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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

ProteinS (15)

ProteinN (6)

NSP5 (4)

ProteinS1 (3)

NSP3 (2)


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    Clinical Characteristics of SARS-CoV-2 Pneumonia Compared to Controls in Chinese Han Population

    Authors: Yang Xu; Yi-rong Li; Qiang Zeng; Zhi-bing Lu; Yong-zhe Li; Wei Wu; Sheng-yong Dong; Gang Huang; Xing-huan Wang

    doi:10.1101/2020.03.08.20031658 Date: 2020-03-10 Source: medRxiv

    Background In December 2019, novel coronavirus (SARS-CoV-2) infected pneumonia MESHD occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of SARS-CoV-2 pneumonia MESHD without comorbidities compared to normal controls in Chinese Han population is limited. Our objective is to describe the epidemiological and clinical characteristics of SARS-CoV-2 pneumonia MESHD without comorbidities compared to normal controls in the Chinese Han population. Methods Retrospective, multi-center case series of the 69 consecutive hospitalized patients with confirmed SARS-CoV-2 pneumonia MESHD, from February 7 to February 28, 2020; final date of follow-up was February 29, 2020. Results The study population included 69 hospitalized patients with confirmed SARS-CoV-2 pneumonia MESHD without comorbidities and 14,117 normal controls. 50.7% patients were male and 49.3% were female; 1.5% patients were asymptomatic cases, 63.8% patients were mild cases, and 36.2% patients were severe or critical cases. Compared with mild patients (n = 44), severe or critical patients (n = 25) were significantly older (median age, 67 years [IQR, 58-79] vs. 49 years [IQR, 36-60]; P < 0.01). Fever MESHD was present in 98.6% of the patients. The second most common symptom was cough (62.3%), fatigue MESHD (58.0%), sputum (39.1%), and headache MESHD (33.3%). The median incubation period was 4 days (IQR, 2 to 7). Leukocyte count was 74.1% of normal controls and lymphocyte count was 45.9% of normal controls. The phenomenon of lymphocyte depletion ( PLD HGNC) observed in severe or critical cases in 100%. Levels of lactate dehydrogenase, D-dimer, procalcitonin, and interleukin-6 HGNC were showed significant differences between mild and severe or critical cases. Chest computed tomographic scans showed bilateral patchy patterns (49.3%), local patchy shadowing (29.0%), and ground glass opacity (21.7%). 7.3% patients were diagnosed ARDS, 7.3% patients were diagnosed acute cardiac injury MESHD (troponin I >28 pg/mL) and 4.4% patients were diagnosed fungal infections MESHD or shock MESHD. 4.3% patients have been discharged; 1.5% patient had died; 1.5% patient had recovery. Conclusions In this multicenter case series of 69 patients without comorbidities, the full spectrum of asymptomatic, mild, severe, and critical cases is described. 50.7% patients were male and 49.3% were female; 1.5% patients were asymptomatic cases, 63.8% patients were mild cases, and 36.2% patients were severe or critical cases. 4.3% patients have been discharged; 1.5% patient had died; 1.5% patient had recovery. Among the 25 patients with severe or critical disease MESHD, 12.0% patients were underwent non-invasive mechanical ventilation, 8.0% patients underwent invasive mechanical ventilation, and 4.0% patients died.

    The potential role of IL-6 HGNC in monitoring coronavirus disease 2019 MESHD.

    Authors: Tao Liu; Jieying Zhang; Yuhui Yang; Hong Ma; Zhengyu Li; Jiaoyue Zhang; Ji Cheng; Xiaoyun Zhang; Yanxia Zhao; Zihan Xia; Liling Zhang; Gang Wu; Jianhua Yi

