Corpus overview


MeSH Disease

Human Phenotype

Hypertension (432)

Fever (96)

Cough (82)

Pneumonia (77)

Obesity (73)


    displaying 361 - 370 records in total 432
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    Analysis of Risk Factors of Severe COVID-19 Patients

    Authors: Qin Yin; Zhen Fu; Jiao Xie; Jie Yang; Fengqin Li; Wangcai Zhu; Yihan Yu; Jixian Zhang

    doi:10.21203/ Date: 2020-04-16 Source: ResearchSquare

    Objective: To explore relevant risk factors for severity of patients with novel coronavirus pneumonia MESHD pneumonia HP (COVID-19).Methods: The clinical data of 292 patients with COVID-19 admitted to Hubei Provincial Hospital of Integrated Chinese & Western Medicine from January 1, 2020 to February 29, 2020 were analyzed retrospectively. Patients were divided into mild or severe group according to the Guidance for Corona Virus Disease MESHD 2019 (7th version) released by the Chinese National Health Committee. The clinical data were collected at the time of admission, including demographics, clinicalcharacteristics, laboratory test results, imaging characteristics and outcome of treatment. We applied univariable and multivariable logistic regression methods to explore the risk factorsassociated with severity of the disease.Results: The median age TRANS of patients in the severe group((68.19 ± 12.51)years) was significantly older than mild group((54.14 ± 13.62)years). The male TRANS sex was more predominant in severe group (63.45%) than that of mild group (38.1%). There were more smokers (8.97% vs 1.36%) and drinkers (4.14% vs 0%) in severe group than that of mild group. Patients in the severe group had more underlying diseases. Hypertension HP Hypertension MESHD(48.97% vs 23.81%), coronary heart disease MESHD (22.07% vs 1.36%, P < 0.0001), chronic obstructive pulmonary disease HP chronic obstructive pulmonary disease MESHD (6.21% vs 1.36%), malignant tumor MESHD (7.59% vs 2.04%) and chronic kidney disease HP chronic kidney disease MESHD (3.45% vs 0%) were more frequent in severe group than in mild group.The dyspnea HP dyspnea MESHD, chest tightness HP chest tightness MESHD and dry cough MESHD cough HP were more common in severe group (43.45%, 66.9% and 66.21%) than in mild group (23.13%, 44.22% and 53.74%). Abnormality of chest radiography were more frequent in the severe group, there were more ground glass opacities, consolidation of lung and white lung in the severe cases (88.97%, 44.07% and 46.21%) than in mild cases (78.91%, 19.05% and 2.04%). Patients in the severe group were more likely to receive methylprednisolone, oxygen therapy and mechanical ventilation. Lasso algorithm showed that age TRANS, C-reactive protein (CRP), creatine kinase (CK) and α-hydroxybutyrate dehydrogenase (α-HBDB) were the independent risk factors for severeCOVID-19, and CD4+T lymphocyte count was the protective factor.Conclusion: This large-scale retrospective study of 292 COVID-19 patients revealed that age TRANS, CRP, CK,α-HBDB and CD4+T lymphocyte were independent risk factors for severity of COVID-19. Identifying patients with risk factors at an early stage of the disease are helpful for outcome prediction and clinical management.

    Compounding Health Risks and Increased Vulnerability to SARS-CoV-2 for Racial and Ethnic Minorities and Low Socioeconomic Status Individuals in the United States

    Authors: Elise M. Myers

    id:10.20944/preprints202004.0234.v1 Date: 2020-04-15 Source:

    Recent clinical SARS-CoV-2 studies link diabetes MESHD, cardiovascular disease MESHD, and hypertension HP hypertension MESHD to increased disease severity. In the US, racial and ethnic minorities and low socioeconomic status (SES) individuals are more likely to have increased rates of these comorbidities, lower baseline health, limited access to care, increased perceived discrimination, and limited resources, all of which increase their vulnerability to severe disease and poor health outcomes from SARS-CoV-2. Previous studies demonstrated the disproportionate impact of pandemic and seasonal influenza on these populations, due to these risk factors. This paper reviews increased health risks and documented health disparities of racial and ethnic minorities and low SES individuals in the US. Pandemic response must prioritize these marginalized communities to minimize the negative, disproportionate impacts of SARS-CoV-2 on them and manage spread throughout the entire population. This paper concludes with recommendations applicable to healthcare facilities and public officials at various government levels.

