Background: The coronavirus disease MESHD 2019 (Covid-19) spreads rapidly around the world. Objective: To evaluate the association between comorbidities and the risk of death MESHD in patients with COVID-19, and to further explore potential sex-specific differences. Methods: We analyzed the data from 18,465 laboratory- confirmed cases TRANS that completed an epidemiological investigation in Hubei Province as of February 27, 2020. Information on death MESHD was obtained from the Infectious Disease MESHD Information System. The Cox proportional hazards model was used to estimate the association between comorbidities and the risk of death MESHD in patients with COVID-19. Results: The median age TRANS for COVID-19 patients was 50.5 years. 8828(47.81%) patients were females TRANS. Severe cases accounted for 20.11% of the study population. As of March 7, 2020, a total of 919 cases deceased from COVID-19 for a fatality rate of 4.98%. Hypertension MESHD Hypertension HP (13.87%), diabetes (5.53%), and cardiovascular and cerebrovascular diseases MESHD CBVDs (4.45%) were the most prevalent comorbidities, and 27.37% of patients with COVID-19 reported having at least one comorbidity. After adjustment for age TRANS, gender TRANS, address, and clinical severity, patients with hypertension MESHD hypertension HP (HR 1.55, 95%CI 1.35-1.78), diabetes (HR 1.35, 95%CI 1.13-1.62), CBVDs (HR 1.70, 95%CI 1.43-2.02), chronic kidney diseases HP kidney diseases MESHD (HR 2.09, 95%CI 1.47-2.98), and at least two comorbidities (HR 1.84, 95%CI 1.55-2.18) had significant increased risks of death MESHD. And the association between diabetes and the risk of death MESHD from COVID-19 was prominent in women (HR 1.69, 95%CI 1.27-2.25) than in men (HR 1.16, 95%CI 0.91-1.46) (P for interaction = 0.036). Conclusion: Among laboratory- confirmed cases TRANS of COVID-19 in Hubei province, China, patients with hypertension MESHD hypertension HP, diabetes, CBVDs, chronic kidney diseases HP kidney diseases MESHD were significantly associated with increased risk of death MESHD. The association between diabetes and the risk of death MESHD tended to be stronger in women than in men. Clinicians should increase their awareness of the increased risk of death MESHD in COVID-19 patients with comorbidities.