    doi:10.1101/2020.03.01.20029769 Date: 2020-03-06 Source: medRxiv

    Abstract. Background: The outbreak of coronavirus disease 2019 MESHD ( COVID-19 MESHD) in Wuhan City, China spreads rapidly since December, 2019. Most patients show mild symptoms, but some of them develop into severe disease. There is currently no specific medication. The purpose of this study is to to explore changes of markers in peripheral blood of severe COVID-19 MESHD patients, which may be of value in disease monitoring. Methods Clinical data of patients with nonsevere and severe type COVID-19 MESHD diagnosed by laboratory test in our institution were collected. The relationship between peripheral blood cells and cytokines, clinical manifestation and outcome was analyzed. Results A total of 69 severe type COVID-19 MESHD patients were included. On admission, the median age of severe cases was 56-year old, with 52.17% female patient. The most common symptoms were fever MESHD (79.72%), cough (63.77%), shortness of breath MESHD (57.97%) and fatigue MESHD (50.72%). Diarrhea MESHD is less common. The most common comorbidity is hypertension MESHD. Upon admission, the proportion of bilateral pulmonary involvement and interstitial abnormalities MESHD evidenced by chest computed tomography (CT) imaging in severe cases was 60.87% and 27.54%, respectively. Compared with patients with nonsevere disease, those with severe disease showed obvious lymphocytopenia MESHD. Elevated level of lactate dehydrogenase (LDH), C-reactive protein (CRP) HGNC, ferritin and D-dimer was found in most cases. Two patients (2.9%) needed transfer to the intensive care unit. Baseline immunological parameters and most of the inflammatory parameters were basically within the normal range. However, baseline interleukin-6 HGNC ( IL-6 HGNC) was significantly increased in severe type, which was closely related to the maximal body temperature during hospitalization and to CT findings. Baseline IL-6 HGNC was also significantly related to the increase of baseline level of CRP HGNC, LDH, ferritin and D-dimer. The increase of baseline IL-6 HGNC level suggests that it may positively correlate with the severity of COVID-19 MESHD. Among the 30 severe type patients whose IL-6 HGNC was assessed before and after treatment, significant decrease in IL-6 HGNC and improved CT assessment was found in 25 patients after treatment. Whereas the IL-6 HGNC level was further increased in 3 cases, which was closely related to disease progression. It is suggested that IL-6 HGNC may be used as a marker for disease monitoring in severe COVID-19 MESHD patients. Conclusions On admission, the baseline level of IL-6 HGNC, CRP HGNC, LDH and ferritin was closely related to the severity of COVID-19 MESHD, and the elevated IL-6 HGNC was significantly related to the clinical manifestation of severe type patients. The decrease of IL-6 HGNC was closely related to treatment effectiveness, while the increase of IL-6 HGNC indicated disease exacerbation. Collectively, the dynamic change of IL-6 HGNC level can be used as a marker for disease monitoring in patients with severe COVID-19 MESHD.

    Clinical and Laboratory Profiles of 75 Hospitalized Patients with Novel Coronavirus Disease 2019 MESHD in Hefei, China

    Authors: Zonghao Zhao; Jiajia Xie; Ming Yin; Yun Yang; Hongliang He; Tengchuan Jin; Wenting Li; Xiaowu Zhu; Jing Xu; Changcheng Zhao; Lei Li; Yi Li; Hylemariam Mihiretie Mengist; Ayesha Zahid; Ziqin Yao; Chengchao Ding; Yingjie Qi; Yong Gao; Xiaoling Ma

    doi:10.1101/2020.03.01.20029785 Date: 2020-03-06 Source: medRxiv

    The outbreak of the novel coronavirus disease 2019 MESHD ( COVID-19 MESHD) infection began in December 2019 in Wuhan, and rapidly spread to many provinces in China. The number of cases has increased markedly in Anhui, but information on the clinical characteristics of patients is limited. We reported 75 patients with COVID-19 MESHD in the First Affiliated Hospital of USTC from Jan 21 to Feb 16, 2020, Hefei, Anhui Province, China. COVID-19 MESHD infection was confirmed by real-time RT-PCR of respiratory nasopharyngeal swab samples. Epidemiological, clinical and laboratory data were collected and analyzed. Of the 75 patients with COVID-19 MESHD, 61 (81.33%) had a direct or indirect exposure history to Wuhan. Common symptoms at onset included fever MESHD (66 [88.0%] of 75 patients) and dry cough MESHD (62 [82.67%]). Of the patients without fever MESHD, cough MESHD could be the only or primary symptom. The most prominent laboratory abnormalities were lymphopenia MESHD, decreased percentage of lymphocytes (LYM%), decreased CD4+ and CD8+ T cell counts, elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH). Patients with elevated interleukin 6 ( IL-6 HGNC) showed significant decreases in the LYM%, CD4+ and CD8+ T cell counts. Besides, the percentage of neutrophils, CRP HGNC, LDH and Procalcitonin levels increased significantly. We concluded that COVID-19 MESHD could cause different degrees of hematological abnormalities MESHD and damage of internal organs. Hematological profiles including LYM, LDH, CRP HGNC and IL-6 HGNC could be indicators of diseases severity and evaluation of treatment effectiveness. Antiviral treatment requires a comprehensive and supportive approach. Further targeted therapy should be determined based on individual clinical manifestations and laboratory indicators.

