Moura; CarIsi Anne Polanczyk; Maria do Carmo Pereira Nunes

    doi:10.1101/2021.03.22.21254078 Date: 2021-03-26 Source: medRxiv

    Objective: Chagas disease MESHD ( CD MESHD) continues to be a major public health burden in Latina America, where co-infection MESHD with SARS-CoV-2 can occur. However, information on the interplay between COVID-19 MESHD and Chagas disease MESHD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD MESHD and COVID-19 MESHD, and to compare it to non- CD MESHD patients. Methods: Patients with COVID-19 MESHD diagnosis were selected from the Brazilian COVID-19 MESHD Registry, a prospective multicenter cohort, from March to September, 2020. CD MESHD diagnosis was based on hospital record at the time of admission. Study data were collected by trained hospital staff using Research Electronic Data Capture (REDCap) tools. Genetic matching for sex, age, hypertension MESHD, DM MESHD and hospital was performed in a 4:1 ratio. Results: Of the 7,018 patients who had confirmed infection with SARS-CoV-2 in the registry, 31 patients with CD MESHD and 124 matched controls were included. Overall, the median age was 72 (64.-80) years-old and 44.5% were male. At baseline, heart failure MESHD (25.8% vs. 9.7%) and atrial fibrillation MESHD (29.0% vs. 5.6%) were more frequent in CD MESHD patients than in the controls (p<0.05 for both). C-reactive protein HGNC levels were lower in CD MESHD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). Seventy-two (46.5%) patients required admission to the intensive care unit. In-hospital management, outcomes and complications were similar between the groups. Conclusions: In this large Brazilian COVID-19 MESHD Registry, CD MESHD patients had a higher prevalence of atrial fibrillation MESHD and chronic heart failure MESHD compared with non- CD MESHD controls, with no differences in-hospital outcomes. The lower C-reactive protein HGNC levels in CD MESHD patients require further investigation.

    Impact of Diabetes MESHD in Patients Waiting for Invasive Cardiac Procedures During COVID-19 Pandemic MESHD

    Authors: Raul Moreno; Jose Luis Diez; Jose Antonio Diarte; Pablo Salinas; Jose María de la Torre Hernández; Joan A Cordon; Ramiro Trillo; Juan Alonso-Briales; Ignacio Amat-Santos; Rafael Romaguera; Jose Francisco Diaz-Fernandez; Beatriz Vaquerizo; Soledad Ojeda; Ignacio Cruz-Gonzalez; Daniel Morena-Salas; Armando Perez de Prado; Fernando Sarnago; Pilar Portero; Alejandro Gutierrez-Barrios; Fernando Alfonso; Eduard Bosch; Eduardo Pinar; Jose Ramon Ruiz-Arroyo; Valeriano Ruiz-Quevedo; Jesús Jiménez-Mazuecos; Fernando Lozano; Jose Ramón Rumoroso; Enrique Novo; Francisco J Irazusta; Bruno Garcia del Blanco; José Moreu; Sara M Ballesteros-Pradas; Araceli Frutos; Manuel Villa; Eduardo Alegria-Barrero; Rosa Lazaro; Emilio Paredes

    doi:10.21203/rs.3.rs-231909/v1 Date: 2021-02-11 Source: ResearchSquare

    Background: During COVID-19 pandemic MESHD, elective invasive cardiac procedures (ICP) have been frequently cancelled or postponed. Consequences may be more evident in patients with diabetes MESHD. Objectives: The objective was to identify the peculiarities of patients with DM MESHD among those in whom ICP were cancelled or postponed due to the COVID-19 pandemic MESHD, as well as to identify subgroups in which the influence of DM MESHD has higher impact on the clinical outcome.Methods: We included 2,158 patients in whom an elective ICP was cancelled or postponed during COVID-19 pandemic MESHD in 37 hospitals in Spain. Among them, 700 (32.4%) were diabetics MESHD. Patients with and without diabetes MESHD were compared.Results: Patients with diabetes MESHD were older and had a higher prevalence of other cardiovascular risk factors, previous cardiovascular history and co-morbidities. Diabetics MESHD had a higher mortality (3.0% vs. 1.0%; p=0.001) and cardiovascular mortality (1.9% vs. 0.4%; p=0.001). Differences were especially important in patients with valvular heart disease MESHD (mortality 6.9% vs 1.7% [p<0.001] and cardiovascular mortality 4.9% vs 0.9% [p=0.002] in patients with and without diabetes MESHD, respectively). In the multivariable analysis, diabetes MESHD remained as an independent risk factor both for overall and cardiovascular mortality. No significant interaction was found with other clinical variables.Conclusion: Among patients in whom an elective invasive cardiac procedure is cancelled or postponed during COVID-19 pandemic MESHD, mortality and cardiovascular mortality is higher in patients with diabetes MESHD, irrespectively on other clinical conditions. These procedures should not be cancelled in patients with diabetes MESHD.

