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SARS-CoV-2 proteins

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    Review of clinical characteristics and laboratory findings of COVID-19 MESHD in children-Systematic review and Meta-analysis

    Authors: Harmeet K Kharoud; Rizwana Asim; Lianne Siegel; Lovepreet Chahal; Gagan Deep Singh

    doi:10.1101/2020.09.23.20200410 Date: 2020-09-25 Source: medRxiv

    OBJECTIVE: To conduct a systematic review and meta-analysis to assess the prevalence of various clinical symptoms and laboratory findings of COVID-19 MESHD in children. METHODS: PubMed, MEDLINE, and SCOPUS databases were searched to include studies conducted between January 1, 2020, and July 15, 2020 which reported data about clinical characteristics and laboratory findings in laboratory-confirmed diagnosis of COVID-19 MESHD in pediatric patients. Random effects meta-analysis using generalized linear mixed models was used to estimate the pooled prevalence. RESULTS: The most prevalent symptom of COVID-19 MESHD in children was 46.17% (95%CI 39.18-53.33%), followed by cough (40.15%, 95%CI 34.56-46.02%). Less common symptoms were found to be dyspnea MESHD, vomiting MESHD, nasal congestion/ rhinorrhea MESHD, diarrhea MESHD, sore throat/pharyngeal congestion, headache MESHD, and fatigue MESHD. The prevalence of asymptomatic children was 17.19% (95%CI 11.02-25.82%). The most prevalent laboratory findings in COVID-19 MESHD children were elevated Creatinine Kinase (26.86%, 95%CI 16.15-41.19%) and neutropenia MESHD (25.76%, 95%CI 13.96-42.58%). These were followed by elevated LDH, thrombocytosis MESHD, lymphocytosis MESHD, neutrophilia, elevated D Dimer, Elevated CRP, elevated ESR, leukocytosis MESHD, elevated AST HGNC and leukopenia MESHD. There was a low prevalence of elevated ALT and lymphopenia MESHD in children with COVID- 19. CONCLUSIONS AND RELEVANCE: This study provides estimates of the pooled prevalence of various symptoms and laboratory findings of COVID-19 MESHD in the pediatric population.

    Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes of 52,251 Patients with Confirmed COVID-19 MESHD Infection: A Systematic Review and Meta-Analysis

    Authors: Ali Pormohammad; Saeed Ghorbani; Behzad Baradaran; Alireza Khatam; Raymond Turner; Mohammad Ali Mansournia; Demetrios N. Kyriacou; Juan-Pablo Idrovo; Nathan C. Bahr

    id:202003.0252/v1 Date: 2020-03-16 Source: Preprints.org

    Introduction: The 2019 novel coronavirus ( COVID-19 MESHD) is very contagious, and can be transmitted to other people by droplet, aerosol, sneezing, infected surface, and cough. There is no vaccine or effective treatment at this time. Therefore, the prevention of COVID-19 MESHD and the rapid diagnosis of infected MESHD patients is crucial. Method: We searched all relevant literature published up to February 28, 2020, from Embase, Scopus, PubMed, Web of Science, and the Cochrane library to collect the studies that reported clinical and laboratory characteristics of COVID-19 MESHD infected MESHD patients. The study quality was assessed with the Critical Appraisal Checklist. Depending on the heterogeneity test, we used either random or fixed-effect models to analyze the appropriateness of the pooled results. Result: Twenty studies were included in the meta-analysis, including a total of 52,251 patients with confirmed COVID-19 MESHD infection. 69.5% (95% CI 54.5-81, p < 0.001) of patients had a history of recent travel to Wuhan, contact with people from Wuhan, or lived in Wuhan. The most common symptoms among COVID-19 MESHD infected MESHD patients were fever MESHD 85.6 % (95% CI 73 -93, p < 0.001), and cough 63 % (95% CI 55.5-70, p < 0.001), respectively. The laboratory analysis showed that thrombocytosis MESHD was present in 91% (95% CI 81-98, p < 0.001) CRP was elevated in 81% (95% CI 65-91, p < 0.001), and lymphopenia MESHD in 62.5% of cases (95% CI 42-79, p < 0.001). The most common radiographic signs were bilateral involvement in 76.8% (95% CI 62.5-87, p < 0.001) and consolidation in 75.5% (95% CI 50.5-91, p < 0.001) of patients. Most patients (85.4%) were hospitalized, 20.6% of patients were admitted to the ICU in critical condition, and the mortality rate was 5.6%. Conclusions: Fever MESHD and cough MESHD are the most common symptoms of COVID-19 MESHD infection in the literature published to date. Thombocytosis, lymphopenia MESHD, and increased CRP were common lab findings although most patients included in the overall analysis did not have laboratory values reported. The most common radiographic sign was bilateral involvement in and consolidation. Among Chinese patients with COVID-19 MESHD, rates of hospitalization, critical condition, and hospitalization were high in this study, but these findings may be biased by reporting only confirmed cases.

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MeSH Disease
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