    The correlation Between Viral Clearance and Biochemical Outcomes of 94 Discharged Patients with COVID-19 MESHD Infection

    Authors: Jing Yuan; Rongrong Zou; Lijiao Zeng; Shanglong Kou; Jianfeng Lan; Xiaohe Li; Yanhua Liang; Xiaoyan Din; Guoyu Tan; Shenghong Tang; Lei Liu; Yingxia Liu; Yanchao Pan; Zhaoqin Wang

    doi:10.21203/rs.3.rs-16554/v1 Date: 2020-03-05 Source: ResearchSquare

    Objective  This study aims to evaluate the relationships between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 MESHD infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020.Methods  The clinical, and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical symptoms and signs, medical treatment, virus clearance and laboratory parameters including interleukin 6 ( IL-6 HGNC) and C-reactive protein HGNC ( CRP HGNC) were collected.Results   COVID-19 MESHD mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 MESHD mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir+ ribavirin.Conclusions  Therapeutic regimen of IFN-α+lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin regimens might be beneficial for treatment of COVID-19 MESHD. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 MESHD infection.

    Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 HGNC ( IL-6 HGNC) level in critically ill COVID-19 MESHD patients

    Authors: Xiaohua Chen; Binghong Zhao; Yueming Qu; Yurou Chen; Jie Xiong; Yong Feng; Dong Men; Qianchuan Huang; Ying Liu; Bo Yang; Jinya Ding; Feng Li

    doi:10.1101/2020.02.29.20029520 Date: 2020-03-03 Source: medRxiv

    Background: Although the SARS-CoV-2 viral load detection of respiratory specimen has been widely used for novel coronavirus disease MESHD ( COVID-19 MESHD) diagnosis, it is undeniable that serum SARS-CoV-2 nucleic acid (RNAaemia) could be detected in a fraction of the COVID-19 MESHD patients. However, it is not clear that if the incidence of RNAaemia could be correlated with the occurrence of cytokine storm or with the specific class of patients. Methods: This study enrolled 48 patients with COVID-19 MESHD admitted to the General Hospital of Central Theater Command, PLA, a designated hospital in Wuhan, China. The patients were divided into three groups according to the Diagnosis and Treatment of New Coronavirus Pneumonia (version 6) published by the National Health Commission of China. The clinical and laboratory data were collected. The serum viral load detection and serum IL-6 HGNC levels were determined. Except for routine statistical analysis, Generalized Linear Models (GLMs) analysis was used to establish a patient status prediction model based on real-time RT-PCR Ct value. Findings: The Result showed that cases with RNAaemia were exclusively confirmed in critically ill MESHD patients group and appeared to reflect the illness severity. Further more, the inflammatory cytokine IL-6 HGNC levels were significantly elevated in critically ill patients, which is almost 10-folds higher than those in other patients. More importantly, the extremely high IL-6 HGNC level was closely correlated with the incidence of RNAaemia (R=0.902) and the vital signs of COVID-19 MESHD patients (R= -0.682). Interpretation: Serum SARS-CoV-2 viral load (RNAaemia) is strongly associated with cytokine storm and can be used to predict the poor prognosis of COVID-19 MESHD patients. Moreover, our results strongly suggest that cytokine IL-6 HGNC should be considered as a therapeutic target in critically ill MESHD patients with excessive inflammatory response.