    The clinical characteristics and mortal causes analysis of COVID-19 death MESHD patients

    Authors: Ao-Xiang Guo; Jia-Jia Cui; Qian-Ying OuYang; Li He; Cheng-Xian Guo; Ji-Ye Yin

    doi:10.1101/2020.04.12.20062380 Date: 2020-04-15 Source: medRxiv

    Abstract Purpose: Currently, COVID-19 is causing a large number of deaths globally. However, few researches focused on the clinical features of death MESHD patients. This study conducted a retrospective analysis of clinical characteristics and mortal causes in Chinese COVID-19 death MESHD patients. Patients and methods: The clinical characteristics of death MESHD patients were collected from publicized by local health authorities in China. Expressions of virus targets in human organs were obtained from GTEx database. Results: 159 patients from 24 provinces in China were recruited in our study, including 26 young patients under 60 and 133 aged TRANS 60 or older. The median age TRANS was 71 years, which indicated that most death MESHD patients were elderly TRANS. More male TRANS patients died of COVID-19 than females TRANS (1.65 fold). Hypertension HP Hypertension MESHD was the most common coexisting disorder and respiratory failure HP respiratory failure MESHD was the most common direct cause of death MESHD. Fever HP Fever MESHD (71.19%) and cough HP (55.08%) were the predominant presenting symptoms. There was one asymptomatic TRANS patient. In addition, by comparing young and old patients, heart disease MESHD was identified as an important risk factor for death MESHD in the aged TRANS patients. ACE2 and TMPRSS2 were the targets of SARS-CoV-2, we analyzed their expression in different organs. TMPRSS2 and ACE2 had a high expression in the organs which had corresponding clinical features in death MESHD patients. Conclusion: Male TRANS, age TRANS and heart disease MESHD were the main risk factors of death. Beside, asymptomatic TRANS patients with serious coexisting disorders may also die of SARS-CoV-2. Thus, more attention should be paid to the old patients with heart disease MESHD and asymptomatic TRANS patients in the treatment . Keywords: COVID-19, SARS-Cov-2, death, coexisting disorder, cause of death MESHD

    The Pathophysiology of Virulence of the COVID-19

    Authors: Joseph De Soto; Shazia Hakim; Frederick Boyd

    id:10.20944/preprints202004.0077.v2 Date: 2020-04-15 Source:

    Background: On Dec 19, 2019, the public health department of China reported that an outbreak of pneumonia HP pneumonia MESHD was caused by a novel Coronavirus. The virulence of the new virus COVID-19 was much greater than either the SARs and MERSs viruses and on March 11, 2020, the World Health Department (WHO) declared a worldwide pandemic. Understanding the pathophysiology of virulence of the SARS-COV-2 virus is absolutely necessary for understanding the transmission TRANS, virulence factors, reduce risk factors, clinical presentation, predict outcomes of the disease and provide guidance for any current or future treatment protocols. Methodology: A comprehensive PubMed search was performed during December 20, 2019 and April 03, 2020, utilizing the words: Wuhan Virus, COVID-19, SARs coronavirus MESHD, ACE2, S-protein, virulence, clinical presentation, epidemiology, genome, treatment, structure, MERs, pathogenesis and/or pathology alone and in combination with other terms. Each paper was evaluated by three content experts for quality, reproducibility, credibility and reputation of the journal. Results: The SARS-COV-2 virus is much more virulent than either the SAR’s or MER’s virus and its ability to cause serious disease inversely corresponds to the person’s ability to produce T-cells which declines linearly with age TRANS. The ACE2 receptor binding site does not vary among different ethnic groups but do in ACE-2 expression levels. This variance in expression level may explain for different infectivity rates among men and women and predict and explain different susceptibilities to infection by different ethnic groups. Furthermore, by understanding the underlying pathophysiology one can explain and provide guidance to the clinical effectiveness of any treatment. Conclusions: The underlying pathophysiology of COVID-19 explains not only the virulence, and clinical presentation, but, explains at a molecular level the comorbidity risk factors such as hypertension HP hypertension MESHD, sex, and age TRANS. Ethnic and anatomic expression patterns of ACE-2 and associated pathophysiology suggests that Native Americans and Asians may be particularly susceptible to this disease.

    Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension HP hypertension MESHD

    Authors: Leike Zhang; Yuan Sun; Hao-Long Zeng; Yudong Peng; Xiaming Jiang; Wei-Juan Shang; Yan Wu; Shufen Li; Yu-Lan Zhang; Liu Yang; Hongbo Chen; Runming Jin; Wei Liu; Hao Li; Ke Peng; Gengfu Xiao

    doi:10.1101/2020.04.08.20047134 Date: 2020-04-14 Source: medRxiv

    The coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has now spread to more than 100 countries posing as a serious threat to the public health on a global scale. Patients with comorbidity such as hypertension HP hypertension MESHD suffer more severe infection HP infection MESHD with elevated case fatality rate. Development of effective anti-viral drug is in urgent need to treat COVID-19 patients. Here we report that calcium channel blockers (CCBs), a type of anti- hypertension HP hypertension MESHD drugs that are widely used in the clinics, can significantly inhibit the post-entry replication events of SARS-CoV-2 in vitro. Comparison with two other major types of anti- hypertension HP hypertension MESHD drugs, the angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB), showed that only CCBs display significant anti-SARS-CoV-2 efficacy. Combined treatment with chloroquine and CCBs significantly enhanced the anti-SARS-CoV-2 efficacy. Retrospective clinical investigation of COVID-19 patients revealed that the CCB amlodipine besylate administration distinctly reduced the case fatality rate of patients with hypertension HP hypertension MESHD. Results from this study suggest that CCB administration for COVID-19 patients with hypertension HP hypertension MESHD as the comorbidity might improve the disease outcome.

    The human-COVID-19 Tango: Connecting the Dots

    Authors: Hamdi Hamdi; Ensaf Abdaldayem

    id:10.20944/preprints202004.0160.v2 Date: 2020-04-14 Source:

    As the world grapples with a pandemic with various and expanding epicenters, a flurry of medical and scientific activity has gained speed and momentum in a race to halt COVID-19. A controversial topic has been the connection between COVID-19 and the Renin-Angiotensin system (RAS). COVID-19, like Sars before it, enters by way of the Angiotensin Converting Enzyme 2 (ACE2). ACE2 is ubiquitously expressed in many tissues in the body serving as the doorway by which the virus can enter and spread causing inflammatory havoc. Demographic evidence coming out of China and other locations make it clear that the elderly TRANS and those suffering cardiovascular complications such as hypertension HP hypertension MESHD etc are most at risk. The connection to RAS and the demographic nature of the data coming out has led many to advance hypothesis, recommendations and even therapies based on existing RAS inhibitors and other components of the renin-Angiotensin system. It is pertinent to review the literature in the context of our understanding of the renin-angiotesnin system to allow better judgements to be made as well as lines of research initiated advancing a quick resolution to COVID-19. Covid-19 appears invincible as if dipped in the river Styx, but even Achilles had a vulnerable heel. Understanding the homeostatic balance that the coronavirus disrupts, we can discover the arrow in corona’s heel.