    Comorbidities of COVID-19 MESHD Patients with Low Cycle Threshold (Ct) Value of Nucleocapsid (N PROTEIN) Gene: An Application to Cluster-Based Logistic Model.

    Authors: Sujan Rudra; Shuva Das; Md. Ehsanul Hoque; Abul Kalam; Mohammad Arifur Rahman; Swagata Nandy Shizuka; Tazrina Rahman

    doi:10.21203/rs.3.rs-154369/v1 Date: 2021-01-25 Source: ResearchSquare

    Background: Coronavirus disease 2019 MESHD ( COVID-19 MESHD) is a health crisis throughout the world. The widely used Real-time Reverse Transcriptase Polymerase Chain Reaction (rRT-PCR) method is most capable of describing the patient’s condition. Comorbidities can make patients more critical.Methods: In this study, we shed light on the low cycle threshold (Ct) value of the N gene PROTEIN in the rRT-PCR test of the COVID-19 MESHD patients who had comorbidities, cure rate, and the needfulness of ICU (Intensive Care Unit) management. We had conducted the research in the Molecular Biology Laboratory of Chittagong Medical College between May and August 2020, then took the telephone interview with 300 positive patients who fulfilled the study criteria. We applied cluster-based logistic regression to analyze the data.Results: Low Ct value of the N gene PROTEIN found 1.324 times more in Type 2 DM MESHD patients and 1.871 times higher in hypertensive MESHD patients, and hospitalized patients are 2.480 times more vulnerable to shift in ICU.Conclusions: While infection with Severe Acute Respiratory Syndrome Coronavirus 2 MESHD (SARS-CoV-2) frequently causes severe diseases MESHD, suspected cases with comorbid conditions should go through the rRT-PCR as early as possible.

    Comorbidities of COVID-19 MESHD Patients With Low Cycle Threshold (Ct) Value of Nucleocapsid (N PROTEIN) Gene: An Application to Cluster-Based Logistic Model.

    Authors: SUJAN RUDRA; SHUVA DAS; MD. EHSANUL HOQUE; ABUL KALAM; MOHAMMAD ARIFUR RAHMAN; SWAGATA NANDY SHIZUKA; TAZRINA RAHMAN

    doi:10.21203/rs.3.rs-147576/v2 Date: 2021-01-14 Source: ResearchSquare

    Background: Coronavirus disease 2019 MESHD ( COVID-19 MESHD) is a health crisis throughout the world. The widely used Real-time Reverse Transcriptase Polymerase Chain Reaction (rRT-PCR) method is most capable of describing the patient’s condition. Comorbidities can make patients more critical.Methods: In this study, we shed light on the low cycle threshold (Ct) value of the N gene PROTEIN in the rRT-PCR test of the COVID-19 MESHD patients who had comorbidities, cure rate, and the needfulness of ICU (Intensive Care Unit) management. We had conducted the research in the Molecular Biology Laboratory of Chittagong Medical College between May and August 2020, then took the telephone interview with 300 positive patients who fulfilled the study criteria. We applied cluster-based logistic regression to analyze the data.Results: Low Ct value of the N gene PROTEIN found 1.324 times more in Type 2 DM MESHD patients and 1.871 times higher in hypertensive MESHD patients, and hospitalized patients are 2.480 times more vulnerable to shift in ICU.Conclusions: While infection with Severe Acute Respiratory Syndrome Coronavirus 2 MESHD (SARS-CoV-2) frequently causes severe diseases MESHD, suspected cases with comorbid conditions should go through the rRT-PCR as early as possible.

