RationaleSeveral studies have estimated basic production number of novel coronavirus pneumonia MESHD
( NCP PROTEIN
). However, the time-varying transmission dynamics of NCP PROTEIN
during the outbreak remain unclear.
ObjectivesWe aimed to estimate the basic and time-varying transmission dynamics of NCP PROTEIN
across China, and compared them with SARS.
MethodsData on NCP PROTEIN
cases by February 7, 2020 were collected from epidemiological investigations or official websites. Data on severe acute respiratory syndrome (SARS) cases in Guangdong Province, Beijing and Hong Kong during 2002-2003 were also obtained. We estimated the doubling time, basic reproduction number (R0) and time-varying reproduction number (Rt) of NCP PROTEIN
Measurements and main resultsAs of February 7, 2020, 34,598 NCP PROTEIN
cases were identified in China, and daily confirmed cases decreased after February 4. The doubling time of NCP PROTEIN
nationwide was 2.4 days which was shorter than that of SARS in Guangdong (14.3 days), Hong Kong (5.7 days) and Beijing (12.4 days). The R0 of NCP PROTEIN
cases nationwide and in Wuhan were 4.5 and 4.4 respectively, which were higher than R0 of SARS in Guangdong (R0=2.3), Hongkong (R0=2.3), and Beijing (R0=2.6). The Rt for NCP PROTEIN
continuously decreased especially after January 16 nationwide and in Wuhan. The R0 for secondary NCP PROTEIN
cases in Guangdong was 0.6, and the Rt values were less than 1 during the epidemic.
ConclusionsNCP may have a higher transmissibility than SARS, and the efforts of containing the outbreak are effective. However, the efforts are needed to persist in for reducing time-varying reproduction number below one.
At a Glance CommentaryO_ST_ABSScientific Knowledge on the SubjectC_ST_ABSSince December 29, 2019, pneumonia infection with 2019-nCoV, now named as Novel Coronavirus Pneumonia ( NCP PROTEIN
), occurred in Wuhan, Hubei Province, China. The disease has rapidly spread from Wuhan to other areas. As a novel virus, the time-varying transmission dynamics of NCP PROTEIN
remain unclear, and it is also important to compare it with SARS.
What This Study Adds to the FieldWe compared the transmission dynamics of NCP PROTEIN
with SARS, and found that NCP PROTEIN
has a higher transmissibility than SARS. Time-varying production number indicates that rigorous control measures taken by governments are effective across China, and persistent efforts are needed to be taken for reducing instantaneous reproduction number below one.