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MeSH Disease

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SARS-CoV-2 proteins

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    Impact of SARS-CoV-2 on Fetal Malformation During Pregnancy: A Case Report of Fetal Autopsy

    Authors: Yuping Guo; Jiacai Ren; Jingping Yuan; Di Lei; Nawsherwan .; Ying Yu; Cuifang Fan; Suqing Wang

    doi:10.21203/rs.3.rs-87715/v1 Date: 2020-10-04 Source: ResearchSquare

    Background: Little is known about the impact of SARS-CoV-2 on fetal anomalies. Case presentation: We described a case report of fetal anomalies MESHD during second-trimester (25+3 weeks) pregnancy. The fetal autopsy was found with abnormal heart anatomy MESHD (including ventricular septal defect MESHD, oval hole valve missing, and pericardial effusion MESHD), polycystic kidney MESHD, and acute chorioamnionitis MESHD. Conclusions: SARS-CoV-2 infection MESHD in second-trimester pregnancy not the direct factor resulted in congenital defects MESHD, and multiple risk factors contribute to these changes.   

    Unusual Presentation of Kawasaki Disease with Multisystem Inflammation and Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2: A Case Report

    Authors: Haena Kim; Jung Yeon Shim; Jae-Hoon Ko; Aram Yang; Jae Won Shim; Deok Soo Kim; Hye Lim Jung; Ji Hee Kwak; In Suk Sol

    doi:10.21203/rs.3.rs-41276/v1 Date: 2020-07-12 Source: ResearchSquare

    Background: Since mid-April 2020, cases of multisystem inflammatory syndrome MESHD in children (MIS-C) associated with coronavirus disease MESHD ( COVID-19 MESHD) that mimic Kawasaki disease MESHD ( KD MESHD) have been reported in Europe and North America. However, no cases have been in East Asia, where KD MESHD is more prevalent.Case presentation: A previously healthy 11-year-old boy was admitted with a 4-day history of fever MESHD and abdominal pain MESHD. He had no contact history to any patient with COVID-19 MESHD. Blood acute inflammatory markers were highly elevated. He was treated with antibiotics for suspected bacterial enteritis MESHD, but he suddenly developed hypotension MESHD. Inotropics and intravenous immunoglobulin were administered to manage septic shock MESHD. On hospitalization day 6, he developed signs and symptoms of KD MESHD (conjunctival injection, strawberry tongue, cracked lip MESHD, and coronary artery dilatation MESHD) in addition to pleural/pericardial effusion MESHD and mesenteric lymphadenitis MESHD. The results of microbiologic tests, including reverse-transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were negative. Fluorescent immunoassay and enzyme-linked immunosorbent assay revealed abundant IgG antibodies against SARS-CoV-2 in his serum, but no IgM antibodies. He was discharged successfully on day 13.Conclusion: MIS-C may occur in children with a previously asymptomatic COVID-19 MESHD infection. A high index of suspicion is required for this novel syndrome in unusual cases of KD MESHD or KD shock syndrome MESHD with multisystem inflammation MESHD, even when there is no clear history of contact or symptoms of COVID-19 MESHD.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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