    Epidemiological and clinical features of COVID-19 MESHD patients with and without pneumonia in Beijing, China

    Authors: Penghui Yang; Yibo Ding; Zhe Xu; Rui Pu; Ping Li; Jin Yan; Jiluo Liu; Fanping Meng; Lei Huang; Lei Shi; Tianjun Jiang; Enqiang Qin; Min Zhao; Dawei Zhang; Peng Zhao; Lingxiang Yu; Zhaohai Wang; Zhixian Hong; Zhaohui Xiao; Qing Xi; Dexi Zhao; Peng Yu; Caizhong Zhu; Zhu Chen; Shaogeng Zhang; Junsheng Ji; Guangwen Cao; Fusheng Wang

    doi:10.1101/2020.02.28.20028068 Date: 2020-03-03 Source: medRxiv

    Background:SARS-CoV-2-caused coronavirus disease MESHD ( COVID-19 MESHD) is posinga large casualty. The features of COVID-19 MESHDpatients withand without pneumonia MESHD,SARS-CoV-2 transmissibility in asymptomatic carriers, and factors predicting disease progression remain unknown. Methods: We collected information on clinical characteristics, exposure history, andlaboratory examinations of all laboratory-confirmed COVID-19 MESHD patients admitted to PLA General Hospital. Cox regression analysis was applied to identify prognostic factors. The last follow-up was February 18, 2020. Results:We characterized 55 consecutive COVID-19 MESHD patients. The mean incubation was 8.42(95% confidence interval [CI], 6.55-10.29) days. The mean SARS-CoV-2-positive duration from first positive test to clearance was 9.71(95%CI, 8.21-11.22) days. COVID-19 MESHD course was approximately 2 weeks. Asymptomatic carriers might transmit SARS-CoV-2. Compared with patients without pneumonia MESHD, those with pneumonia MESHD were 15 years older and had a higher rate of hypertension MESHD, higher frequencies of having a fever MESHD and cough MESHD, and higher levels of interleukin-6 HGNC (14.61 vs. 8.06pg/mL, P=0.040), B lymphocyte proportion (13.0% vs.10.0%, P=0.024), low account (<190/L) of CD8+ T cells (33.3% vs. 0, P=0.019). Multivariate Cox regression analysis indicated that circulating interleukin-6 HGNC andlactate independently predicted COVID-19 MESHD progression, with a hazard ratio (95%CI) of 1.052 (1.000-1.107) and 1.082 (1.013-1.155), respectively. During disease course,T lymphocytes were generally lower,neutrophils higher, in pneumonia MESHD patients than in pneumonia-free MESHD patients. CD8+ lymphocytes did not increase at the 20th days after illness onset. Conclusion: The epidemiological features areimportant for COVID-19 MESHD prophylaxis. Circulating interleukin-6 HGNC and lactateare independent prognostic factors. CD8+ T cell exhaustion might be critical in the development of COVID-19 MESHD.

    Epidemiological and clinical features of 2019-nCoV acute respiratory disease cases in Chongqing municipality, China: a retrospective, descriptive, multiple-center study

    Authors: Di Qi; Xiaofeng Yan; Xumao Tang; Junnan Peng; Qian Yu; Longhua Feng; Guodan Yuan; An Zhang; Yaokai Chen; Jing Yuan; Xia Huang; Xianxiang Zhang; Peng Hu; Yuyan Song; Chunfang Qian; Qiangzhong Sun; Daoxin Wang; Jin Tong; Jianglin Xiang