    Evaluation of Patients With Covid-19 MESHD Diagnosis for Chronic Diseases MESHD

    Authors: Murat Altuntas; Habip Yilmaz; Emre Güner

    doi:10.21203/rs.3.rs-135761/v1 Date: 2020-12-24 Source: ResearchSquare

    Aim: Covid-19 MESHD is one of the most important pandemics in the world history. Chronic diseases MESHD, which are risk factors that increase the case fatality rates, have been the leading cause of death MESHD all over the world. In this study, it was aimed to detect coexisting diseases in patients hospitalized with the diagnosis of Covid-19 MESHD.           Material and Method: It was carried out with the data of 229 inpatients in an intensive care unit between 01.06.2020 - 30.06.2020. Among the inclusion criteria of the study; it is necessary to have a diagnosis confirmed by PCR test, to be hospitalized in the relevant intensive care unit on the date of the study and to have data accessible through the hospital automation system. According to literature; chronic diseases of the patients and their effects on the covid-19 MESHD process were evaluated. Statistical analyzes were performed using the Statistical Package for Social Sciences (SPSS) version 24.0 (IBM Corp .; Armonk, NY, USA).Results: It was seen that the average age of the patients were 61.4±15.9 years old. While the average symptom duration was 8.2±5.3 days; total hospitalization period was 13.1±5.9 days. The length of stay of 75 patients who were sent to intensive care unit was determined as 10.1±7.1. The most common chronic disease MESHD among patients was hypertension MESHD with 47.2%. This was followed by diabetes mellitus MESHD (32.8%) and heart disease MESHD (27.5%), respectively. In the presented study, cough MESHD (59.4%), fever MESHD (58.5%) and shortness of breath MESHD (45.9%) were found to be the most common symptoms. Leukopenia MESHD, impairments in liver and muscle enzymes, abnormal C-reactive protein HGNC, ferritin and d-dimer levels were the important laboratory findings.Conclusion: Particular attention should be paid to the elderly Covid-19 MESHD patients with chronic diseases MESHD, especially DM MESHD, HT MESHD and cancer MESHD.

    Hyperglycemic Hyperosmolar MESHD State (HHS) with New-onset Diabetes Mellitus MESHD in a Patient with SARS CoV-2 Infection MESHD.

    Authors: Awaji Q. Al-Naami; Liaqat A. Khan; Faisal I. Zaidan; Ibrahim A. Al-Neami; Akram S. Awad; Abdulwahab I. Hobani; Ali H. Sheikh; Mousa A. Ahmadini

    doi:10.21203/rs.3.rs-116397/v1 Date: 2020-11-26 Source: ResearchSquare

    New-onset DM MESHD or unmasking existing one, with or without metabolic complications, has been reported in SARS CoV-2 infection MESHD. New-onset DM MESHD in association with HHS alone or combination with DKA is uncommon but a possible manifestation of SARS CoV-2 infection MESHD that poses management challenges where the outcome may be worst.

    Overall Reduced Baseline Lymphocyte Subsets Closely Related to the Poor Prognosis and the Disease Severity in Patients With COVID-19 MESHD and Diabetes Mellitus

    Authors: Dafeng Liu; yong Wang; Bennan Zhao; Lijuan Lan; Yaling Liu; Lei Bao; Hong Chen; Min Yang; Qingfeng Li; Yilan Zeng

    doi:10.21203/rs.3.rs-100003/v1 Date: 2020-10-29 Source: ResearchSquare

    IntroductionDysregulated host immune response was common in COVID-19 MESHD. In this study we aimed at the characteristics of lymphocyte subsets and its relationship with the disease progression in COVID-19 MESHD patients with or without DM MESHD.MethodsThe baseline peripheral lymphocyte and subsets were compared between 55 healthy cases (control group) and 95 confirmed cases with COVID-19 MESHD ( COVID-19 MESHD group), and between COVID-19 MESHD patients with and without DM MESHD.ResultsThe prevalence of DM MESHD in COVID-19 MESHD group was 20%, and severe cases had higher the prevalence of DM MESHD than non-severe cases (P=0.006), moreover significantly poor prognosis and higher severe rate were found in those with DM MESHD relative to those without DM MESHD (P=0.001,0.003, respectively). In COVID-19 MESHD group overall and significant reduced lymphocyte and subsets, especially B and T lymphocytes were found, especially in those with DM MESHD. Partial decreased lymphocyte subsets, age and DM MESHD closely related with the disease progression and the prognosis.ConclusionsThese findings provide a reference for clinicians that immunomodulatory treatment maybe improve disease progression and prognosis of COVID-19 MESHD patients, especially those with DM MESHD.

