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SARS-CoV-2 proteins

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    Ovarian follicular function is not altered by SARS-Cov-2 infection MESHD or BNT162b2 mRNA Covid-19 MESHD vaccination.

    Authors: Yaakov Bentov; Ofer Beharier; Arbel Moav-Zafrir; Maor Kabessa; Miri Godin; Caryn Greenfield; Mali Ketzinel-Gilad; Efrat Esh Broder; Hananel Holzer; Dana Wolf; Esther Oiknine-Djian; Iyad Barghouti; Debra Goldman-Wohl; Simcha Yagel; Asnat Walfisch; Anat Hershko Klement

    doi:10.1101/2021.04.09.21255195 Date: 2021-04-13 Source: medRxiv

    Importance: This is the first study to examine the impact of SARS-Cov-2 infection MESHD and COVID-19 MESHD vaccination on ovarian function. Objective: To characterize anti- COVID-19 MESHD antibodies in follicular fluid and compare ovarian follicle function in women following confirmed SARS-CoV-2 infection MESHD, COVID-19 MESHD vaccination, and non-infected MESHD, unvaccinated controls. Design: This is a cohort study conducted between February 1 and March 10, 2021. Setting: A single university hospital-based IVF clinic. Participants: Consecutive sample of female patients undergoing oocyte retrieval. Interventions: Consenting patients were recruited and assigned to one of three study groups: recovering from confirmed COVID 19 (n=9); vaccinated (n=9); and uninfected, non-vaccinated controls (n=14). Serum and follicular fluid samples were taken and analyzed for anti-COVID IgG as well as estrogen, progesterone and HSPG2 HGNC concentration, as well as the number and maturity of aspirated oocytes and previous estrogen and progesterone measurements. Main outcome measures: Follicular function, including steroidogenesis, follicular response to the LH/hCG trigger, and oocyte quality biomarkers. Results: Both natural and vaccine elicited anti-COVID IgG antibodies were detected in the follicular fluid in levels proportional to the IgG serum concentration. No differences were detected in any of the surrogate ovarian follicle quality reporting parameters. Conclusions and relevance: Both SARS-COV-2 infection MESHD and vaccination with the BNT162b2 mRNA vaccine mediate IgG immunity that crosses into the follicular fluid. No detrimental effect on follicular function was detected.

    High incidence of pulmonary thromboembolism MESHD in hospitalized SARS-CoV-2 infected MESHD patients

    Authors: DAVID EL-QUTOB Sr.; Laura Alvarez; Patricia Garcia; Montserrat Robustillo; Ines Barreda; MARIA NIETO; Maria Teresa Pin; Francisco Javier Carrera

    doi:10.1101/2021.03.23.21253258 Date: 2021-03-24 Source: medRxiv

    Introduction SARS-CoV-2 infected MESHD patients present thrombotic complications MESHD caused by direct endothelial cells injury of the microvessels. Pulmonary thromboembolism MESHD ( PE MESHD) has been reported by Computed Tomography pulmonary angiogram (CTPA) in patients with COVID-19 MESHD pneumonia MESHD with high D-dimer levels. Objectives We present the characteristics of SARS-CoV-2 infected MESHD patients diagnosed of PE MESHD by CTPA in our hospital. We also present the comparison of these findings with non-infected MESHD patients with PE MESHD data. Methods Patients 18 years of age or older with SARS-CoV2 virus infection MESHD, and patients with suspected infection at beginning of admission but with negative PCR, were studied with CTPA for suspicion of VTE MESHD, during their hospitalization. Results During the study period, 52 CTPA were performed in our hospital, sixteen in SARS-CoV-2 infected MESHD patients. No significant differences in age (p=0.43) and sex (p=0.31) were found between the two groups, infected and non-infected MESHD patients. In the infected group, the patients who had PE MESHD had a much lower median age (47.8 years) than those without PE MESHD (73.3 years). No differences between infected and non-infected MESHD patients were detected in the diagnosis of PE MESHD with CTPA, 28.6% versus 27.8% (p=1.00). Overall patient mortality was 1.9%; one patient died (6.3%) in the infected group, and none in the non-infected group (p=0.31). Conclusion A considerable incidence of PE MESHD diagnosed by CTPA in SARS-CoV-2 infected MESHD patients has been observed, despite thrombo-prophylaxis.

    Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

    Authors: Salwa Naushin; Viren Sardana; Rajat Ujjainiya; Nitin Bhatheja; Rintu Kutum; Akash Kumar Bhaskar; Shalini Pradhan; Satyartha Prakash; Raju Khan; Birendra Singh Rawat; Giriraj Ratan Chandak; Karthik Bharadwaj Tallapaka; Mahesh Anumalla; Amit Lahiri; Susanta Kar; Shrikant Ramesh Mulay; Madhav Nilakanth Mugale; Mrigank Srivastava; Shaziya Khan; Anjali Srivastava; Bhawna Tomar; Murugan Veerapandian; Ganesh Venkatachalam; Selvamani Raja Vijayakumar; Ajay Agarwal; Dinesh Gupta; Prakash M Halami; Muthukumar Serva Peddha; Gopinath M; Ravindra P Veeranna; Anirban Pal; Vinay Kumar Agarwal; Anil Ku Maurya; Ranvijay Kumar Singh; Ashok Kumar Raman; Suresh Kumar Anandasadagopan; Parimala Karupannan; Subramanian Venkatesan; Harish Kumar Sardana; Anamika Kothari; Rishabh Jain; Anupma Thakur; Devendra Singh Parihar; Anas Saifi; Jasleen Kaur; Virendra Kumar; Avinash Mishra; Iranna Gogeri; Geetha Vani Rayasam; Praveen Singh; Rahul Chakraborty; Gaura Chaturvedi; Pinreddy Karunakar; Rohit Yadav; Sunanda Singhmar; Dayanidhi Singh; Sharmistha Sarkar; Purbasha Bhattacharya; Sundaram Acharya; Vandana Singh; Shweta Verma; Drishti Soni; Surabhi Seth; Firdaus Fatima; Shakshi Vashisht; Sarita Thakran; Akash Pratap Singh; Akanksha Sharma; Babita Sharma; Manikandan Subramanian; Yogendra Padwad; Vipin Hallan; Vikram Patial; Damanpreet Singh; Narendra Vijay Tirpude; Partha Chakrabarti; Sujay Krishna Maity; Dipyaman Ganguly; Jit Sarkar; Sistla Ramakrishna; Balthu Narender Kumar; Kiran A Kumar; Sumit G. Gandhi; Piyush Singh Jamwal; Rekha Chouhan; Vijay Lakshmi Jamwal; Nitika Kapoor; Debashish Ghosh; Ghanshyam Thakkar; Umakanta Subudhi; Pradip Sen; Saumya Raychaudhri; Amit Tuli; Pawan Gupta; Rashmi Kumar; Deepak Sharma; Rajesh P. Ringe; Amarnarayan D; Mahesh Kulkarni; Dhanasekaran Shanmugam; Mahesh Dharne; Syed G Dastager; Rakesh Joshi; Amita P. Patil; Sachin N Mahajan; Abu Junaid Khan; Vasudev Wagh; Rakeshkumar Yadav; Ajinkya Khilari; Mayuri Bhadange; Arvindkumar H. Chaurasiya; Shabda E Kulsange; Krishna khairnar; Shilpa Paranjape; Jatin Kalita; G.Narahari Sastry; Tridip Phukan; Prasenjit Manna; Wahengbam Romi; Pankaj Bharali; Dibyajyoti Ozah; Ravi Kumar Sahu; Elapaval VSSK Babu; Rajeev K Sukumaran; Aishwarya R Nair; Anoop Puthiyamadam; Prajeesh Kooloth Valappil; Adarsh Velayudhanpillai; Kalpana Chodankar; Samir Damare; Yennapu Madhavi; Ved Varun Agrawal; Sumit Dahiya; Anurag Agrawal; Debasis Dash; Shantanu Sengupta

