Corpus overview


Overview

MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

ProteinS (56)

ProteinN (21)

NSP5 (11)

ComplexRdRp (9)

ProteinE (6)


Filter

Genes
Diseases
SARS-CoV-2 Proteins
    displaying 1331 - 1340 records in total 1346
    records per page




    The transmembrane serine protease inhibitors are potential antiviral drugs for 2019-nCoV targeting the insertion sequence-induced viral infectivity enhancement

    Authors: Tong Meng; Hao Cao; Hao Zhang; Zijian Kang; Da Xu; Haiyi Gong; Jing Wang; Zifu Li; Xingang Cui; Huji Xu; Haifeng Wei; Xiuwu Pan; Rongrong Zhu; Jianru Xiao; Wang Zhou; Liming Cheng; Jianmin Liu

    doi:10.1101/2020.02.08.926006 Date: 2020-02-11 Source: bioRxiv

    At the end of 2019, the SARS-CoV-2 induces an ongoing outbreak of pneumonia MESHD in China1, even more spread than SARS-CoV infection2. The entry of SARS-CoV into host cells mainly depends on the cell receptor ( ACE2 HGNC) recognition and spike protein PROTEIN cleavage-induced cell membrane fusion3,4. The spike protein PROTEIN of SARS-CoV-2 also binds to ACE2 HGNC with a similar affinity, whereas its spike protein PROTEIN cleavage remains unclear5,6. Here we show that an insertion sequence in the spike protein PROTEIN of SARS-CoV-2 enhances the cleavage efficiency, and besides pulmonary alveoli MESHD, intestinal and esophagus epithelium were also the target tissues of SARS-CoV-2. Compared with SARS-CoV MESHD, we found a SPRR insertion in the S1/S2 protease cleavage sites of SARS-CoV-2 spike PROTEIN protein increasing the cleavage efficiency by the protein sequence aligment and furin score calculation. Additionally, the insertion sequence facilitates the formation of an extended loop which was more suitable for protease recognition by the homology modeling and molicular docking. Furthermore, the single-cell transcriptomes identified that ACE2 HGNC and TMPRSSs are highly coexpressed in AT2 cells of lung, along with esophageal MESHD upper epithelial cells and absorptive enterocytes. Our results provide the bioinformatics evidence for the increased spike protein PROTEIN cleavage of SARS-CoV-2 and indicate its potential target cells.

    Clinical characteristics of 2019 novel coronavirus infection MESHD in China

    Authors: Wei-jie Guan; Zheng-yi Ni; Yu Hu; Wen-hua Liang; Chun-quan Ou; Jian-xing He; Lei Liu; Hong Shan; Chun-liang Lei; David SC Hui; Bin Du; Lan-juan Li; Guang Zeng; Kowk-Yung Yuen; Ru-chong Chen; Chun-li Tang; Tao Wang; Ping-yan Chen; Jie Xiang; Shi-yue Li; Jin-lin Wang; Zi-jing Liang; Yi-xiang Peng; Li Wei; Yong Liu; Ya-hua Hu; Peng Peng; Jian-ming Wang; Ji-yang Liu; Zhong Chen; Gang Li; Zhi-jian Zheng; Shao-qin Qiu; Jie Luo; Chang-jiang Ye; Shao-yong Zhu; Nan-shan Zhong

    doi:10.1101/2020.02.06.20020974 Date: 2020-02-09 Source: medRxiv

    Background: Since December 2019, acute respiratory disease MESHD ( ARD MESHD ARD HGNC) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought to delineate the clinical characteristics of these cases. Methods: We extracted the data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD HGNC ARD MESHD from 552 hospitals in 31 provinces/provincial municipalities through January 29th, 2020. Results: The median age was 47.0 years, and 41.90% were females. Only 1.18% of patients had a direct contact with wildlife, whereas 31.30% had been to Wuhan and 71.80% had contacted with people from Wuhan. Fever MESHD (87.9%) and cough (67.7%) were the most common symptoms. Diarrhea MESHD is uncommon. The median incubation period was 3.0 days (range, 0 to 24.0 days). On admission, ground-glass opacity was the typical radiological finding on chest computed tomography (50.00%). Significantly more severe cases were diagnosed by symptoms plus reverse-transcriptase polymerase-chain-reaction without abnormal radiological findings than non-severe cases (23.87% vs. 5.20%, P<0.001). Lymphopenia MESHD was observed in 82.1% of patients. 55 patients (5.00%) were admitted to intensive care unit and 15 (1.36%) succumbed. Severe pneumonia MESHD was independently associated with either the admission to intensive care unit, mechanical ventilation, or death MESHD in multivariate competing-risk model (sub-distribution hazards ratio, 9.80; 95% confidence interval, 4.06 to 23.67). Conclusions: The 2019-nCoV epidemic spreads rapidly by human-to-human transmission. Normal radiologic findings are present among some patients with 2019-nCoV infection MESHD. The disease severity (including oxygen saturation, respiratory rate, blood leukocyte/lymphocyte count and chest X-ray/CT manifestations) predict poor clinical outcomes.

    Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein PROTEIN insertions and HIV-1

    Authors: Chengxin Zhang; Wei Zheng; Xiaoqiang Huang; Eric W. Bell; Xiaogen Zhou; Yang Zhang

    id:2002.03173v1 Date: 2020-02-08 Source: arXiv

    As the infection of 2019-nCoV coronavirus is quickly developing into a global pneumonia epidemic MESHD, careful analysis of its transmission and cellular mechanisms is sorely needed. In this report, we re-analyzed the computational approaches and findings presented in two recent manuscripts by Ji et al. (https://doi.org/10.1002/jmv.25682) and by Pradhan et al. (https://doi.org/10.1101/2020.01.30.927871), which concluded that snakes are the intermediate hosts of 2019-nCoV and that the 2019-nCoV spike protein PROTEIN insertions shared a unique similarity to HIV-1. Results from our re-implementation of the analyses, built on larger-scale datasets using state-of-the-art bioinformatics methods and databases, do not support the conclusions proposed by these manuscripts. Based on our analyses and existing data of coronaviruses, we concluded that the intermediate hosts of 2019-nCoV are more likely to be mammals and birds than snakes, and that the "novel insertions" observed in the spike protein PROTEIN are naturally evolved from bat coronaviruses.

    Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein PROTEIN insertions and HIV-1

    Authors: Chengxin Zhang; Wei Zheng; Xiaoqiang Huang; Eric W Bell; Xiaogen Zhou; Yang Zhang

    doi:10.1101/2020.02.04.933135 Date: 2020-02-08 Source: bioRxiv

    As the infection of 2019-nCoV coronavirus is quickly developing into a global pneumonia epidemic MESHD, careful analysis of its transmission and cellular mechanisms is sorely needed. In this report, we re-analyzed the computational approaches and findings presented in two recent manuscripts by Ji et al. (https://doi.org/10.1002/jmv.25682) and by Pradhan et al. (https://doi.org/10.1101/2020.01.30.927871), which concluded that snakes are the intermediate hosts of 2019-nCoV and that the 2019-nCoV spike protein PROTEIN insertions shared a unique similarity to HIV-1. Results from our re-implementation of the analyses, built on larger-scale datasets using state-of-the-art bioinformatics methods and databases, do not support the conclusions proposed by these manuscripts. Based on our analyses and existing data of coronaviruses, we concluded that the intermediate hosts of 2019-nCoV are more likely to be mammals and birds than snakes, and that the "novel insertions" observed in the spike protein PROTEIN are naturally evolved from bat coronaviruses.

    ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

    Authors: Jun Wang; Shanmeizi Zhao; Ming Liu; Zhiyao Zhao; Yiping Xu; Ping Wang; Meng Lin; Yanhui Xu; Bing Huang; Xiaoyu Zuo; Zhanghua Chen; Fan Bai; Jun Cui; Andrew M Lew; Jincun Zhao; Yan Zhang; Haibin Luo; Yuxia Zhang

    doi:10.1101/2020.02.05.20020545 Date: 2020-02-07 Source: medRxiv

    Respiratory disease caused by the 2019 novel coronavirus (2019-nCoV) pneumonia MESHD first emerged in Wuhan, Hubei Province, China, in December 2019 and spread rapidly to other provinces and other countries. Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV MESHD and has been suggested to be also the receptor for 2019-nCoV. Paradoxically, ACE2 expression in the lung protects mice from SARS-CoV spike MESHD spike protein PROTEIN induced lung injury MESHD by attenuating the renin-angiotensin system. In the intestine, ACE2 also suppresses intestinal inflammation MESHD by maintaining amino acid homeostasis, antimicrobial peptide expression and ecology of the gut microbiome. Upon analysis of single cell-RNA sequencing data from control subjects and those with colitis MESHD or inflammatory bowel disease MESHD ( IBD MESHD), we found that ACE2 expression in the colonocytes was positively associated with genes regulating viral infection MESHD, innate and cellular immunity, but was negatively associated with viral transcription, protein translation, humoral immunity, phagocytosis and complement activation. In summary, we suggest that ACE2 may play dual roles in mediating the susceptibility and immunity of 2019-nCoV infection MESHD.

    Using predicted imports of 2019-nCoV cases to determine locations that may not be identifying all imported cases

    Authors: Pablo M De Salazar; Rene Niehus; Aimee Taylor; Caroline O Buckee; Marc Lipsitch

    doi:10.1101/2020.02.04.20020495 Date: 2020-02-05 Source: medRxiv

    Cases from the ongoing outbreak of atypical pneumonia MESHD caused by the 2019 novel coronavirus (2019-nCoV) exported from mainland China can lead to self-sustained outbreaks in other populations. Internationally imported cases are currently being reported in several different locations. Early detection of imported cases is critical for containment of the virus. Based on air travel volume estimates from Wuhan to international destinations and using a generalized linear regression model we identify locations which may potentially have undetected internationally imported cases.

