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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Airway expression of SARS-CoV-2 receptor, ACE2 HGNC, and proteases, TMPRSS2 HGNC and furin HGNC, in severe asthma

    Authors: Nazanin Kermani; Woo-jung Song; Alan Lunt; Yusef Badi; Ali Versi; Yike GUO; Kai Sun; Pank Bhavsar; Peter Howarth; Sven-Erik Dahlen; Peter Sterk; Ratko Djukanovic; Ian Adcock; Kian Fan Chung

    doi:10.1101/2020.06.29.20142091 Date: 2020-07-03 Source: medRxiv

    Background. Patients with severe asthma MESHD may have a greater risk of dying from COVID-19 MESHD disease caused by SARS-CoV-2 virus. Angiotensin converting enzyme 2 HGNC ( ACE2 HGNC) receptor and enzyme proteases, transmembrane protease, serine 2 HGNC ( TMPRSS2 HGNC) and furin HGNC are needed for the attachment and invasion of the virus into host cells. We determined whether their expression in the airways of severe asthma MESHD patients is increased. Method. We examined the microarray mRNA expression of ACE2 HGNC, TMPRSS2 HGNC and furin HGNC in the sputum, bronchial brush and bronchial biopsies of participants in the European U-BIOPRED cohort. Results. ACE2 HGNC and furin HGNC sputum gene expression was significantly increased in severe non-smoking asthma MESHD compared to mild-moderate asthma MESHD and healthy volunteers. By contrast, TMPRSS2 HGNC expression in bronchial biopsy and bronchial brushings was increased in severe smoking and ex-smoking asthmatics, and so was furin HGNC expression in bronchial brushings. Several clinical parameters including male gender, oral steroid use and nasal polyps MESHD were positively associated with ACE2 HGNC, TMPRSS2 HGNC and furin HGNC expression levels. There was a higher expression of ACE2 HGNC and furin HGNC in the sputum neutrophilic molecular phenotype with inflammasome activation compared to the eosinophilic Type2-high or paucigranulocytic phenotypes. The enrichment score of the IL-13 HGNC-Type2 gene signature was positively correlated with ACE2 HGNC, TMPRSS2 HGNC and furin HGNC levels. Conclusion. These key determinants of virus entry into the lungs may contribute to the poorer outcomes from COVID-19 MESHD disease in patients with severe asthma MESHD.

    COVID-19 MESHD receptor ACE2 HGNC is expressed in human conjunctival tissue, expecially in diseased conjunctival tissue

    Authors: shengjie li Sr.; danhui li; jianchen fang; qiang liu; xinghuai sun; gezhi xu; wenjun cao

    doi:10.1101/2020.05.21.20109652 Date: 2020-05-23 Source: medRxiv

    COVID-19 MESHD virus has currently caused major outbreaks worldwide. ACE2 HGNC is a major cellular-entry receptor for the COVID-19 MESHD virus. Although ACE2 HGNC is known to be expressed in many organs, whether it is expressed by the conjunctival tissue is largely unknown. Human conjunctival tissues from 68 subjects were obtained, which included 10 subjects with conjunctival nevi, 20 subjects with conjunctivitis MESHD, 9 subjects with conjunctival papilloma MESHD, 16 subjects with conjunctival cyst, 7 subjects with conjunctival polyps MESHD, and 6 ocular traumas MESHD as normal subjects. Expression of ACE2 HGNC was evaluated by immunohistochemistry, immunofluorescence, reverse transcriptase-quantitative polymerase chain reaction, and western blot assay. We observed the expression of ACE2 HGNC by conjunctival tissues, expecially in conjunctival epithelial cells. ACE2 HGNC was significantly (p<0.001) overexpressed in conjunctival cells obtained from subjects with conjunctivitis MESHD, conjunctival nevi, conjunctival papilloma MESHD, conjunctival cyst, and conjunctival polyps epithelial cells when compared to that in conjunctival epithelial cells obtained from control subjects. Collectively, clinical features of reported COVID-19 MESHD patients combined with our results indicate that COVID-19 MESHD is likely to be transmitted through the conjunctiva.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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