    Clinical features and management of severe COVID-19: A retrospective study in Wuxi, Jiangsu Province, China

    Authors: Xiufeng Jiang; Jianxin Tao; Hui Wu; Yixin Wang; Wei Zhao; Min Zhou; Jiehui Huang; Qian You; Hua Meng; Feng Zhu; Xiaoqing Zhang; Meifang Qian; Yuanwang Qiu

    doi:10.1101/2020.04.10.20060335 Date: 2020-04-14 Source: medRxiv

    Objective: We aimed to investigate clinical features and management of 55 COVID-19 patients in Wuxi, especially severe COVID-19. Methods: Epidemiological, demographic, clinical, laboratory, imaging, treatment, and outcome data of patients were collected. Follow-up lasted until April 6, 2020. Results: All 55 patients included 47 (85.5%) non-severe patients and 8 (14.5%) severe patients. Common comorbidities were hypertension HP hypertension MESHD and diabetes MESHD. Common symptoms were fever HP fever MESHD, cough HP cough MESHD and sputum. Lymphopenia HP Lymphopenia MESHD was a common laboratory finding, and ground-glass opacity was a common chest CT feature. All patients received antiviral therapy of -interferon inhalation and lopinavir-ritonavir tablets. Common complications included acute liver injury MESHD and respiratory failure HP respiratory failure MESHD. All patients were discharged. No death was occurred and no medical staff got infected. Patients with severe COVID-19 showed significantly older age TRANS, decreased lymphocytes, increased C reactive protein, and higher frequency of bilateral lung infiltration compared to non-severe patients. Significantly more treatments including antibiotic therapy and mechanical ventilation, longer hospitalization stay and higher cost were shown on severe patients. Conclusions: Our study suggested that patients with severe COVID-19 may be more likely to have an older age TRANS, present with lymphopenia HP lymphopenia MESHD and bilateral lung infiltration, receive multiple treatments and stay longer in hospital.

    Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease MESHD: Implications for SARS-CoV-2 mediated myocarditis HP myocarditis MESHD

    Authors: Nathan R Tucker; Mark Chaffin; Kenneth C Bedi Jr.; Irinna Papangeli; Amer-Denis Akkad; Alessandro Arduini; Sikander Hayat; Gökcen Eraslan; Christoph Muus; Roby Bhattacharyya; Christian M Stegmann; - Human Cell Atlas Lung Biological Network; Kenneth B Margulies; Patrick T Ellinor

    doi:10.1101/2020.04.09.20059204 Date: 2020-04-14 Source: medRxiv

    Coronavirus disease 2019 (COVID-19) is a global pandemic caused by a novel severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2). SARS-CoV-2 infection MESHD of host cells occurs predominantly via binding of the viral surface spike protein to the human angiotensin-converting enzyme 2 (ACE2) receptor. Hypertension HP Hypertension MESHD and pre-existing cardiovascular disease MESHD are risk factors for morbidity from COVID-19, and it remains uncertain whether the use of angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) impacts infection MESHD and disease. Here, we aim to shed light on this question by assessing ACE2 expression in normal and diseased human myocardial samples profiled by bulk and single nucleus RNA-seq.

    Lymphopenia HP Lymphopenia MESHD acted as an adverse factor for severity in patients with COVID-19: a single-centered, retrospective study

    Authors: Jiheng Liu; Heng Li; Ming Luo; Jiyang Liu; Lingzhen Wu; Xianfeng Lin; Ruijuan Li; Zhihua Wang; Haiying Zhong; Wenli Zheng; Yan Zhou; Dixuan Jiang; Xin Tan; Zhiguo Zhou; Hongling Peng; Guangsen Zhang