    doi:10.1101/2020.03.01.20029397 Date: 2020-03-03 Source: medRxiv

    BackgroundIn January 19, 2020, first case of 2019 novel coronavirus (2019-nCoV) pneumonia ( COVID-19 MESHD) was confirmed in Chongqing municipality, China. MethodsIn this retrospective, descriptive, multiple-center study, total of 267 patients with COVID-19 MESHD confirmed by real-time RT-PCR in Chongqing from Jan 19 to Feb 16, 2020 were recruited. Epidemiological, demographic, clinical, radiological characteristics, laboratory examinations, and treatment regimens were collected on admission. Clinical outcomes were followed up until Feb 16, 2020. Results267 laboratory-confirmed COVID-19 MESHD patients admitted to 3 designated-hospitals in Chongqing provincial municipality from January 19 to February 16, 2020 were enrolled and categorized on admission. 217 (81.27%) and 50 (18.73%) patients were categorized into non-severe and severe subgroups, respectively. The median age of patients was 48.0 years (IQR, 35.0-65.0), with 129 (48.3%) of the patients were more than 50 years of age. 149 (55.8%) patients were men. Severe patients were significantly older (median age, 71.5 years [IQR, 65.8-77.0] vs 43.0 years [IQR, 32.5-57.0]) and more likely to be male (110 [50.7%] vs 39 [78.0%]) and have coexisting disorders (15 [30.0%] vs 26 [12.0%]). 41 (15.4%) patients had a recent travel to Hubei province, and 139 (52.1%) patients had a history of contact with patients from Hubei. On admission, the most common symptoms of COVID-19 MESHD were fever 225(84.3%), fatigue (208 [77.9%]), dry cough (189 [70.8%]), myalgia or arthralgia (136 [50.9%]). Severe patients were more likely to present dyspnea (17 [34.0%] vs 26 [12.0%]) and confusion (10 [20.0%] vs 15 [6.9%]). Rales (32 [12.0%]) and wheezes (20 [7.5%]) are not common noted for COVID-19 MESHD patients, especially for the non-severe (11 [5.1%], 10 [4.6%]). 118 (44.2%). Most severe patients demonstrated more laboratory abnormalities. 231 (86.5%), 61 (22.8%) patients had lymphopenia, leukopenia and thrombocytopenia, respectively. CD4+T cell counts decrease was observed in 77.1 % of cases, especially in the severe patients (45, 100%). 53.1% patients had decreased CD+3 T cell counts, count of CD8+T cells was lower than the normal range in part of patients (34.4%). More severe patients had lower level of CD4+ T cells and CD+3 T cells (45 [100.0%] vs 29[56.9%], 31 [68.9%] vs 20 [39.2%]). Most patients had normal level of IL-2 HGNC, IL-4 HGNC, TNF HGNC- and INF-{gamma}, while high level of IL-6 HGNC and IL-17A HGNC was common in COVID-19 MESHD patients (47 [70.1%], 35 [52.2%]). Level of IL-6 HGNC, IL-17A HGNC and TNF HGNC- was remarkably elevated in severe patients (32 [84.2%] vs 15 [51.7%], 25 [65.8%] vs 10 [34.5%], 17 [44.7%] vs 5 [17.2%]). All patients received antiviral therapy (267, 100%). A portion of severe patients (38, 76.0%) received systemic corticosteroid therapy. Invasive mechanical ventilation in prone position, non-invasive mechanical ventilation, high-flow nasal cannula oxygen therapy was adopted only in severe patients with respiratory failure (5[10.0%], 35[70.0%], 12[24.0%]). Traditional Chinese medicine was adopted to most of severe patients (43,86.0%). Conclusion:Our study firstly demonstrated the regional disparity of COVID-19 MESHD in Chongqing municipality and further thoroughly compared the differences between severe and non-severe patients. The 28-day mortality of COVID-19 MESHD patients from 3 designed hospitals of Chongqing is 1.5%, lower than that of Hubei province and mainland China including Hubei province. However, the 28-mortality of severe patients was relatively high, with much higher when complications occurred. Notably, the 28-mortality of critically severe patients complicated with severe ARDS is considerably as high as 44.4%. Therefore, early diagnosis and intensive care of critically severe COVID-19 MESHD cases, especially those combined with ARDS, will be considerably essential to reduce mortality.