    doi:10.1101/2021.01.12.21249713 Date: 2021-01-16 Source: medRxiv

    BackgroundIndia has been amongst the most affected nations during the SARS-CoV2 pandemic, with sparse data on country-wide spread of asymptomatic infections and antibody persistence. This longitudinal cohort study was aimed to evaluate SARS-CoV2 sero-positivity rate as a marker of infection and evaluate temporal persistence of antibodies with neutralization capability and to infer possible risk factors for infection. MethodsCouncil of Scientific and Industrial Research, India (CSIR) with its more than 40 laboratories and centers in urban and semi-urban settings spread across the country piloted the pan country surveillance. 10427 adult individuals working in CSIR laboratories and their family members based on voluntary participation were assessed for antibody presence and stability was analyzed over 6 months utilizing qualitative Elecsys SARS CoV2 specific antibody kit and GENScript cPass SARS-CoV2 Neutralization Antibody Detection Kit. Along with demographic information, possible risk factors were evaluated through self to be filled online forms with data acquired on blood group type, occupation type, addiction and habits including smoking and alcohol, diet preferences, medical history and transport type utilized. Symptom history and information on possible contact and compliance with COVID 19 universal precautions was also obtained. Findings1058 individuals (10{middle dot}14%) had antibodies against SARS-CoV2. A follow-up on 346 sero-positive individuals after three months revealed stable to higher antibody levels against SARS-CoV2 but declining plasma activity for neutralizing SARS-CoV2 receptor binding domain and ACE2 HGNC interaction. A repeat sampling of 35 individuals, at six months, revealed declining antibody levels while the neutralizing activity remained stable compared to three months. Majority of sero-positive individuals (75%) did not recall even one of nine symptoms since March 2020. Fever MESHD was the most common symptom with one-fourth reporting loss of taste or smell. Significantly associated risks for sero-positivity (Odds Ratio, 95% CI, p value) were observed with usage of public transport (1{middle dot}79, 1{middle dot}43 - 2{middle dot}24, 2{middle dot}81561E-06), occupational responsibilities such as security, housekeeping personnel etc. (2{middle dot}23, 1{middle dot}92 - 2{middle dot}59, 6{middle dot}43969E-26), non-smokers (1{middle dot}52, 1{middle dot}16 - 1{middle dot}99, 0{middle dot}02) and non-vegetarianism MESHD (1{middle dot}67, 1{middle dot}41 - 1{middle dot}99, 3{middle dot}03821E-08). An iterative regression analysis was confirmatory and led to only modest changes to estimates. Predilections for sero-positivity was noted with specific ABO blood groups -O was associated with a lower risk. InterpretationIn a first-of-its-kind study from India, we report the sero-positivity in a country-wide cohort and identify variable susceptible associations for contacting infection. Serology and Neutralizing Antibody response provides much-sought-for general insights on the immune response to the virus among Indians and will be an important resource for designing vaccination strategies. FundingCouncil of Scientific and Industrial Research, India (CSIR)

    Impact of SARS-CoV-2 on reperfusion therapies for acute ischemic stroke in Lombardy, Italy. The STROKOVID network

    Authors: Alessandro Pezzini; Mario Grassi; Giorgio Silvestrelli; Martina Locatelli; Nicola Rifino; Simone Beretta; Massimo Gamba; Elisa Raimondi; Giuditta Giussani; Federico Carimati; Davide Sangalli; Manuel Corato; Simonetta Gerevini; Stefano Masciocchi; Matteo Cortinovis; Sara La Gioia; Francesca Barbieri; Valentina Mazzoleni; Debora Pezzini; Sonia Bonacina; Andrea Pilotto; Alberto Benussi; Mauro Magoni; Enrico Premi; Alessandro Cesare Prelle; Elio Clemente Agostoni; Fernando Palluzzi; Valeria De Giuli; Anna Magherini; Daria Valeria Roccatagliata; Luisa Vinciguerra; Valentina Puglisi; Laura Fusi; Rubjona Xhani; Federico Pozzi; Susanna Diamanti; Francesco Santangelo; Giampiero Grampa; Maurizio Versino; Andrea Salmaggi; Simona Marcheselli; Anna Cavallini; Alessia Giossi; Bruno Censori; Carlo Ferrarese; Alfonso Ciccone; Maria Sessa; Alessandro Padovani

