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SARS-CoV-2 proteins

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    Mortality of Diabetes MESHD-related Acute Metabolic Emergencies MESHD in COVID-19 MESHD patients: a systematic review and meta-analysis

    Authors: Vasileios Periklis Papadopoulos; Peny Avramidou; Stefania-Aspasia Bakola; Dimitra-Georgia Zikoudi; Ntilara Touzlatzi; Marios-Vasileios Koutroulos; Dimitrios K Filippou

    doi:10.1101/2021.01.12.21249697 Date: 2021-01-15 Source: medRxiv

    PurposeLittle is known on the mortality rate in COVID-19 MESHD related acute metabolic emergencies, namely diabetic ketoacidosis MESHD ( DKA MESHD), hyperglycaemic hyperosmolar MESHD state (HHS), combined DKA MESHD/HHS, and euglycaemic diabetic ketoacidosis MESHD ( EDKA MESHD). MethodsA systematic literature review was conducted using EMBASE, PubMed/Medline, and Google Scholar from January 1, 2020 to January 9, 2021 to identify all case report series, cross-sectional studies, and meta-analyses of case reports describing mortality rate in DKA MESHD, HHS, and EDKA MESHD, in COVID-19 MESHD patients. The Joanna Briggs Institute critical appraisal checklist for case reports was used for quality assessment. ResultsFrom 313 identified publications, 4 fulfilled the inclusion criteria and analyzed qualitatively and quantitatively. A systematic review and meta-analysis with subgroup analyses examined mortality rate in a total of 152 COVID-19 MESHD patients who had developed DKA MESHD, HHS, combined DKA MESHD/HHS, or EDKA MESHD. Combined mortality rate and confidence intervals (CI) were estimated using random effects model. The study was registered to PROSPERO database (ID: 230737). ResultsCombined mortality rate was found to be 27.1% [95% CI: 11.2-46.9%]. Heterogeneity was considerable (I2=83%; 95% CI: 56-93%), corrected to 67% according to Von Hippel MESHD adjustment for small meta-analyses. Funnel plot presented no apparent asymmetry; Eggers and Beggs test yielded in P=0.44 and P=0.50, respectively. Sensitivity analysis failed to explain heterogeneity. Conclusion COVID-19 MESHD related acute metabolic emergencies ( DKA MESHD, HHS, and EDKA MESHD) are characterized by considerable mortality; thus, clinicians should be aware of timely detection and immediate treatment commencing.

    Effective treatment with Tocilizumab in a COVID-19 MESHD patient on maintenance hemodialysis: A case report

    Authors: Nicole Nourié; Mohamed Ammar Chamaa; Sarah Mouawad; Micheline Mia Koteit; Serge Finianos; Hiba Azar; Dania Chelala

    doi:10.21203/rs.3.rs-68030/v1 Date: 2020-08-28 Source: ResearchSquare

    Background: Coronavirus disease 2019 MESHD ( COVID-19 MESHD) is a rapidly spreading infective disease MESHD caused by the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2). The management of this disease remains a challenge particularly in certain subgroups of patients such in hemodialysis patients who have higher exposure rates due to the nature of their in-hospital care, and higher mortality due to their burden of comorbidities. Moreover, molecules used in the general population to treat COVID-19 MESHD lack data regarding their pharmacodynamics in the hemodialysis population.Case presentation: We report a case of a 52-year-old patient with Von Hippel Lindau syndrome MESHD and end stage renal disease MESHD on hemodialysis who contracted COVID-19 MESHD infection. Due to the patient’s rapidly deteriorating clinical status he was successfully treated with Tocilizumab, despite the lack of data concerning the use of this molecule in this population. The patient was later discharged after a long hospital stay and progressive clinical, biological and radiological improvement.Conclusion: This sub group of patients should be carefully approached due to the unique nature of their comorbidities, and to their immune’s system response to the virus itself and to novel therapies. Although few studies were available regarding the use of Tocilizumab in the dialysis population, its use proved to be effective and well tolerated in our patient.

    Organization of Primary Health Care in pandemics: a rapid systematic review of the literature in times of COVID-19 MESHD

    Authors: Thiago Dias Sarti; Welington Serra Lazarini; Leonardo Ferreira Fontenelle; Ana Paula Santana Coelho Almeida

    doi:10.1101/2020.07.05.20146811 Date: 2020-07-07 Source: medRxiv

    The world is experiencing one of the greatest public health emergencies in history with the global spread of COVID-19 MESHD. Health systems, including Primary Health Care (PHC) services, are pillars of pandemic coping strategies, and there are important gaps in the literature on the best ways to organize PHC in health crisis scenarios such as the one currently experienced. Given the urgency of responses, we performed a rapid systematic literature review on MEDLINE (via PubMed), EMBASE and LILACS (via VHL HGNC VHL MESHD), in order to analyze empirical studies on the effectiveness of PHC organization strategies in the context of epidemics to improve access and reduce morbidity and mortality. We selected seven articles, which studied the responses to different epidemics in different parts of the world. In terms of access, the studies suggest positive results with the adoption of adjustments of work processes of the teams and the structure of the services, combined with diversification of actions (including call center), adequate provision of inputs and personal protective equipment, adequate action plans and communication strategies, and effective integration with public health services and other levels of care. No study analyzed population morbidity and mortality. The included studies suggest also that community-oriented PHC is more effective in crisis scenarios, indicating the necessity of strengthening of the Family Health Strategy in the Brazilian context.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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