Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

NSP5 (1)

ProteinS (1)

NSP2 (1)


SARS-CoV-2 Proteins
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    Teleradiology as a relevant indicator of the impact of COVID-19 pandemic MESHD management on Emergency Room activities: a nationwide worrisome survey

    Authors: Jordan Vatele; Stephanie Gentile; Vivien THOMSON; Bénédicte DEVICTOR; Marine CLOUX; Nicolas GIROUIN; Flavie BRATAN; Jean-François BERGEROT; Mylène SEUX; Nathan BANASTE; Karim TAZAROURTE; Guillaume GORINCOUR

    doi:10.21203/ Date: 2020-11-03 Source: ResearchSquare

    Objectives: To evaluate the impact of COVID-19 MESHD’s lockdown on radiological examinations in Emergency Services.Methods: Retrospective, multicentre analysis of radiological examinations requested, via our teleradiology network, from 2017 to 2020 during two timeframes (calendar weeks 5 to 8 and then 12 to 15).We included CT-scans or MRIs performed for strokes MESHD, multiple traumas MESHD (body-CT, BC), cranial traumas MESHD ( CTr HGNC CTr MESHD) and acute non-traumatic abdominal pain MESHD (ANTAP). We evaluated the number and percentages of examinations performed, of those with a pathological conclusion, and of examinations involving the chest.Results: Our study included 25 centres in 2017, 29 in 2018, 43 in 2019 and 59 in 2020.From 2017 to 2019, the percentages of examinations were constant, which was also true for chest CTs. Each centre’s number of examinations, gender distribution and patient ages were unchanged.In 2020, examinations significantly decreased : suspected strokes MESHD decreased by 36% (1052 vs 675, p <0.001), BC by 62% (349 vs 134, p <0.001), CTr HGNC CTr MESHD by 52% (1853 vs 895, p <0.001) and for ANTAP, appendicitis MESHD decreased by 38% (145 vs 90, NS MESHD) sigmoiditis MESHD by 44% (98 vs 55, NS), and renal colic by 23% (376 vs 288, NS MESHD).The number of exams per centre decreased by 13% (185.5 vs. 162.5, p <0.001) whereas the number of examinations of the "chest" region increased by 170% (1205 vs 3766, p <0.001).Conclusion: Teleradiology enabled us to monitor the impact of the COVID-19 pandemic MESHD management on emergency activities, showing a global decrease in the population's use of care

    Sensitivity of nasopharyngeal swabs and saliva for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

    Authors: Alainna J. Jamal; Mohammad Mohammad; Eric Coomes; Jeff Powis; Angel Li; Aimee Paterson; Sofia Anceva-Sami; Shiva Barati; Gloria Crowl; Amna Faheem; Lubna Farooqi; Saman Khan; Karren Prost; Susan Poutanen; Lily Yip; Zoe Zhong; Allison J McGeer; Samira Mubareka

    doi:10.1101/2020.05.01.20081026 Date: 2020-05-05 Source: medRxiv

    We enrolled 53 consecutive in-patients with COVID-19 MESHD at six hospitals in Toronto, Canada, and tested one nasopharyngeal swab/saliva sample pair from each patient for SARS-CoV-2. Overall, sensitivity was 89% for nasopharyngeal swabs and 77% for saliva (p= NS MESHD); difference in sensitivity was greatest for sample pairs collected later in illness.

    Active-site Molecular docking of Nigellidine to nucleocapsid/ Nsp2 HGNC/ Nsp3 HGNC/MPro of COVID-19 MESHD  and to human IL1R HGNC and TNFR1/2 may stop viral-growth/cytokine-flood, and the drug source Nigella sativa (black cumin) seeds show potent antioxidant role in experimental rats.

    Authors: Smarajit Maiti; Amrita Banerjee; Aarifa Nazmeen; Mehak Kanwar; Shilpa Das

    doi:10.21203/ Date: 2020-05-02 Source: ResearchSquare

    The recent outbreak of SARS CoV-2 has changed the global scenario of human lives and economy. In this pandemic-outbreak the ratio of infected person is much higher than the death encountered. Most of the dead patients were observed with dysfunction/failure of cardiac and renal systems MESHD. Beside this a ‘cytokine storm’ namely TNF-α HGNC/ IL1 HGNC receptors i.e. TNFR1 HGNC/ TNFR2 HGNC/ IL1R HGNC over-functioning was reported in the infected-persons. Here, nigellidine, an indazole-alkaloid and key-component of Nigella Sativa L. ( NS MESHD); black-cumin-seed, has been analyzed for COVID-19 MESHD different protein and TNFα receptors TNFR1 HGNC/ TNFR2 HGNC and IL1R HGNC inhibition through molecular-docking study and biochemical-study of cumin-seed extract exposure to experimental-rat. The NMR, X-ray-crystallographic or Electron-microscopic structures of COVID-19 MESHD Main-protease PROTEIN(6LU7), Spike-glycoprotein PROTEIN(6vsb), NSP2 HGNC NSP2 PROTEIN(QHD43415_2), N-terminus-protenase (QHD43415_3), Nucleocapsid(QHD43423) and Human IL1R HGNC (1itb), TNFR1 HGNC (1ncf), TNFR2 HGNC (3alq) from PDB MESHD were retrieved/analyzed for receptor-ligand interaction in normal condition. Then those structures were docked with nigellidine using Autodock-software and Patchdock-server. Where nigellidine showed highest binding-energy of -7.61 (kcal/mol) and ligand-efficiency value of (-0.35) forming bonds with amino acids THR943/LYS945/MET1556/ALA1557/PRO1558/ILE1559. Highest ACE-value of -356.72 was also observed for nigellidine N-terminal-protease interaction. Nigellidine also showed strong interaction with NSP2 HGNC NSP2 PROTEIN (-6.28) and Mpro PROTEIN/3CLpro_Q (-6.38s). Nigellidine showed affinity to TNFR1 HGNC (-6.81), IL1R HGNC (-6.23) and TNFR2 HGNC (-5.16). In rat experiment 2-groups (vehicle and NS treated) of female Wistar-rats were taken for experiments. The NS treated tissue showed marked decline in ALP MESHD/SGPT/ SGOT/MDA level then the basal-levels. From the Western-blot or activity analysis it was observed that Nigellidine, the sulfuryl-group containing drug showed no impact on Phenol-catalyzing ASTIV or Steroid-catalyzing EST expressions/activities and thus have no influence in sulfation-mediated adverse metabolic-processes. Current-results concluded that Nigellidine has hepato/reno-protective; immunomodulatory/anti-inflammatory and antioxidant activities as well as it inhibits important proteins of COVID-19 MESHD. With steps to further validation/checking nigellidine can be used in COVID-19 MESHD infection.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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