    doi:10.21203/rs.3.rs-105649/v1 Date: 2020-11-10 Source: ResearchSquare

    Whether and how SARS-CoV-2 outbreak affected in-hospital acute stroke MESHD care system is still matter of debate. In the setting of the STROKOVID network, a collaborative project between the 10 centers designed as hubs for the treatment of acute stroke MESHD during SARS-CoV-2 outbreak in Lombardy, Italy, we retrospectively compared clinical features and process measures of patients with confirmed infection ( COVID-19 MESHD) and non-infected MESHD patients (non- COVID-19 MESHD) who underwent reperfusion therapies for acute ischemic stroke MESHD. Between March 8 HGNC and April 30, 2020, 296 consecutive patients (median age, 74 [interquartile range (IQR), 62–80.75] years; males, 154 [52.0%]; 34 [11.5%] COVID-19 MESHD) qualified for the analysis. Time from symptoms onset to treatment was longer in the COVID-19 MESHD group (230 [IQR, 200.5–270] minutes vs 190 [IQR, 150–245] minutes; p=0.007), especially in the first half of the study period. Patients with COVID-19 MESHD who underwent endovascular thrombectomy had more frequently absent collaterals or collaterals filling ≤50% of the occluded territory (50.0% vs 16.6%; OR, 5.05; 95% CI, 1.82–13.80) and a lower rate of good/complete recanalization of the primary arterial occlusive lesion MESHD (55.6% vs 81.0%; OR, 0.29; 95% CI, 0.10–0.80). Post-procedural intracranial hemorrhages MESHD were more frequent (35.3% vs 19.5%; OR, 2.24; 95% CI, 1.04-4.83) and outcome was worse among COVID-19 MESHD patients (in-hospital death, 38.2% vs 8.8%; OR, 6.43; 95% CI, 2.85-14.50). Our findings showed longer delays in the intra-hospital management of acute ischemic stroke MESHD in COVID-19 MESHD patients, especially in the early phase of the outbreak, that likely impacted patients outcome and should be the target of future interventions. 

    Cancer Patient Management Strategy in a Cancer Center of Zhejiang, China During the COVID-19 Pandemic MESHD 

    Authors: Song-xiao Xu; Xiang-dong Cheng; Zhi-wen Pan; Qian Song; Yi-hong Wang; Juan Xiong; Yong-yi Chen; Fan Fan; Jing Zhu; Wan-ying Wu; Xue-ying Deng; Yan-pin Yu; Xiao-hong Xu; Wen-hu Chen; Tao Zhu; Yang Yu; Kai-zhong Liu; Guo-liang Shao; Ming Chen; En-yan Yu

    doi:10.21203/rs.3.rs-30259/v4 Date: 2020-05-19 Source: ResearchSquare

    Background: Due to the increased risk of v iral infection MESHDand the severe shortage of medical resources during the pandemic of COVID-19 MESHD, most hospitals in the epidemic areas significantly reduced non-emergency admissions and services, if not closed. As a result, it has been difficult to treat c ancer MESHDpatients on time, which adversely affects their prognosis. To address this problem, c ancer MESHDcenters must develop a strategic plan to manage both inpatients and outpatients during the pandemic, provide them with the necessary treatment, and at the same time prevent the spread of the virus among patients, visitors and medical staff. Methods: Based upon the epidemic situation in Zhejiang Province, China, the number of running non-emergency medical wards in the Zhejiang Cancer Hospital was gradually increased in a controlled manner. All staff of the hospital received COVID-19 MESHD preventive training and was provided with three different levels of protection according to the risks of their services. Only patients without a known history of SARS-CoV-2 contact were eligible to schedule an appointment. Body temperature was measured on all patients upon their arrival at the hospital. Chest CT image, blood cell counting and travel/contact history were investigated in patients with f ever. MESHD Respiratory tract samples, such as sputum and throat swabs, from all patients, including those clinically suspected of SARS-CoV-2 infection MESHD ARS-CoV-2 infection, MESHD were collected for nucleic acid detection of SARS-CoV-2 before treatment.Results: A total of 3697 inpatients and 416 outpatients seeking c ancer MESHDtreatment were enrolled from February 1 to April 3, 2020, in compliance with the hospital’s infection-control interventions. The clinicopathological parameters of the patients were summarized herein. 4237 samples from 4101 patients produced negative RNA testing results. Four clinically suspected patients all presented negative RNA test results and were excluded from the SARS-CoV-2 infection MESHD ARS-CoV-2 infection MESHDthrough follow-up retesting and monitoring. Seven patients with only N-gene PROTEIN positive results were retested, followed by CT scan and SARS-CoV-2 contact history investigation. All of them were finally diagnosed as n on-infected MESHDpatients. There was one outpatient who was confirmed positive by virus RNA test and then followed up. She might be an asymptomatic laboratory-confirmed case. During the study period, there was no SARS-CoV-2 infection MESHD ARS-CoV-2 infection MESHDamong staff, patients and escorts of patients in the Zhejiang Cancer Hospital.Conclusion: This study suggested our infection-control interventions, including viral nucleic acid test, could be used as a reliable method to screen c ancer MESHDpatients in the area with moderate COVID-19 MESHD prevalence. C ancer MESHDmay not be a high-risk factor of SARS-CoV-2 infection MESHD ARS-CoV-2 infection. MESHD 

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HGNC Genes
SARS-CoV-2 Proteins


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