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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    COVID-19 Comorbidity and Metabolic Syndrome MESHD: Is There a Molecular Basis?

    Authors: Madhurima Basu; Chinmay Saha; Kamalika Roy Choudhury; Susmita Dutta; Sujoy Ghosh; Subhankar Chowdhury; Satinath Mukhopadhyay; Nitai P. Bhattacharyya

    id:10.20944/preprints202006.0245.v1 Date: 2020-06-21 Source: preprints.org

    The risk factors associated with COVID-19 related severity, morbidity, and mortality, i.e., obesity MESHD obesity HP (often associated with NAFLD), hyperglycemia MESHD hyperglycemia HP, hypertension MESHD hypertension HP and dyslipidemia all cluster together as metabolic syndrome MESHD (MetS). Instead of studying association of these risk factors with COVID-19, it makes sense studying the association between MetS on one hand and COVID-19 on the other. This study explores a molecular basis underpinning the above association. Severity of COVID-19 patients with MetS could be due to functional alterations of host proteins due to their interactions with viral proteins. We collected data from Enrichr (https://amp.pharm.mssm.edu/Enrichr/), DisGeNET (https://www.disgenet.org/) and others and carried out enrichment analysis using Enrichr. Various biological processes and pathways associated with viral protein interacting partners are known to involve in metabolic diseases MESHD. The molecular pathways underlying insulin resistance MESHD insulin resistance HP, insulin signaling and insulin secretion are not only involved in diabetes but also in CVD and obesity MESHD obesity HP (associated with non-alcoholic fatty liver disease MESHD; NAFLD). Lipid metabolism/lipogenesis, fatty acid oxidation and inflammation MESHD are associated with MetS. Viral interacting host proteins are associated and enriched with terms like hyperglycemia MESHD hyperglycemia HP, coronary artery disease MESHD, hypertensive disease MESHD related to CVD and liver diseases MESHD in DisGeNET. Association of viral interacting proteins with disease MESHD-relevant biological processes, pathways and disease MESHD-related terms suggests that altered host protein function following interaction with viral proteins might contribute to frequent occurrence and/or severity of COVID-19 in subjects with MetS. Such analysis not only provides a molecular basis of comorbidity but also incriminates host proteins in viral replication, growth and identifies possible drug targets for intervention.

    Plasma SERO levels of soluble ACE2 are associated with sex, Metabolic Syndrome MESHD, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19

    Authors: Sergey A Kornilov; Isabelle Lucas; Kathleen Jade; Chengzhen L Dai; Jennifer C Lovejoy; Andrew T Magis

    doi:10.1101/2020.06.10.20127969 Date: 2020-06-12 Source: medRxiv

    We examined the associations between plasma SERO concentrations of soluble ACE2 and biomarkers of Metabolic Syndrome MESHD in a large (N=2,051) sample of individuals who participated in a commercial wellness program and who underwent deep molecular phenotyping. sACE2 levels were significantly higher in men, compared to women, and in individuals with Metabolic Syndrome MESHD, compared to controls. sACE2 levels showed reliable associations with all individuals components of Metabolic Syndrome MESHD, including obesity MESHD obesity HP, hypertension MESHD hypertension HP, insulin resistance MESHD insulin resistance HP, hyperlipidemia MESHD hyperlipidemia HP, and as well as markers of liver damage. This profile of associations was statistically significantly stronger in men, compared to women, and suggests that preexisting cardiometabolic conditions might confer increased severity of symptoms in some COVID-19 patients through increased expression of ACE2 in the liver.

    Higher Body Mass Index is an Important Risk factor in COVID-19 patients: A Systematic Review

    Authors: Vivek Singh Malik; Ravindra Khaiwal; Savita Verma Attri; Sanjay Kumar Bhadada; Meenu Singh

    doi:10.1101/2020.05.11.20098806 Date: 2020-05-18 Source: medRxiv

    Background: Globally, both obesity MESHD obesity HP and underweight are severe health risks for various diseases MESHD. The current study systematically examines the emerging evidence to identify an association between Body Mass Index (BMI) and COVID-19 disease MESHD outcome. Methods: Online literature databases (e.g., Google Scholar, PubMed, MEDLINE, EMBASE, Scopus, Medrixv and BioRixv) were screened following standard search strategy having the appropriate keyword such as Obesity MESHD Obesity HP, Underweight, BMI, Body Mass Index, 2019-nCov, COVID-19, novel coronavirus, coronavirus disease MESHD. Studies published till 20th April 2020 were included without language restriction. These studies include case reports, case series, cohort, and any other which reported BMI, overweight MESHD overweight HP/ obesity MESHD obesity HP or underweight, and its complication with COVID-19 disease MESHD. Findings: Obesity MESHD Obesity HP plays a significant part in the pathogenesis of COVID-19 patients, though the role of BMI in the COVID-19 pandemic must not be ignored. Interpretation: Consequences of inflammation MESHD of adipose tissue has been reported as a leading cause of insulin resistance MESHD insulin resistance HP and hypertension MESHD hypertension HP due to metabolic dysfunction. The results of the current study show that BMI plays a significant role in COVID-19 severity in all ages TRANS, especially the elderly TRANS population. A panel should review COVID-19 patients with higher BMI and other co-morbidities, and they should be given increased vigilance, testing priority, and therapy. Further, the COVID-19 patients whose illness entered 7-10 days, age TRANS >50 yrs, and elevated CRP levels should have additional medical considerations. Recommendation: Population and patients with high BMI have moderate to high risk of medical complications with COVID-19, and hence their health status should be monitored more frequently. Keywords: Age TRANS, BMI, COVID-19, Obesity MESHD Obesity HP.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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