Corpus overview


MeSH Disease

Human Phenotype


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    Prognostic Value of Serum SERO Creatinine in Severe Covid-19 Patients in Wuhan, China: A Retrospective Cohort Study

    Authors: Wei-yun Zhang; De-yu Xu; Chang-guo Wang; Ying-ying Liu; Jian-an Huang; Jun-hong Jiang; Daxiong Zeng

    doi:10.21203/ Date: 2020-06-05 Source: ResearchSquare

    Objectives: Although the respiratory and immune systems are the major targets of SARS-CoV-2, increasing evidence revealed that kidney injury was not rare in coronavirus disease MESHD 2019 (COVID-19). However, the incidences of kidney abnormalities HP were significantly different, from 0.5 to 75.4% in several reports. The association of kidney injury with prognosis remain controversial.Methods:In this retrospective single center cohort study, laboratory confirmedCOVID-19inpatients with severe type were enrolled. Demographic, clinicaland laboratory data were collected. Association ofserum creatinine (SCr)with 28-days mortality in severe COVID-19 patients was analyzed.Results:18.79% (48/304) patients died during the first 28-days of hospitalization.Non-survivors had a significantly higher SCr levels than survivors (109.27μmol/L vs. 69.99μmol/L, P <0.001). The 28-days mortality in high SCr group (>76μmol/L) was significantly higher than that in low SCr group (31.7% vs. 7.5%, P <0.001). Multivariate logistic regression revealed that the independent risk factors of 28-days outcome included age TRANS(OR: 2.95, 95%CI: 1.08-8.05), WBC (OR: 6.09, 95%CI: 2.27-6.39), lymphopenia MESHD lymphopenia HP (OR: 3.49, 95%CI: 1.55-7.92), IL-6 (OR: 4.44, 95%CI: 1.64-11.99) and SCr (OR: 2.69, 95%CI: 1.18-6.11). Kaplan-Meier analysis demonstrated the survival disadvantage in patients with high SCr levels (>76μmol/L). ROC curve showed the SCr cut-off value for predicting 28-days death MESHD was 77.5 μmol/L, with the sensitivity SERO of 68.8% and speciality of 74.1%.Conclusion: SCr was associated with poor prognosis and might be an independent risk factor for in-hospital death MESHD. The cut-off value of SCr for prognosis prediction was 77.5 μmol/L, with the sensitivity SERO of 68.8% and speciality of 74.1%.

    Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection MESHD

    Authors: Wei Lin; Longfei Hu; Yan Zhang; Jushua D. Ooi; Ting Meng; Peng Jin; Xiang Ding; Longkai Peng; Lei Song; Zhou Xiao; Xiang Ao; Xiangcheng Xiao; Qiaoling Zhou; Ping Xiao; Jue Fan; Yong Zhong

    doi:10.1101/2020.02.08.939892 Date: 2020-02-18 Source: bioRxiv

    Since December 2019, a novel coronavirus named 2019 coronavirus (2019-nCoV) has emerged in Wuhan of China and spread to several countries worldwide within just one month. Apart from fever MESHD fever HP and respiratory complications, acute kidney injury MESHD acute kidney injury HP has been observed in some patients with 2019-nCoV. In a short period of time, angiotensin converting enzyme II (ACE2), have been proposed to serve as the receptor for the entry of 2019-nCoV, which is the same for severe acute respiratory syndrome MESHD coronavirus (SARS). To investigate the possible cause of kidney damage in 2019-nCoV patients, we used both published kidney and bladder cell atlas data and an independent unpublished kidney single cell RNA-Seq data generated in-house to evaluate ACE2 gene expressions in all cell types in healthy kidneys and bladders. Our results showed the enriched expression of all subtypes of proximal tubule cells of kidney and low but detectable levels of expression in bladder epithelial cells. These results indicated the urinary system is a potential route for 2019-nCoV infection MESHD, along with the respiratory system and digestion system. Our findings suggested the kidney abnormalities HP of SARS and 2019-nCoV patients may be due to proximal tubule cells damage and subsequent systematic inflammatory response induced kidney injury. Beyond that, laboratory tests of viruses and related indicators in urine may be needed in some special patients of 2019-nCoV.

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MeSH Disease
Human Phenotype

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