    Clinical features of critically ill patients with COVID-19 MESHD infection in China

    Authors: Bo Hu; Dawei Wang; Chang Hu; Ming Hu; Fangfang Zhu; Hui Xiang; Beilei Zhao; Xiaoyi Zhang; Kianoush B. Kashani; Zhiyong Peng

    doi:10.21203/rs.3.rs-16250/v1 Date: 2020-03-02 Source: ResearchSquare

    Importance: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections MESHD outbreak in China is now a global issue. There is only a limited understanding of the clinical characteristics of patients with SARS-CoV-2 infection MESHD SARS-CoV-2 infection MESHDs is available.Objective:To describe the characteristics, management strategies, and outcomes of critically ill MESHD patients with SARS-CoV-2 infection MESHD.Design, Setting, and Patients: This is aretrospective, multi-center case series of 50 critically ill MESHD patients with confirmed SARS-CoV-2 infection MESHD who were admitted at Zhongnan Hospital of Wuhan University and Wuhan Pulmonary Hospital in Wuhan, China, from January 8 to February 9, 2020.Exposures:Documented Corona Virus Disease MESHD, 2019 ( COVID-19 MESHD).Main Outcome Measures: Demographic, clinical, laboratory, imaging data were collected along with management strategies, complications and outcomes of enrolled individuals. Results Fifty critically ill MESHD patients with SARS-CoV-2 infections MESHD were enrolled. Their median age was 62 (range, 29-92) [IQR,49.5-69.0] years, 68% were male, and 28 (56%) patients had comorbidities, the most common being hypertension MESHD. In this cohort, 20(40%) patients survived ,16(32%) patients died, and the rest remained hospitalized. The invasive mechanical ventilator was used in 36(72%) patients with 15(30%) of them requiring prone positioning, and 17(34%) switched to ECMO. The compliance scores of lungs (Cstat)on the day of ICU admission among survivors were higher than those in non-survivors [42.0(18.0-47.0), vs. 19.5(14.0-24.2), p=0.038].The blood IL-6 HGNC levels and neutrophils counts at the first day of ICU admission were significantly higher in non-survivors compared to survivors [123.7(85.3-228.8), vs. 20.2(6.8-67.2) ng/ml, p=0.025 for IL-6 HGNC, and 20.2(6.8-67.2) vs. 4.01(1.99-7.05) × 10⁹/L, p=0.02 for neutrophils counts].The heart rates, PaCO2, lung injury MESHD scale (LIS), and positive end-expiratory pressure levels were constantly higher for 10 days in non-survivors than those who survived (p<0.05). The frequency of vasopressor uses and neuromuscular blockers was higher in non-survivors from day 1 to day 10 compared to survivors (p<0.05). In the whole cohort, the most common complications were ARDS (97%), shock MESHD (44%), arrhythmia MESHD (38%), acute cardiac injury MESHD (26%), and acute kidney injury MESHD (22%). A secondary bacterial infection MESHD was noted in 17(34%) patients. Univariate analysis indicated that lower lung complianceand higher neutrophil counts at the day of ICU admission were related to higher mortality (p-0.03, and 0.04, respectively)ConclusionWe demonstrated that SARS-CoV-2 infection MESHD-related critical illness predominantly affected old individuals with comorbidities and characterized by severe hypoxemic respiratory failure MESHD, often requiring prolonged mechanical ventilation and rescue therapies. Low lung compliance and persistently elevated PaCO2 indicated poor outcomes.

    Clinical Characteristics of 6 patients with SARS-Cov-2 infected severe pneumonia in Zunyi, China