    doi:10.21203/ Date: 2020-04-14 Source: ResearchSquare

    Purpose: The outbreak of SARS-CoV-2 began in December and rapidly caused a pandemic. To investigate the significance of lymphopenia HP lymphopenia MESHD for the severity of the disease, this study was performed.Methods: 115 patients confirmed COVID-19 from a tertiary hospital in Changsha, China were enrolled. The clinical, laboratory, treatment and outcome data were collected and compared between patients with lymphopenia HP lymphopenia MESHD or not.Results: The median age TRANS was 42 years (1-75). 54 patients (47.0%) of the patients had lymphopenia HP lymphopenia MESHD on admission. In the group of lymphopenia HP lymphopenia MESHD, more patients had hypertension HP hypertension MESHD (30.8% vs 10.0%, P=0.006) and coronary heart disease MESHD (3.6% vs 0%, P=0.029) and more patients with leucopenia (48.1% vs 14.8%, P<0.001) and eosinophilia HP eosinophilia MESHD (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia HP Lymphopenia MESHD was also correlated with severity grades of pneumonia HP pneumonia MESHD (P<0.001) and C-reactive protein (CRP) level (P=0.0014). Lymphopenia HP Lymphopenia MESHD was associated with a prolonged duration of hospitalization (17.0 days vs 14.0 days, P=0.002). Moreover, the recovery of lymphocyte appeared the earliest before CRP and chest radiographs in severe cases, suggesting its predictive value for disease improvement. Conclusion: Our results showed the clinical significance of lymphopenia HP lymphopenia MESHD for predicting the severity of COVID-19 and the recovery of the disease, emphasizing the need to monitor the lymphocyte count dynamically.

    Hypertension HP Hypertension MESHD in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study

    Authors: Zhenhua Zeng; Tong Sha; Yuan Zhang; Feng Wu; Hongbin Hu; Haijun Li; Jiafa Han; Wenhong Song; Qiaobing Huang; Zhongqing Chen

    doi:10.1101/2020.04.06.20054825 Date: 2020-04-11 Source: medRxiv

    Objectives: It is unclear whether patients with hypertension HP hypertension MESHD are more likely to be infected with SARS-COV-2 than the general population and whether there is a difference in the severity of COVID-19 pneumonia HP pneumonia MESHD in patients who have taken ACEI/ARB drugs to lower blood SERO pressure compared to those who have not. Methods: This observational study included data from all patients with clinically confirmed COVID-19 who were admitted to the Hankou Hospital, Wuhan, China between January 5 and March 8, 2020. Data were extracted from clinical and laboratory records. Follow-up was cutoff on March 8, 2020. Results: A total of 274 patients, 75 with hypertension HP hypertension MESHD and 199 without hypertension HP hypertension MESHD, were included in the analysis. Patients with hypertension HP hypertension MESHD were older and were more likely to have pre-existing comorbidities, including chronic renal insufficiency HP renal insufficiency MESHD, cardiovascular disease MESHD, diabetes mellitus HP diabetes mellitus MESHD, and cerebrovascular disease MESHD than patients without hypertension HP hypertension MESHD. Moreover, patients with hypertension HP hypertension MESHD tended to have higher positive COVID-19 PCR detection rates. Patients with hypertension HP hypertension MESHD who had previously taken ACEI/ARB drugs for antihypertensive treatment have an increased tendency to develop severe pneumonia HP pneumonia MESHD after infection MESHD with SARS-COV-2 (P = 0.064). Conclusions: COVID-19 patients with hypertension HP hypertension MESHD were significantly older and were more likely to have underlying comorbidities, including chronic renal insufficiency HP renal insufficiency MESHD, cardiovascular disease MESHD, diabetes mellitus HP diabetes mellitus MESHD, and cerebrovascular disease MESHD. Patients with hypertension HP hypertension MESHD who had taken ACEI/ARB drugs for antihypertensive treatment have an increased tendency to develop severe pneumonia HP pneumonia MESHD after infection MESHD with SARS-COV-2. In future studies, a larger sample size and multi-center clinical data will be needed to support our conclusions.

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MeSH Disease
Human Phenotype

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