    Survival and 30-days hospital outcome in hospitalized COVID-19 MESHD patients in Upper Egypt: Multi-center study

    Authors: Aliae Mohamed-Hussein; Islam Galal; Mohammed Mustafa Abdel Rasik Mohamed; Mohamed Eltaher AA Ibrahim; Shazly Baghdady Ahmed

    doi:10.1101/2020.08.26.20180992 Date: 2020-09-01 Source: medRxiv

    Background: Determining the clinical features and outcomes of patients diagnosed with COVID-19 MESHD is fundamental to improve the understanding and adequate management of the novel illness. This study aims to identify the basic demography, underlying comorbidities and the mortality related factors of hospitalized patients with COVID-19 MESHD in Upper Egypt. Patients and methods: 1064 cases consecutively admitted to isolation hospitals in Upper Egypt. All cases had confirmed COVID-19 MESHD infection. The electronic records of the patients were retrospectively revised and the demographic data, clinical manifestations, qSOFA score on admission and 30 days-outcome (ICU admission, death MESHD, recovery, referral or still in hospital) were analyzed. Overall cumulative survival in all patients and those > or < 50 years were calculated. Results 49.2% of the study population were males while 50.8% females with mean age 49.4 years-old. On admission, 83.9% were stable with qSOFA score < 1, 3% required non- invasive mechanical ventilation, and 2.1% required O2 therapy. Within 30 days, 203 cases (19.1%) required admission to ICU. Death was recorded in 11.7% of cases, 28.7% recovered, 40.5% referred and 19.2% were still under treatment. Determinants of ICU admission and survival in the current study were age > 50, respiratory rate > 24/minute, SaO2 < 89%, qSOFA >1 and need for O2 therapy or NIV. The cumulative survival was 75.3% with the mean survival was 28.1, and 95.2% overall survival was recorded in those aged < 50 years. Conclusions Age older than 50 years old, those with pre-existing DM MESHD, initial qSOFA score, requirement for O2 therapy and NIV from the first day of hospital admission may be associated with unfavorable 30 days- in hospital outcome of COVID- 19.

    Factors associated with the poor outcomes in diabetic patients with COVID-19 MESHD

    Authors: Hadith Rastad; Hanieh-Sadat Ejtahed; Armita Mahdavi-Ghorabi; Anis Safari; Ehsan Shahrestanaki; Mohammad Rezaei; Mohammad Mahdi Niksima; Akram Zakani; Seyede Hanieh Dehghan Manshadi; Fatemeh Ochi; Shabnam saedi; Zeinab Khodaparast; Neda Shafiabadi Hassani; Mehdi Azimzadeh; Mostafa Qorbani

