Corpus overview


MeSH Disease

Human Phenotype


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    Eurofins Covid-19 Sentinel TM Wastewater Test Provide Early Warning of a potential COVID-19 outbreak

    Authors: Alissa Udi Jorgensen; Jesper Gamst; Line Visby Hansen; Ida Ingeborg Hogh Knudsen; Soren Krohn Skovgaard Jensen

    doi:10.1101/2020.07.10.20150573 Date: 2020-07-11 Source: medRxiv

    The Eurofins Covid-19 SentinelTM program was developed to monitor the evolution of the pandemic and for early detection of outbreaks. The study objective was to develop a wastewater testing method to analyze SARS-CoV-2 as an indicator of community infection MESHD rate resurgence of COVID-19 or in well-defined sites such as production facilities or nursing homes. Eurofins performed >700 tests on 78 unique samples from 18 sites in Denmark, France and Belgium. Ten variant test protocols were trialed. Protocol variations trialed included centrifugation, precipitation of the SARS-CoV-2 RNA, agitation HP prior to precipitation, cooling, and pasteurization of the samples. A method was succesfully developed and reliability was supported by stability, reproducibility, and dilution & linearity studies. Results obtained showed a direct link to number of RNA copies in the sample using a calibration curve with synthetic SARS-CoV-2. Analysis was performed on both the liquid phase and solid phase of wastewater samples, with virus RNA detected in both phases but more frequently in the liquid phase. The virus was present in a sample from a Danish community wastewater treatment plant collected on February 24, 3 days before the first COVID-19 case was officially reported in the country. The greatest concentration of virus detected corresponded to when the COVID-19 crisis was at its peak in Denmark. Based on studies carried out in a Danish hospital, the wastewater testing method is expected to be able to detect a community COVID-19 prevalence SERO rate as low as a 0,02%-0,1% (i.e. between 2 virus shedders per 10000 and 1 virus shedder per 1000). The wastewater testing method was used to monitor a Danish Community after a COVID-19 outbreak and it was shown that the method can be used as a semi-quantitative method to monitor the development of an outbreak.

    Drug-Drug interactions between COVID-19 treatments and antipsychotics drugs: integrated evidence from 4 databases and a systematic review

    Authors: Beatriz Oda Plasencia-Garcia; Gonzalo Rodriguez-Menendez; Maria Isabel Rico-Rangel; Ana Rubio-Garcia; Jaime Torello-Iserte; Benedicto Crespo-Facorro

    doi:10.1101/2020.06.04.20122416 Date: 2020-06-08 Source: medRxiv

    Relevance: Management of symptoms like anxiety HP, delirium MESHD delirium HP and agitation HP cannot be neglected in COVID-19 patients. Antipsychotics are usually used for the pharmacological management of delirium MESHD delirium HP, and confusion MESHD confusion HP and behavioral disturbances. The selection of concomitant COVID-19 medications and antipsychotics should be evidence-based and closely monitored Objective: To systematically review evidence-based available on drug-drug interactions between COVID-19 treatments and antipsychotics. Evidence Review: Three databases were consulted: (a) Lexicomp Drug Interactions, (b) Micromedex Solutions Drugs Interactions, (c) Liverpool Drug Interaction Group for COVID-19 therapies. To acquire more information on QT prolongation and TdP, the CredibleMeds QTDrugs List was searched. Based on the information collected, the authors made a recommendation agreed to by consensus. In addition, a systematic review was conducted to find the clinical outcomes of drug-drug interactions between COVID-19 treatments and antipsychotics Results: The main interaction between COVID-19 drugs and antipsychotics are the risk of QT prolongation and TdP, and CYP interactions. Remdesivir, favipiravir, baricinitib, and anakinra can be used concomitantly with antipsychotics with no risk of drug-drug interaction (except for hematological risk with clozapine and baricinitib). Tocilizumab is rather safe to use in combination with antipsychotics, although it can restore the activity of CYP3A4 and therefore its substrate metabolism may increase. The most demanding COVID-19 treatments for co-administration with antipsychotics are chloroquine, hydroxychloroquine, azithromycin (all prolong QT interval HP) and lopinavir / ritonavir (CYP interaction and risk of QT prolongation). Conclusions: We urge to development of evidence-based guidelines that can help clinicians decide the safest treatment combination and monitoring necessary for each particular patient. The selection of concomitant COVID-19 medications and antipsychotics should be evidence-based and closely monitored.

    Understanding the impact of the COVID-19 pandemic on well-being and virtual care for people living with dementia MESHD dementia HP and care partners living in the community

    Authors: Pamela Roach; Angela Zwiers; Emily Cox; Karyn Fischer; Anna Charlton; Colin B Josephson; Scott B Patten; Dallas Seitz; Zahinoor Ismail; Eric E Smith; - Prompt Collaborators

    doi:10.1101/2020.06.04.20122192 Date: 2020-06-05 Source: medRxiv

    The COVID-19 pandemic has necessitated public health measures that have impacted the provision of care for people living with dementia MESHD dementia HP and their families. Additionally, the isolation that results from social distancing may be harming well-being for families, as formal and informal supports become less accessible. For those with living with dementia MESHD dementia HP and experiencing agitation HP, social distancing may be even harder to maintain, or social distancing could potentially aggravate dementia MESHD dementia HP-related neuropsychiatric symptoms. To understand the lived experience of social and physical distancing during the COVID-19 pandemic in Canada we remotely interviewed 21 participants who normally attend a dementia MESHD dementia HP specialty clinic in Calgary, Alberta, during a period where essential businesses were closed and healthcare had abruptly transitioned to telemedicine. The impacts of the public health measures in response to the pandemic emerged in three main categories of experience: 1) personal; 2) health services; and 3) health status (of both person living with dementia MESHD dementia HP and care partner). This in-depth understanding of the needs and experiences of the pandemic for people living with dementia MESHD dementia HP suggests that innovative means are urgently needed to facilitate provision of remote medicine and also social interaction HP social interaction TRANS and integration.

    Multifocal transient cortical brain lesions: a consistent MRI finding in neuro-COVID-19 patients

    Authors: Nicoletta Anzalone; Antonella Castellano; Roberta Scotti; Anna Mara Scandroglio; Massimo Filippi; Fabio Ciceri; Moreno Tresoldi; Andrea Falini

    doi:10.1101/2020.05.19.20103168 Date: 2020-05-22 Source: medRxiv

    We report four cases of subacute encephalopathy HP occurring in patients with SARS-CoV-2 infection MESHD. All patients have been intubated in the first week from onset of ARDS and presented neurological signs of agitation HP and spatial disorientation after weaning from mechanical ventilation. The MRI picture and the clinical features are described. MRI lesions characteristics are unusual but demonstrate a highly consistent pattern through all the four patients with similar neurological symptoms. They do not fulfill any typical criteria for a definite neuroradiological entity. Their predominantly parieto-occipital distribution recalls SERO posterior reversible encephalopathy HP syndrome MESHD (PRES), although the prevalent cortical involvement and diffusion MRI pattern are not typical of PRES. We speculate that this pattern may be related to a possible transient dysregulation of vasomotor reactivity.

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MeSH Disease
Human Phenotype

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