    Population movement, city closure and spatial transmission of the 2019-nCoV infection MESHD in China

    Authors: Siqi Ai; Guanghu Zhu; Fei Tian; Huan Li; Yuan Gao; Yinglin Wu; Qiyong Liu; Hualiang Lin

    doi:10.1101/2020.02.04.20020339 Date: 2020-02-05 Source: medRxiv

    The outbreak of pneumonia MESHD caused by a novel coronavirus (2019-nCoV) in Wuhan City of China obtained global concern, the population outflow from Wuhan has contributed to spatial expansion in other parts of China. We examined the effects of population outflow from Wuhan on the 2019-nCoV transmission in other provinces and cities of China, as well as the impacts of the city closure in Wuhan. We observed a significantly positive association between population movement and the number of cases. Further analysis revealed that if the city closure policy was implemented two days earlier, 1420 (95% CI: 1059, 1833) cases could be prevented, and if two days later, 1462 (95% CI: 1090, 1886) more cases would be possible. Our findings suggest that population movement might be one important trigger of the 2019-nCoV infection MESHD transmission in China, and the policy of city closure is effective to prevent the epidemic.

    The digestive system is a potential route of 2019-nCov infection MESHD: a bioinformatics analysis based on single-cell transcriptomes

    Authors: Hao Zhang; Zijian Kang; Haiyi Gong; Da Xu; Jing Wang; Zifu Li; Xingang Cui; Jianru Xiao; Tong Meng; Wang Zhou; Jianmin Liu; Huji Xu

    doi:10.1101/2020.01.30.927806 Date: 2020-01-31 Source: bioRxiv

    Since December 2019, a newly identified coronavirus (2019 novel coronavirus, 2019-nCov) is causing outbreak of pneumonia MESHD in one of largest cities, Wuhan, in Hubei province of China and has draw significant public health attention. The same as severe acute respiratory syndrome coronavirus (SARS-CoV) MESHD, 2019-nCov enters into host cells via cell receptor angiotensin converting enzyme II (ACE2). In order to dissect the ACE2-expressing cell composition and proportion and explore a potential route of the 2019-nCov infection MESHD in digestive system infection MESHD, 4 datasets with single-cell transcriptomes of lung, esophagus, gastric, ileum and colon MESHD were analyzed. The data showed that ACE2 was not only highly expressed in the lung AT2 cells, esophagus upper and stratified epithelial cells but also in absorptive enterocytes from ileum and colon MESHD. These results indicated along with respiratory systems, digestive system is a potential routes for 2019-nCov infection MESHD. In conclusion, this study has provided the bioinformatics evidence of the potential route for infection of 2019-nCov in digestive system along with respiratory tract and may have significant impact for our healthy policy setting regards to prevention of 2019-nCoV infection MESHD.

    Therapeutic Drugs Targeting 2019-nCoV Main Protease PROTEIN by High-Throughput Screening

    Authors: Yan Li; Jinyong Zhang; Ning Wang; Haibo Li; Yun Shi; Gang Guo; Kaiyun Liu; Hao Zeng; Quanming Zou

    doi:10.1101/2020.01.28.922922 Date: 2020-01-29 Source: bioRxiv

    2019 Novel Coronavirus (2019-nCoV) is a virus identified as the cause of the outbreak of pneumonia MESHD first detected in Wuhan, China. Investigations on the transmissibility, severity, and other features associated with this virus are ongoing. Currently, there is no vaccine or therapeutic antibody to prevent the infection, and more time is required to develop an effective immune strategy against the pathogen. In contrast, specific inhibitors targeting the key protease involved in replication and proliferation of the virus are the most effective means to alleviate the epidemic. The main protease PROTEIN of SARS-CoV MESHD is essential for the life cycle of the virus, which showed 96.1% of similarity with the main proteaseof 2019-nCoV, is considered to be an attractive target for drug development. In this study, we have identified 4 small molecular drugs with high binding capacity with SARS-CoV MESHD main protease PROTEIN by high-throughput screening based on the 8,000 clinical drug libraries, all these drugs have been widely used in clinical applications with guaranteed safety, which may serve as promising candidates to treat the infection of 2019-nCoV.

    Infodemiological Study Using Google Trends on Coronavirus Epidemic in Wuhan, China

    Authors: Artur Strzelecki; Mariia Rizun

    id:2001.11021v3 Date: 2020-01-29 Source: arXiv

    The recent emergence of a new coronavirus ( COVID-19 MESHD) has gained a high cover in public media and worldwide news. The virus has caused a viral pneumonia MESHD in tens of thousands of people in Wuhan, a central city of China. This short paper gives a brief introduction on how the demand for information on this new epidemic is reported through Google Trends. The reported period is 31 December 2020 to 20 March 2020. The authors draw conclusions on current infodemiological data on COVID-19 MESHD using three main search keywords: coronavirus, SARS and MERS. Two approaches are set. First is the worldwide perspective, second - the Chinese one, which reveals that in China this disease in the first days was more often referred to SARS then to general coronaviruses, whereas worldwide, since the beginning, it is more often referred to coronaviruses.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.