    doi:10.21203/rs.3.rs-56358/v1 Date: 2020-08-09 Source: ResearchSquare

    Background Diabetic MESHD’s patients are supposed to experience higher rates of COVID-19 MESHD related poor outcomes. We aimed to determined factors predicting poor outcomes in hospitalized diabetic MESHD patients with COVID-19 MESHD.Methods This retrospective cohort study included all adult diabetic MESHD patients with radiological or laboratory confirmed COVID-19 MESHD who hospitalized between 20 February 2020 and 27 April 2020 in Alborz province, Iran. Data on demographic, medical history, and laboratory test at presentation were obtained from electronic medical records. Diagnosis of diabetes mellitus MESHD was self-reported. Comorbidities including cancer MESHD, rheumatism, immunodeficiency MESHD, or chronic diseases of respiratory, liver, and blood were classified as “other comorbidities” due to low frequency. The assessed poor outcomes were in-hospital mortality, need to ICU care, and receiving invasive mechanical ventilation. Self-reported. Multivariate logistic regression models were fitted to quantify the predictors of in-hospital mortality from COVID-19 MESHD in patients with DM MESHD.Results Of 455 included patients, 98(21.5%) received ICU care, 65(14.3%) required invasive mechanical ventilation, and 79 (17.4%) dead. In the multivariate model, significant predictors of “death of COVID-19 MESHD” were age 65 years or older (OR (95% CI): 2.0 (1.16–3.44), chronic kidney disease (CKD) (2.05 (1.16–3.62), presence of “other comorbidities” (2.20 (1.04–4.63)), neutrophil count ≥ 8.0 × 10⁹/L )6.62 (3.73–11.7 ((, Hb level < 12.5 g/dl (2.05 (1.13–3.72) (, and creatinine level ≥ 1.36 mg/dl (3.10 (1.38–6.98)). (All p –values < 0.05). Some of these factors were also associated with other assessed poor outcomes, e.g., need to ICU care or invasive mechanical ventilation.Conclusions Diabetic patients with age 65 years or older, comorbidity CKD, “other comorbidities”, as well as neutrophil count ≥ 8.0 × 10⁹/L, Hb level < 12.5 g/dl, and creatinine level ≥ 1.36 mg/dl, were more likely to dead after COVID-19 MESHD. Presence of hypertension and cardiovascular disease were associated with none of the poor outcomes.

    Early Diagnosis and Clinical Significance of Acute Cardiac Injury - Under the Iceberg: A Retrospective Cohort Study of 619 Non-critically Ill Hospitalized COVID-19 MESHD Pneumonia Patients

    Authors: Yang Xie; Sichun Chen; Xueli Wang; Baige Li; Tianlu Zhang; Xingwei He; NingLing Sun; Luyan Wang; Hesong Zeng; Yin Shen

    doi:10.1101/2020.07.06.20147256 Date: 2020-07-07 Source: medRxiv

    Rationale: Coronavirus disease 2019 MESHD ( COVID-19 MESHD) can cause a viral pneumonia MESHD together with other extrapulmonary complications. Acute cardiac related injury (ACRI) is common in hospitalized COVID-19 MESHD patients. Objective: To explain the pathological mechanism of ACRI and improve the treatment strategy by retrospectively observing the factors associated with ACRI and factors affecting the prognosis of ACRI with COVID-19 MESHD at an early stage. Methods: 619 COVID-19 MESHD patients were from Tongji Hospital, Wuhan. T test was used for continuous variables while Chi-square test for categorical factors. Univariable and multivariable logistic regression models were applied to estimate odds ratio (OR) with 95% confidence interval (CI). Results: Among the 619 OOS Level-I hospitalized COVID-19 MESHD patients, 102 (16.5%) were defined as ACRI (stage-1: 59 cases, stage-2: 43 cases). 50% of ACRI patients developed into severe cases and 25 patients died (CFR=24.5%), 42 times that of non-ACRI patients. Elderly (OR=2.83, P<0.001) , HTN (OR=2.09, P=0.005), {gamma}-globulin (OR=2.08, P=0.004), TCM (OR=0.55, P=0.017), PLT (OR=2.94, P<0.001) and NLR (OR=2.20, P=0.004) were independently correlated with ACRI. SBP HGNC[≥]140, dyspnea MESHD, DM MESHD, smoking history were correlated with ACRI-stage2 only. In the prognostic subgroup analysis of ACRI patients,{gamma}-globulin treatment could prolong LOS. TCM (OR=0.26, P=0.006), SBP HGNC[≥]160 (OR= 22.70, P=0.005), male (OR=2.66, P=0.044) were associated with severe illness while corticosteroids treatment (OR=3.34, P=0.033) and male (OR=4.303, P=0.008) with death MESHD. Surprisingly, we found the mortality of non-elderly patients is higher than elderly (32.4% VS 20.0%, P=0.164), and both IKF and RASI treatment were not correlated with any prognostic indicators including severe, death MESHD and LOS. Conclusion: This study observed that several non-traditional issues were associated with early cardiac injury MESHD in COVID-19 MESHD while many traditional cardiovascular risk factors were not. Besides elderly and male, hypertension MESHD was confirmed to be the most important risk factor.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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