Corpus overview


MeSH Disease

Human Phenotype


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    Prevalence SERO and Associated Factors of Emotional and Behavioural Difficulties during COVID-19 Pandemic in Children TRANS with Neurodevelopmental Disorders

    Authors: Jacqueline Nonweiler; Fiona Rattray; Jennifer Baulcomb; Francesca Happe; Michael Absoud

    id:10.20944/preprints202007.0636.v1 Date: 2020-07-26 Source:

    Children TRANS and young people (CYP) with neurodevelopmental disorders (NDDs) may be particularly vulnerable to adverse mental health effects due to the COVID-19 pandemic. We conducted a cross-sectional U.K parent TRANS-reported study from 2nd April-2nd June 2020, using the Strengths & Difficulties Questionnaire. CYP with NDDs (n=371) compared to neurotypical controls, had a higher prevalence SERO of emotional symptoms (42% vs 15%), conduct problems (28% vs 9%), and lower prosocial behaviours (54% vs 22%). Those with attention-deficit/hyperactivity disorder HP showed inflated conduct, and those with autism HP spectrum disorder exhibited decreased prosocial behaviours. Females TRANS with ASD had higher emotional symptoms compared to males TRANS.

    The psychological impact of COVID-19 among a sample of Italian individuals with High Functioning Autism HP Spectrum Disorder

    Authors: Veronica Nisticò; Orsola Gambini; Raffaella Faggioli; Benedetta Demartini

    doi:10.21203/ Date: 2020-07-21 Source: ResearchSquare

    Aim of this study was to assess the prevalence SERO of stress, anxiety HP, depression and symptoms related to post-traumatic stress disorder (PTSD) across a sample of 45 adult TRANS subjects with High Functioning Autism HP Spectrum Disorder (HF-ASD) during the first two months of COVID-19 pandemic in Italy, with respect to a sample of 45 healthy controls (HC). We also explored some specific aspects of their psychological well-being through an ad-hoc questionnaire. Our results showed subjects with HF-ASD to have higher rates of depression, anxiety HP, stress and PTSD related symptoms than HC during the first two months of COVID-19 pandemic. However, subjects with HF-ASD, with respect to HC, reported to feel subjectively more comfortable and less tired during the lockdown than before.

    The Experience of Parents TRANS of Children TRANS with Autism HP Spectrum Disorder During the COVID-19 Pandemic: A Qualitative Analysis

    Authors: China Parenteau; Stephen Bent; Bushra Hossain; Yingtong Chen; Felicia Widjaja; Michael Breard; Robert Hendren

    doi:10.21203/ Date: 2020-07-20 Source: ResearchSquare

    Families with children TRANS with autism HP spectrum disorder (ASD) face a unique set of challenges with the rise of the COVID-19 pandemic and shelter-in-place related to a diverse set of issues, including explaining COVID-19 and safety precautions in a comprehensible way, building structure in home for e-learning to take place, and guiding children TRANS back into social situations and the community. We sought to obtain direct feedback through semi-structured interviews from fifteen parents TRANS of children TRANS and adolescents from a non-public school for children TRANS with level 2 and 3 ASD to both develop an initial guide for families, teachers and clinicians caring for children TRANS with ASD and to create awareness in the community about the challenges presented by COVID-19 and shelter-in-place.

    Clinical and molecular characterization of COVID-19 hospitalized patients

    Authors: Elisa Benetti; Annarita Giliberti; Arianna Emiliozzi; Floriana Velentino; Laura Bergantini; Chiara Fallerini; Federico Anedda; Sara Amitrano; Edoardo Conticini; Rossella Tita; Miriana DAlessandro; Francesca Fava; Simona Marcantonio; Margherita Baldassarri; Mirella Bruttini; Maria Antonietta Mazzei; Francesca Montagnani; Marco Mandala; Elena Bargagli; Simone Furini; - COVID-19 MULTICENTER STUDY; Alessandra Renieri; Francesca Mari

    doi:10.1101/2020.05.22.20108845 Date: 2020-05-25 Source: medRxiv

    Clinical and molecular characterization by Whole Exome Sequencing (WES) is reported in 35 COVID-19 patients attending the University Hospital in Siena, Italy, from April 7 to May 7, 2020. Eighty percent of patients required respiratory assistance, half of them being on mechanical ventilation. Fiftyone percent had hepatic involvement and hyposmia HP was ascertained in 3 patients. Searching for common genes by collapsing methods against 150 WES of controls of the Italian population failed to give straightforward statistically significant results with the exception of two genes. This result is not unexpected since we are facing the most challenging common disorder triggered by environmental factors with a strong underlying heritability (50%). The lesson learned from Autism HP-Spectrum-Disorders prompted us to re-analyse the cohort treating each patient as an independent case, following a Mendelian-like model. We identified for each patient an average of 2.5 pathogenic mutations involved in virus infection MESHD susceptibility and pinpointing to one or more rare disorder(s). To our knowledge, this is the first report on WES and COVID-19. Our results suggest a combined model for COVID-19 susceptibility with a number of common susceptibility genes which represent the favorite background in which additional host private mutations may determine disease progression MESHD.

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MeSH Disease
Human Phenotype

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