    Authors: Bao Fu; Kun Qian; Tao Chen; Xiaoyun Fu; Miao Chen

    doi:10.21203/rs.3.rs-16200/v1 Date: 2020-03-02 Source: ResearchSquare

    Purpose To study the clinical characteristics, laboratory examination, radiological changes and treatments of 6 patients with severe SARS-Cov-2 infected pneumonia MESHD in Zunyi City, China.MethodsThe clinical data, laboratory examination, radiological changes and clinical treatment process of 6 patients with severe SARS-Cov-2 infected pneumonia MESHD admitted to the Department of Critical Medicine of the Affiliated Hospital of Zunyi Medical University were retrospectively analyzed.Results Four of the six patients were older than 65 years. Two patients had a history of exposure to Wuhan, and four patients had family clustering infection. The most common symptoms at onset of illness were dry cough MESHD (4, 66%) and fever MESHD (4, 66%). Laboratory tests showed that white blood cell count, neutrophil count, C-reactive protein HGNC, IL-6 HGNC, IL-10 HGNC, and urea nitrogen elevated. The Total lymphocyte count and T lymphocyte count decreased. All patients received antiviral therapy, blood purification, immunomodulatory therapy, and Chinese herb treatments. One patient was discharged from the hospital, and 5 patients' condition improved significantly. ConclusionT lymphocyte decreased significantly, IL-6 HGNC and IL-10 HGNC elevated in severe SARS-Cov-2 infected pneumonia MESHD patients. Elderly patients with comorbidities appear to be more severe and to recover more slowly. Blood purification can be tried for severe and critically ill MESHD patients. Early identification and timely treatment of critical cases is of crucial importance. 

    Heart injury signs are associated with higher and earlier mortality in coronavirus disease 2019 MESHD ( COVID-19 MESHD)

    Authors: Chaomin Wu; Xianglin Hu; Jianxin Song; Chunling Du; Jie Xu; Dong Yang; Dechang Chen; Ming Zhong; Jinjun Jiang; Weining Xiong; Ke Lang; Yuye Zhang; Guohua Shi; Lei Xu; Yuanlin Song; Xin Zhou; Ming Wei; Junhua Zheng

    doi:10.1101/2020.02.26.20028589 Date: 2020-02-29 Source: medRxiv

    Importance: Heart injury MESHD can be easily induced by viral infection MESHD such as adenovirus and enterovirus. However, whether coronavirus disease 2019 MESHD ( COVID-19 MESHD) causes heart injury MESHD and hereby impacts mortality has not yet been fully evaluated. Objective: To explore whether heart injury MESHD occurs in COVID-19 MESHD on admission and hereby aggravates mortality later. Design, Setting, and Participants A single-center retrospective cohort study including 188 COVID-19 MESHD patients admitted from December 25, 2019 to January 27, 2020 in Wuhan Jinyintan Hospital, China; follow up was completed on February 11, 2020. Exposures: High levels of heart injury MESHD indicators on admission (hs-TNI; CK; CK-MB; LDH; -HBDH). Main Outcomes and Measures: Mortality in hospital and days from admission to mortality (survival days). Results: Of 188 patients with COVID-19 MESHD, the mean age was 51.9 years (standard deviation: 14.26; range: 21~83 years) and 119 (63.3%) were male. Increased hs-TnI levels on admission tended to occur in older patients and patients with comorbidity (especially hypertension MESHD). High hs-TnI on admission ([≥] 6.126 pg/mL), even within the clinical normal range (0~28 pg/mL), already can be associated with higher mortality. High hs-TnI was associated with increased inflammatory levels (neutrophils, IL-6 HGNC, CRP, and PCT) and decreased immune levels (lymphocytes, monocytes, and CD4+ and CD8+ T cells). CK was not associated with mortality. Increased CK-MB levels tended to occur in male patients and patients with current smoking. High CK-MB on admission was associated with higher mortality. High CK-MB was associated with increased inflammatory levels and decreased lymphocytes. Increased LDH and -HBDH levels tended to occur in older patients and patients with hypertension MESHD. Both high LDH and -HBDH on admission were associated with higher mortality. Both high LDH and -HBDH were associated with increased inflammatory levels and decreased immune levels. hs-TNI level on admission was negatively correlated with survival days (r= -0.42, 95% CI= -0.64~-0.12, P=0.005). LDH level on admission was negatively correlated with survival days (r= -0.35, 95% CI= -0.59~-0.05, P=0.022). Conclusions and Relevance: Heart injury MESHD signs arise in COVID-19 MESHD, especially in older patients, patients with hypertension MESHD and male patients with current smoking. COVID-19 MESHD virus might attack heart via inducing inflammatory storm. High levels of heart injury MESHD indicators on admission are associated with higher mortality and shorter survival days. COVID-19 MESHD patients with signs of heart injury MESHD on admission must be early identified and carefully managed by cardiologists, because COVID-19 MESHD is never just confined to respiratory injury MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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