Corpus overview


MeSH Disease

HGNC Genes

There are no HGNC terms in the subcorpus

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Increased RV:LV Ratio on Chest CT-Angiogram in COVID-19 MESHD is a Marker of Adverse Outcomes

    Authors: Ran Tao; Zuzana Burivalova; Sofia Carolina Masri; Naga Dharmavaram; Aurangzeb Baber; Roderick Deano; Timothy Hess; Ravi Dhingra; James Runo; Nizar Jarjour; Rebecca R Vanderpool; Naomi Chesler; Joanna E Kusmirek; Marlowe Eldridge; Christopher Francois; Farhan Raza

    doi:10.21203/ Date: 2021-02-22 Source: ResearchSquare

    PurposeOur study aimed to use chest CT-angiogram (CTA) to assess if right ventricular (RV) dilation, quantified as an increased RV:LV (left ventricle) ratio, is associated with adverse outcomes in the novel coronavirus ( COVID-19 MESHD) infection.MethodsWe reviewed clinical, laboratory, and chest CTA findings in COVID-19 MESHD patients (n=100), and two control groups: normal subjects (n=10) and subjects with organizing pneumonia MESHD (n=10). On a chest CTA, we measured basal dimensions of the RV and LV in a focused 4-chamber view; and dimensions of pulmonary artery MESHD ( PA MESHD) and aorta (AO) at the PA MESHD bifurcation level. ResultsAmong the COVID-19 MESHD cohort, the mean age (±SD) was 55.1±14.9 years and 55% were female. A higher RV:LV ratio was correlated with adverse outcomes, defined as ICU admission, intubation, or death MESHD. In patients with adverse outcomes, the RV:LV ratio was 1.06±0.10, vs 0.95±0.15 in patients without adverse outcomes. Among the adverse outcomes group, compared to the control subjects with organizing pneumonia MESHD, the lung parenchymal damage MESHD was lower (22.6±9.0 vs 32.7±6.6), yet the RV:LV ratio was higher (1.06±0.14 vs 0.89±0.07). In ROC analysis, RV:LV ratio had an AUC= 0.707 with an optimal cut-off of RV:LV 1.1 as a predictor of adverse outcomes. In a validation cohort (n=25), an RV:LV ≥1.1 as a cut-off predicted adverse outcomes with an odds ratio of 76:1.ConclusionIn COVID-19 MESHD patients, RV:LV ratio ≥1.1 on CTA-chest is correlated with adverse outcomes. RV dilation in COVID-19 MESHD is out of proportion to parenchymal lung damage MESHD, pointing towards a vascular and/or thrombotic injury MESHD in the lungs.

    Role of pulmonary circulation assessment in CT imaging in evaluating the severity and tendency of severe and critical COVID-19 MESHD pneumonia

    Authors: Qiongjie Hu; Yiwen liu; Yueying Pan; Ziyan Sun; Min Xiang; Kaiyan li; Liming Xia; huilan Zhang; Hanxiong Guan

    doi:10.21203/ Date: 2020-05-28 Source: ResearchSquare

    Objective: To investigate the value of changes of pulmonary circulation in CT imaging in evaluating the severity and tendency of 2019 novel coronavirus disease MESHD ( COVID-19 MESHD) pneumonia MESHD.Methods: This retrospective study analyzed 99 severe and critical COVID-19 MESHD pneumonia MESHD patients including the 47 improved cases and 52 dead cases. Demographic data, laboratory findings, comorbidities, and CT imaging features including the diameters of pulmonary vein (PV), pulmonary artery MESHD ( PA MESHD) and ascending aorta were collected and assessed.Results: The PV diameters of the deceased patients were larger than recovered patients in the severe phase. Compared with the severe phase in the improvement group, the diameters of the pulmonary veins during the improved phase were smaller, and the total CT scores were significantly decreased (p < 0.001). Instead, there was no significant difference in the ratio of main PA MESHD to aorta diameter between the recovered group and the deceased group, nor did the self control of the recovered group and the deceased group (p > 0.05). Construction of a ROC curve yielded an optimal cut-off value of the PV diameters for prediction of survival (p < 0.05).Conclusion: The changes of the PV diameters might indirectly reflect the activity of pulmonary inflammation MESHD and cardiac insufficiency MESHD. Pulmonary manifestations of severe and critical COVID-19 MESHD pneumonia MESHD might be related to myocardial injury MESHD and cardiac insufficiency MESHD, expecially accompanied by dilated PVs. Evaluation of changes in pulmonary circulation by chest CT images may be considered as a useful tool for determining the severity, fatal outcome and tendency of COVID-19 MESHD.Key words: COVID-19 MESHD, pneumonia MESHD, pulmonary circulation MESHD, Computed Tomography

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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